scholarly journals Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

2009 ◽  
Vol 587 (1) ◽  
pp. 211-217 ◽  
Author(s):  
Vinod Kumar ◽  
Anna Selby ◽  
Debbie Rankin ◽  
Rekha Patel ◽  
Philip Atherton ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Resistance Exercise ◽  
Dose Response ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Age Related ◽  
Old Men ◽  
Relationship Of

Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnoverThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 34 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Michael J. Rennie
Keyword(s):  
Protein Synthesis ◽  
Protein Metabolism ◽  
Older Persons ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Anabolic Resistance ◽  
Muscle Protein Metabolism ◽  
The Right

In healthy active older persons, there is no derangement of muscle protein metabolism. However, there is a major deficit in the ability of older muscles to regulate their maintenance during feeding and exercise. The dose–response relationship between myofibrillar protein synthesis and the availability of essential amino acids (EAA) is shifted down and to the right, and giving extra amino acids is unable to overcome this. There is no sex difference in basal or fed muscle protein metabolism in the young, but postmenopausal women have a greater anabolic resistance than older men. Anabolic resistance is also shown by the decreased phosphorylation in the PKB–mTOR–eIF4BP1 pathway in response to increased EAA. The muscle synthetic system is refractory to EAA provision, irrespective of the availability of insulin, insulin-like growth factor 1, and growth hormone. However, insulin is a major regulator of muscle protein breakdown, and there is a blunting of the ability of older muscle to decrease proteolysis in response to low concentrations of insulin, such as those observed after a light breakfast. Providing more EAA seems not to be useful, and modern N-balance data confirm that the dietary protein requirements of older persons are not increased. The sigmoidal dose–response relationship between muscle protein synthesis and resistance exercise intensity is shifted downward and to the right in older men. Decreased physical activity itself, even in young subjects, can produce anabolic resistance of muscle protein synthesis, which cannot be overcome by increasing amino acid availability. Exercise may retune the amino acid and (or) insulin sensitivity of muscle in older people.

Age-related Differences In Muscle Protein Synthesis And mTORC1 Signaling Following Resistance Exercise: A 24-hour Time-course

2010 ◽  
Vol 42 ◽  
pp. 63
Author(s):  
Christopher S. Fry ◽  
Micah J. Drummond ◽  
Erin L. Glynn ◽  
Jared M. Dickinson ◽  
David M. Gundermann ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Resistance Exercise ◽  
Time Course ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Age Related ◽  
Mtorc1 Signaling

Underestimation of Dose - Response Relationship with Particular Reference to the Relationship between the Dietary Intake of Mercury and its Concentration in Blood

1988 ◽  
Vol 7 (2) ◽  
pp. 129-132 ◽  
Author(s):  
J.C. Sherlock ◽  
M.J. Quinn
Keyword(s):  
Linear Regression ◽  
Dietary Intake ◽  
Dose Response ◽  
Mercury Concentration ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Blood Mercury ◽  
Relationship Of ◽  
The Relationship ◽  
Blood Mercury Concentration

Wide discrepancies have been observed between controlled and uncontrolled intake studies of the relationship of blood mercury concentration to intake of mercury. The probable reason for the apparent discrepancies is that the within-subject variation of mercury intake in the uncontrolled studies was almost certainly considerably larger than the within-subject variation in blood mercury concentration; in these circumstances, the apparent slope obtained from a linear regression of blood mercury on intake will invariably be much smaller than the true slope. Studies of the exposure or intake of any substance should therefore include a consideration of the likely within-subject variation in the exposure or intake relative to that in the effect.

A model analysis for dose–response relationship of warfarin in Japanese children: An introduction of the SIZE parameter

2016 ◽  
Vol 31 (3) ◽  
pp. 234-241 ◽  
Author(s):  
Saki Nakamura ◽  
Nao Watanabe ◽  
Naoki Yoshimura ◽  
Sayaka Ozawa ◽  
Keiichi Hirono ◽  
...  
Keyword(s):  
Dose Response ◽  
Model Analysis ◽  
Response Relationship ◽  
Size Parameter ◽  
Dose Response Relationship ◽  
Japanese Children ◽  
Relationship Of

The Dose-Response Relationship of Ondansetron in the Prophylaxis of Pediatric Postoperative Emesis

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A1351
Author(s):  
M. F. Watcha ◽  
P. J. Bras ◽  
J. Pennant ◽  
G. Cieslak ◽  
D. Burnette
Keyword(s):  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Relationship Of

scholarly journals The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein

2016 ◽  
Vol 4 (15) ◽  
pp. e12893 ◽  
Author(s):  
Lindsay S. Macnaughton ◽  
Sophie L. Wardle ◽  
Oliver C. Witard ◽  
Chris McGlory ◽  
D. Lee Hamilton ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Resistance Exercise ◽  
Whey Protein ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Whole Body ◽  
Body Resistance
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