scholarly journals Sublinear summation of afferent inputs to the nucleus accumbens in the awake rat

2009 ◽  
Vol 587 (8) ◽  
pp. 1695-1704 ◽  
Author(s):  
John A. Wolf ◽  
Leif H. Finkel ◽  
Diego Contreras
Keyword(s):  
Nucleus Accumbens ◽  
Awake Rat ◽  
Afferent Inputs

scholarly journals Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release

2021 ◽  
Vol 13 ◽  
Author(s):  
Dan P. Covey ◽  
Alyssa G. Yocky
Keyword(s):  
Nucleus Accumbens ◽  
Activity Patterns ◽  
Cell Types ◽  
Neural Architecture ◽  
Afferent Projections ◽  
Complex Interactions ◽  
Distinct Cell ◽  
Afferent Inputs ◽  
Control Terminal ◽  
Da Release

The nucleus accumbens (NAc) is located in the ventromedial portion of the striatum and is vital to valence-based predictions and motivated action. The neural architecture of the NAc allows for complex interactions between various cell types that filter incoming and outgoing information. Dopamine (DA) input serves a crucial role in modulating NAc function, but the mechanisms that control terminal DA release and its effect on NAc neurons continues to be elucidated. The endocannabinoid (eCB) system has emerged as an important filter of neural circuitry within the NAc that locally shapes terminal DA release through various cell type- and site-specific actions. Here, we will discuss how eCB signaling modulates terminal DA release by shaping the activity patterns of NAc neurons and their afferent inputs. We then discuss recent technological advancements that are capable of dissecting how distinct cell types, their afferent projections, and local neuromodulators influence valence-based actions.

Medullary inputs to nucleus accumbens neurons

1997 ◽  
Vol 273 (6) ◽  
pp. R2080-R2088 ◽  
Author(s):  
Gilbert J. Kirouac ◽  
John Ciriello
Keyword(s):  
Nucleus Accumbens ◽  
Discharge Rate ◽  
Systemic Arterial Pressure ◽  
Ventrolateral Medulla ◽  
Cell Group ◽  
Unit Recording ◽  
Arterial Baroreceptors ◽  
Afferent Inputs ◽  
Shell Region ◽  
Stimulation Of

Extracellular single-unit recording experiments were done in α-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of stimulation of the nucleus of the solitary tract (NTS) and the ventrolateral medulla (VLM) in the region of the A1 noradrenergic cell group on the activity of neurons in the nucleus accumbens (NA). In addition, the response of NA neurons to activation of the arterial baroreceptors was investigated. Electrical or glutamate (Glu) stimulation of the ipsilateral NTS excited 47 of 99 (48%) and inhibited 10 of 99 (10%) of the units tested in the NA. Similarly, electrical or Glu stimulation of the ipsilateral VLM excited 24 of 97 (24.7%) or inhibited 7 of 97 (7.2%) of the units tested. Approximately 22% (17 of 77) of these units responded to stimulation of both the NTS and VLM. Simultaneous stimulation of both the NTS and VLM potentiated the response of the NA neuron tested. CoCl2 injection into the ipsilateral NTS did not alter the response of NA neurons to stimulation of the VLM. Similarly, CoCl2 injections into the ipsilateral VLM did not alter the response of NA neurons to NTS stimulation. The discharge rate of some of the units (6 of 49) that were activated by both NTS and VLM was also increased during the activation of arterial baroreceptors by the acute rise in systemic arterial pressure to phenylephrine injection. Units that responded to stimulation of the NTS and VLM and to baroreceptor activation were located in the shell region of the NA. These data indicate that afferent inputs from the NTS and VLM converge onto NA neurons and suggest that visceral and cardiovascular afferent inputs may influence the output of neurons in the shell region of the NA.

Circadian rhythms of dopamine, glutamate and GABA in the striatum and nucleus accumbens of the awake rat: modulation by light

2004 ◽  
Vol 36 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Tamara R. Castañeda ◽  
Blanca Marquez Prado ◽  
David Prieto ◽  
Francisco Mora
Keyword(s):  
Nucleus Accumbens ◽  
Circadian Rhythms ◽  
Awake Rat
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