scholarly journals α-Adrenergic signalling activates protein kinase D and causes nuclear efflux of the transcriptional repressor HDAC5 in cultured adult mouse soleus skeletal muscle fibres

2009 ◽  
Vol 587 (5) ◽  
pp. 1101-1115 ◽  
Author(s):  
Yewei Liu ◽  
Minerva Contreras ◽  
Tiansheng Shen ◽  
William R. Randall ◽  
Martin F. Schneider
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Adult Mouse ◽  
Transcriptional Repressor ◽  
Protein Kinase D ◽  
Muscle Fibres ◽  
Skeletal Muscle Fibres

scholarly journals Spontaneous and voltage-activated Ca2+release in adult mouse skeletal muscle fibres expressing the type 3 ryanodine receptor

2008 ◽  
Vol 586 (2) ◽  
pp. 441-457 ◽  
Author(s):  
Claude Legrand ◽  
Emiliana Giacomello ◽  
Christine Berthier ◽  
Bruno Allard ◽  
Vincenzo Sorrentino ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Adult Mouse ◽  
Muscle Fibres ◽  
Mouse Skeletal Muscle ◽  
Skeletal Muscle Fibres ◽  
Type 3

scholarly journals Protein kinase D controls voluntary-running-induced skeletal muscle remodelling

2011 ◽  
Vol 440 (3) ◽  
pp. 327-335 ◽  
Author(s):  
Kornelia Ellwanger ◽  
Christine Kienzle ◽  
Sylke Lutz ◽  
Zheng-Gen Jin ◽  
Maria T. Wiekowski ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Nuclear Export ◽  
Muscle Performance ◽  
Protein Kinase D ◽  
Muscle Fibres ◽  
Voluntary Running ◽  
Conditional Expression ◽  
Muscle Remodelling ◽  
Class Iia Hdacs

Skeletal muscle responds to exercise by activation of signalling pathways that co-ordinate gene expression to sustain muscle performance. MEF2 (myocyte enhancer factor 2)-dependent transcriptional activation of MHC (myosin heavy chain) genes promotes the transformation from fast-twitch into slow-twitch fibres, with MEF2 activity being tightly regulated by interaction with class IIa HDACs (histone deacetylases). PKD (protein kinase D) is known to directly phosphorylate skeletal muscle class IIa HDACs, mediating their nuclear export and thus derepression of MEF2. In the present study, we report the generation of transgenic mice with inducible conditional expression of a dominant-negative PKD1kd (kinase-dead PKD1) protein in skeletal muscle to assess the role of PKD in muscle function. In control mice, long-term voluntary running experiments resulted in a switch from type IIb+IId/x to type IIa plantaris muscle fibres as measured by indirect immunofluorescence of MHCs isoforms. In mice expressing PKD1kd, this fibre type switch was significantly impaired. These mice exhibited altered muscle fibre composition and decreased running performance compared with control mice. Our findings thus indicate that PKD activity is essential for exercise-induced MEF2-dependent skeletal muscle remodelling in vivo.

Interferon-gamma-like immunoreactivity and T-cell marker expression in rat skeletal muscle fibres

1989 ◽  
Vol 504 (2) ◽  
pp. 306-310 ◽  
Author(s):  
Inger Nennesmo ◽  
Tomas Olsson ◽  
Åke Ljungdahl ◽  
Krister Kristensson ◽  
Peter H. Van der Meide
Keyword(s):  
Skeletal Muscle ◽  
T Cell ◽  
Interferon Gamma ◽  
Muscle Fibres ◽  
Cell Marker ◽  
Rat Skeletal Muscle ◽  
Marker Expression ◽  
Skeletal Muscle Fibres
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