scholarly journals Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development

2008 ◽  
Vol 586 (9) ◽  
pp. 2371-2379 ◽  
Author(s):  
Paula M. Costello ◽  
Anthea Rowlerson ◽  
Nur Aida Astaman ◽  
Fred Erick W. Anthony ◽  
Avan Aihie Sayer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
Late Gestation ◽  
Skeletal Muscle Development ◽  
Fetal Sheep ◽  
Maternal Undernutrition

scholarly journals Analysis of dynamic and widespread lncRNA and miRNA expression in fetal sheep skeletal muscle

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9957
Author(s):  
Chao Yuan ◽  
Ke Zhang ◽  
Yaojing Yue ◽  
Tingting Guo ◽  
Jianbin Liu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
Expression Profiles ◽  
Muscle Growth ◽  
Skeletal Muscle Development ◽  
Fetal Sheep ◽  
Lncrna Gene ◽  
Skeletal Muscle Growth ◽  
Wide Range ◽  
Non Coding Rnas

The sheep is an economically important animal, and there is currently a major focus on improving its meat quality through breeding. There are variations in the growth regulation mechanisms of different sheep breeds, making fundamental research on skeletal muscle growth essential in understanding the regulation of (thus far) unknown genes. Skeletal muscle development is a complex biological process regulated by numerous genes and non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). In this study, we used deep sequencing data from sheep longissimus dorsi (LD) muscles sampled at day 60, 90, and 120 of gestation, as well as at day 0 and 360 following birth, to identify and examine the lncRNA and miRNA temporal expression profiles that regulate sheep skeletal myogenesis. We stained LD muscles using histological sections to analyse the area and circumference of muscle fibers from the embryonic to postnatal development stages. Our results showed that embryonic skeletal muscle growth can be characterized by time. We obtained a total of 694 different lncRNAs and compared the differential expression between the E60 vs. E90, E90 vs. E120, E120 vs. D0, and D0 vs. D360 lncRNA and gene samples. Of the total 701 known sheep miRNAs we detected, the following showed a wide range of expression during the embryonic stage: miR-2387, miR-105, miR-767, miR-432, and miR-433. We propose that the detected lncRNA expression was time-specific during the gestational and postnatal stages. GO and KEGG analyses of the genes targeted by different miRNAs and lncRNAs revealed that these significantly enriched processes and pathways were consistent with skeletal muscle development over time across all sampled stages. We found four visual lncRNA–gene regulatory networks that can be used to explore the function of lncRNAs in sheep and may be valuable in helping improve muscle growth. This study also describes the function of several lncRNAs that interact with miRNAs to regulate myogenic differentiation.

scholarly journals PSXI-34 Supplementation of grazing Nellore beef heifers during mid-to-late gestation as a strategy to improve skeletal muscle development of the offspring

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 401-402
Author(s):  
Rones G De Paula ◽  
Joanis T Zervoudakis ◽  
Luciana K Hatamoto-Zervoudakis ◽  
Marcos A Souza ◽  
Nelcino F De Paula ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fibre ◽  
Muscle Development ◽  
Late Gestation ◽  
The Other ◽  
Skeletal Muscle Development ◽  
Beef Heifers ◽  
Fiber Volume ◽  
Randomized Design ◽  
And Performance

Abstract The aim of this study was to evaluate supplementation effects of grazing heifers during mid-to-late of gestation on skeletal muscle development and performance of the progeny until weaning. One hundred and eighty Nellore beef heifers confirmed pregnant (timed AI) to a single sire were allotted to a completely randomized design with 2 treatments. Ninety heifers were fed only mineral (control) and the other 90 were fed a protein supplement (44.5% CP, 0.15% BW) from 90 to 274 days of gestation. Cows were grazed on Urochloa brizantha cv. Marandu pastures (5% CP and 64% NDF). At calving, cow–calf pairs were commingled and grazed on the same pasture until weaning. At 30 days after birth, a biopsy was performed to obtain samples of skeletal muscle tissue (Semitendinosus) from calves to determine the number and size of muscle fibre. Least squares mean for all data were computed using PROC MIXED of SAS (SAS Inst. Inc., Cary, NC). Calves from heifers supplemented with protein had greater birth BW (P < 0.001), ADG (P = 0.0147) and BW at 155 d (P = 0.0016) compared with calves from heifers not supplemented. However, calf BW at weaning (P = 0.1508) and gain from birth to weaning (P = 0.1446) did not differ. On the other hand, calves born from dams supplemented with protein had greater muscle fibre number (P = 0.0262), larger diameter of the fiber (P < 0.001), and smaller diameter of the fiber (P < 0.001) compared with calves from heifers not supplemented, although did not differ for mean fiber diameter (P = 0.8079). Fiber volume, fiber perimeter, and volume/area ratio were also affected (P < 0.001) by prepartum supplementation, and were greater on calves whose dams were fed with protein. In conclusion, supplementation of pregnant Nellore heifers with protein during the dry season improves calf birth BW, and promotes hyperplasia and hypertrophy in the skeletal muscle of the offspring.

scholarly journals Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 835
Author(s):  
Mohammadreza Mohammadabadi ◽  
Farhad Bordbar ◽  
Just Jensen ◽  
Min Du ◽  
Wei Guo
Keyword(s):  
Skeletal Muscle ◽  
Candidate Genes ◽  
Meat Quality ◽  
Muscle Development ◽  
Muscle Growth ◽  
Farm Animals ◽  
Meat Production ◽  
Skeletal Muscle Development ◽  
Extrinsic Factors ◽  
Myogenic Regulatory Factor

Farm-animal species play crucial roles in satisfying demands for meat on a global scale, and they are genetically being developed to enhance the efficiency of meat production. In particular, one of the important breeders’ aims is to increase skeletal muscle growth in farm animals. The enhancement of muscle development and growth is crucial to meet consumers’ demands regarding meat quality. Fetal skeletal muscle development involves myogenesis (with myoblast proliferation, differentiation, and fusion), fibrogenesis, and adipogenesis. Typically, myogenesis is regulated by a convoluted network of intrinsic and extrinsic factors monitored by myogenic regulatory factor genes in two or three phases, as well as genes that code for kinases. Marker-assisted selection relies on candidate genes related positively or negatively to muscle development and can be a strong supplement to classical selection strategies in farm animals. This comprehensive review covers important (candidate) genes that regulate muscle development and growth in farm animals (cattle, sheep, chicken, and pig). The identification of these genes is an important step toward the goal of increasing meat yields and improves meat quality.

Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy

Gene ◽  
2021 ◽  
Vol 783 ◽  
pp. 145562
Author(s):  
Huadong Yin ◽  
Shunshun Han ◽  
Can Cui ◽  
Yan Wang ◽  
Diyan Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wnt Signaling ◽  
Muscle Development ◽  
Skeletal Muscle Development

scholarly journals Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity

2011 ◽  
Vol 26 (2) ◽  
pp. 748-756 ◽  
Author(s):  
Laurence Pessemesse ◽  
Audrey Schlernitzauer ◽  
Chamroeun Sar ◽  
Jonathan Levin ◽  
Stéphanie Grandemange ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
Skeletal Muscle Development
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