scholarly journals Mechanisms of neocortical development

2009 ◽  
Vol 587 (9) ◽  
pp. 1871-1872 ◽  
Author(s):  
John T. R. Isaac ◽  
Dirk Feldmeyer
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Lipin Loo ◽  
Jeremy M. Simon ◽  
Lei Xing ◽  
Eric S. McCoy ◽  
Jesse K. Niehaus ◽  
...  

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 118
Author(s):  
David de Agustín-Durán ◽  
Isabel Mateos-White ◽  
Jaime Fabra-Beser ◽  
Cristina Gil-Sanz

The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell–cell adhesion molecules (C-CAMs), classical cadherins and nectins, as well as in their effectors, in the control of fundamental processes related with corticogenesis, with special attention in the cooperative actions among the two families of C-CAMs.


2014 ◽  
Vol 71 (16) ◽  
pp. 2975-2995 ◽  
Author(s):  
Olga Barca-Mayo ◽  
Davide De Pietri Tonelli

Neuroscience ◽  
2013 ◽  
Vol 253 ◽  
pp. 256-273 ◽  
Author(s):  
G. Wilkinson ◽  
D. Dennis ◽  
C. Schuurmans

Author(s):  
Mark S. Blumberg ◽  
John H. Freeman ◽  
Scott R. Robinson ◽  
Bryan Kolb ◽  
Celeste Halliwell ◽  
...  

2020 ◽  
Vol 10 (12) ◽  
pp. 909
Author(s):  
Allison M. Bond ◽  
Daniel A. Berg ◽  
Stephanie Lee ◽  
Alan S. Garcia-Epelboim ◽  
Vijay S. Adusumilli ◽  
...  

Neocortical development has been extensively studied and therefore is the basis of our understanding of mammalian brain development. One fundamental principle of neocortical development is that neurogenesis and gliogenesis are temporally segregated processes. However, it is unclear how neurogenesis and gliogenesis are coordinated in non-neocortical regions of the cerebral cortex, such as the hippocampus, also known as the archicortex. Here, we show that the timing of neurogenesis and astrogenesis in the Cornu Ammonis (CA) 1 and CA3 regions of mouse hippocampus mirrors that of the neocortex; neurogenesis occurs embryonically, followed by astrogenesis during early postnatal development. In contrast, we find that neurogenesis in the dentate gyrus begins embryonically but is a protracted process which peaks neonatally and continues at low levels postnatally. As a result, astrogenesis, which occurs during early postnatal development, overlaps with the process of neurogenesis in the dentate gyrus. During all stages, neurogenesis overwhelms astrogenesis in the dentate gyrus. In addition, we find that the timing of peak astrogenesis varies by hippocampal subregion. Together, our results show differential timing and coordination of neurogenesis and astrogenesis in developing mouse hippocampal subregions and suggest that neurogenesis and gliogenesis occur simultaneously during dentate gyrus development, challenging the conventional principle that neurogenesis and gliogenesis are temporally separated processes.


Neuron ◽  
2019 ◽  
Vol 103 (5) ◽  
pp. 785-801.e8 ◽  
Author(s):  
Damon Polioudakis ◽  
Luis de la Torre-Ubieta ◽  
Justin Langerman ◽  
Andrew G. Elkins ◽  
Xu Shi ◽  
...  

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