scholarly journals GABAergic synapse maturation: evidence of the instructive role of activity-dependent BDNF release

2008 ◽  
Vol 586 (21) ◽  
pp. 5041-5041
Author(s):  
Lucas Pozzo-Miller
Keyword(s):  
Gabaergic Synapse ◽  
Synapse Maturation ◽  
Activity Dependent

scholarly journals Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Bidisha Chattopadhyaya
Keyword(s):  
Neurodevelopmental Disorders ◽  
Critical Period ◽  
Molecular Mechanisms ◽  
Synapse Formation ◽  
Neural Circuits ◽  
Normal Function ◽  
Gabaergic Synapse ◽  
Synapse Maturation ◽  
Circuit Development ◽  
Activity Dependent

GABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development, also recent studies involve a number of molecular players involved in the process. Emphasizing the molecular mechanisms of GABAergic synapse formation, in particular basket cell perisomatic synapses, this paper draws attention to the links between critical period plasticity, GABAergic synapse maturation, and the consequences of its dysfunction on the development of the nervous system.

ISDN2014_0202: Role of the neurotrophin receptor p75NTR in GABAergic synapse maturation in neocortex

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 59-59
Author(s):  
Elie Baho ◽  
Bidisha Chattopadhyaya ◽  
Marisol Lavertu Jolin ◽  
Graziella Di Cristo
Keyword(s):  
Neurotrophin Receptor ◽  
Gabaergic Synapse ◽  
Synapse Maturation

PENGARUH PERSONAL BACKGROUND, POLITICAL BACKGROUND DAN PENGEATAHUAN DEWAN TENTANG ANGGARAN TERHADAP PERAN DPRD DALAM PENGAWASAN KEUANGAN DAERAH

2008 ◽  
Author(s):  
Yesi Mutia Basri ◽  
Rosliana Rosliana
Keyword(s):  
Multivariate Analysis ◽  
Significant Influence ◽  
Political Activity ◽  
Primary Data ◽  
Financial Control ◽  
Independent Variables ◽  
Dependent Variables ◽  
Political Background ◽  
Activity Dependent

This research aim to examine the influence of personal background, political background, and council budget knowledge towards the role of DPRD on region financial control. This research is motivated by the fact that individual background will effect to individual behavior on political activity. Dependent variables in this research are personal background, political background, and council budges knowledge towards the role of DPRD on region financial control Independent variables are the role of DPRD on region financial control in planning, implementing, and responsibility steps. The data in this research consist of primary data that taken from questionnaires distributed directly to respondents. The collected are from 34 Respondents that members of DPRD at Pekanbaru. Hypothesis of this research are examine by using Multivariate Analysis of Variances (MANOVA). The result of this research HI personal background political background and budget knowledge have significant influence toward the role of DPRD on region financial control in planning steps.H2 personal background, politico I background and budget knowledge have no significant influence toward the role of DPRD on region financial control in Implementing steps. H3 personal background political background and budget knowledge have no significant influence toward the role of DPRD on region financial control in Controlling steps.

scholarly journals The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex

2017 ◽  
Vol 37 (28) ◽  
pp. 6628-6637 ◽  
Author(s):  
Nisha S. Pulimood ◽  
Wandilson dos Santos Rodrigues ◽  
Devon A. Atkinson ◽  
Sandra M. Mooney ◽  
Alexandre E. Medina
Keyword(s):  
Visual Cortex ◽  
Neuronal Plasticity ◽  
Activity Dependent

The role of ZIF268/EGR-1 during activity-dependent plasticity of developing visual cortex

1998 ◽  
Vol 31 ◽  
pp. S324
Author(s):  
Nobuko Mataga ◽  
Brian G. Condie ◽  
Sayaka Fujishima ◽  
Takao K. Hensch
Keyword(s):  
Visual Cortex ◽  
Dependent Plasticity ◽  
Activity Dependent

scholarly journals AMPA receptor inhibition by synaptically released zinc

2015 ◽  
Vol 112 (51) ◽  
pp. 15749-15754 ◽  
Author(s):  
Bopanna I. Kalappa ◽  
Charles T. Anderson ◽  
Jacob M. Goldberg ◽  
Stephen J. Lippard ◽  
Thanos Tzounopoulos
Keyword(s):  
Dorsal Cochlear Nucleus ◽  
Fine Tuning ◽  
Receptor Inhibition ◽  
Endogenous Modulator ◽  
Excitatory Neurotransmission ◽  
Zinc Levels ◽  
Zinc Inhibition ◽  
Endogenous Modulators ◽  
Activity Dependent

The vast amount of fast excitatory neurotransmission in the mammalian central nervous system is mediated by AMPA-subtype glutamate receptors (AMPARs). As a result, AMPAR-mediated synaptic transmission is implicated in nearly all aspects of brain development, function, and plasticity. Despite the central role of AMPARs in neurobiology, the fine-tuning of synaptic AMPA responses by endogenous modulators remains poorly understood. Here we provide evidence that endogenous zinc, released by single presynaptic action potentials, inhibits synaptic AMPA currents in the dorsal cochlear nucleus (DCN) and hippocampus. Exposure to loud sound reduces presynaptic zinc levels in the DCN and abolishes zinc inhibition, implicating zinc in experience-dependent AMPAR synaptic plasticity. Our results establish zinc as an activity-dependent, endogenous modulator of AMPARs that tunes fast excitatory neurotransmission and plasticity in glutamatergic synapses.

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