scholarly journals Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase

2009 ◽  
Vol 587 (13) ◽  
pp. 3363-3373 ◽  
Author(s):  
Melissa A. Chambers ◽  
Jennifer S. Moylan ◽  
Jeffrey D. Smith ◽  
Laurie J. Goodyear ◽  
Michael B. Reid
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Map Kinase ◽  
Glucose Uptake ◽  
Reactive Oxygen ◽  
P38 Map Kinase ◽  
Oxygen Species

Effects of eosinophils on nerve cell morphology and development: the role of reactive oxygen species and p38 MAP kinase

2003 ◽  
Vol 285 (4) ◽  
pp. L915-L924 ◽  
Author(s):  
Paul J. Kingham ◽  
W. Graham McLean ◽  
Marie-Therese Walsh ◽  
Allison D. Fryer ◽  
Gerald J. Gleich ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Map Kinase ◽  
Nerve Cell ◽  
Cell Morphology ◽  
Kinase Inhibitor ◽  
Reactive Oxygen ◽  
P38 Map Kinase ◽  
Nerve Cells ◽  
Oxygen Species ◽  
Neurite Retraction

The adhesion of eosinophils to nerve cells and the subsequent release of eosinophil products may contribute to the pathogenesis of conditions such as asthma and inflammatory bowel disease. In this study we have separately examined the consequences of eosinophil adhesion and degranulation for nerve cell morphology and development. Eosinophils induced neurite retraction of cultured guinea pig parasympathetic nerves and differentiated IMR32 cholinergic neuroblastoma cells. Inhibition of eosinophil adhesion to IMR32 cells attenuated this retraction. Eosinophil adhesion to IMR32 cells led to tyrosine phosphorylation of a number of nerve cell proteins, activation of p38 MAP kinase, and generation of neuronal reactive oxygen species (ROS). Inhibition of tyrosine kinases with genistein prevented both the generation of ROS in the nerve cells and neurite retraction. The p38 MAP kinase inhibitor SB-239063 prevented neurite retraction but had no effect on the induction of ROS. Thus eosinophils induced neurite retraction via two distinct pathways: by generation of tyrosine kinase-dependent ROS and by p38 MAP kinase. Eosinophils also prevented neurite outgrowth during differentiation of IMR32 cells. In contrast to their effect on neurite retraction, this effect was mimicked by medium containing products released from eosinophils and by eosinophil major basic protein. These results indicate that eosinophils modify the morphology of nerve cells by distinct mechanisms that involve adhesion and released proteins.

scholarly journals Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161343 ◽  
Author(s):  
Deborah Grimberg-Peters ◽  
Carina Büren ◽  
Joachim Windolf ◽  
Thorsten Wahlers ◽  
Adnana Paunel-Görgülü
Keyword(s):  
Reactive Oxygen Species ◽  
Map Kinase ◽  
Hyperbaric Oxygen ◽  
Reactive Oxygen ◽  
P38 Map Kinase ◽  
Oxygen Species
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