scholarly journals Human cutaneous reactive hyperaemia: role of BKCachannels and sensory nerves

2007 ◽  
Vol 585 (1) ◽  
pp. 295-303 ◽  
Author(s):  
Santiago Lorenzo ◽  
Christopher T. Minson
Keyword(s):  
Sensory Nerves ◽  
Reactive Hyperaemia

Role of Exercise Activity in Alleviating Neuropathic Pain in Diabetes via Inhibition of the Pro-Inflammatory Signal Pathway

2018 ◽  
Vol 21 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Xiao-Qiu Ma ◽  
Jing Qin ◽  
Hong-Yan Li ◽  
Xiu-Li Yan ◽  
Yong Zhao ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Tumor Necrosis ◽  
Signal Pathway ◽  
Sensory Nerves ◽  
Glucose Levels ◽  
Tnf Α ◽  
Exercise Activity ◽  
Necrosis Factor ◽  
Pro Inflammatory Cytokines

Hyperalgesia and allodynia are commonly observed in patients with diabetic neuropathy. The treatment and management of painful peripheral neuropathy is important in these patients. The purpose of this study was to examine the role of exercise in modulating neuropathic pain induced by diabetes. Diabetes was induced in rats by an intraperitoneal injection of streptozotocin (STZ). Control rats received saline injections. Groups included control rats without exercise (NT-control, n = 12), control rats with exercise (EX-control, n = 16), STZ rats without exercise (NT-STZ, n = 18), and STZ rats with exercise (EX-STZ, n = 22). Rats in EX groups ran on a treadmill 4 days/week for 5 weeks beginning from the week of STZ administration. Mechanical hypersensitivity (mechanical paw withdrawal thresholds [PWTs]) and glucose levels were tested weekly. Then, enzyme-linked immunoassay and Western blot analysis were used to determine the levels of pro-inflammatory cytokines (PICs) and their receptors in sensory nerves. PWTs were significantly increased after 4–5 weeks of exercise in STZ rats ( p < .05 vs. NT-STZ rats). Inhibition of neuropathic pain by exercise in STZ rats was accompanied by decreases in interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α levels and downregulated expression of their receptors. Furthermore, blocking individual PIC receptors elevated PWTs to a greater degree in STZ rats ( p < .05 vs. control rats). Overall, our data suggest that exercise can play a role in improving neuropathic pain induced by STZ and that PIC signaling is a part of the mechanism involved in this effect.

Gastroprotective and vasodilatory effects of epidermal growth factor: the role of sensory afferent neurons

2001 ◽  
Vol 280 (5) ◽  
pp. G897-G903 ◽  
Author(s):  
Yoji Matsumoto ◽  
Kohki Kanamoto ◽  
Keishi Kawakubo ◽  
Hitoshi Aomi ◽  
Takayuki Matsumoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mucosal Injury ◽  
Protective Role ◽  
Sensory Nerves ◽  
Afferent Neurons ◽  
Gastric Mucosal Lesions ◽  
Calcitonin Gene ◽  
Epidermal Growth

Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the release of calcitonin gene-related peptide (CGRP). We examined the protective and vasodilatory effects of EGF on the gastric mucosa and its interaction with sensory nerves, CGRP, and nitric oxide (NO) in anesthetized rats. Intragastric EGF (10 or 30 μg) significantly reduced gastric mucosal lesions induced by intragastric 60% ethanol (50.6% by 10 μg EGF and 70.0% by 30 μg EGF). The protective effect of EGF was significantly inhibited by pretreatment with capsaicin desensitization, human CGRP1 antagonist hCGRP-(8–37), or N ω-nitro-l-arginine methyl ester (l-NAME). Intravital microscopy showed that topically applied EGF (10–1,000 μg/ml) dilated the gastric mucosal arterioles dose dependently and that this vasodilatory effect was significantly inhibited by equivalent pretreatments. These findings suggest that EGF plays a protective role against ethanol-induced gastric mucosal injury, possibly by dilating the gastric mucosal arterioles via capsaicin-sensitive afferent neurons involving CGRP and NO mechanisms.

Hydrogen Sulfide Mediated Inhibitory Neurotransmission to the Pig Bladder Neck: Role of K ATP Channels, Sensory Nerves and Calcium Signaling

2013 ◽  
Vol 190 (2) ◽  
pp. 746-756 ◽  
Author(s):  
Vítor S. Fernandes ◽  
Ana S.F. Ribeiro ◽  
María Victoria Barahona ◽  
Luis M. Orensanz ◽  
Ana Martínez-Sáenz ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Calcium Signaling ◽  
Bladder Neck ◽  
Sensory Nerves ◽  
Inhibitory Neurotransmission

Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide

1999 ◽  
Vol 374 (2) ◽  
pp. 263-276 ◽  
Author(s):  
Tomasz Brzozowski ◽  
Peter Ch Konturek ◽  
Stanisław J Konturek ◽  
Robert Pajdo ◽  
Aleksandra Duda ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Sensory Nerves

Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves

2008 ◽  
Vol 591 (1-3) ◽  
pp. 284-292 ◽  
Author(s):  
Artur Dembiński ◽  
Zygmunt Warzecha ◽  
Piotr Ceranowicz ◽  
Anna M. Warzecha ◽  
Wiesław W. Pawlik ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Protective Effect ◽  
Sensory Nerves ◽  
Time Dependent
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