scholarly journals Mechanisms of skeletal muscle injury and repair revealed by gene expression studies in mouse models

2007 ◽  
Vol 582 (2) ◽  
pp. 825-841 ◽  
Author(s):  
Gordon L. Warren ◽  
Mukesh Summan ◽  
Xin Gao ◽  
Rebecca Chapman ◽  
Tracy Hulderman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Mouse Models ◽  
Muscle Injury ◽  
Skeletal Muscle Injury ◽  
Expression Studies ◽  
Gene Expression Studies ◽  
Injury And Repair

Skeletal muscle injury and repair: A role for complement

2018 ◽  
Vol 102 ◽  
pp. 165
Author(s):  
Erin Jacobs ◽  
Carolina Ortiz ◽  
Edouard Al-Chami ◽  
Mohsen Afshar ◽  
Clinton Robbins ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Skeletal Muscle Injury ◽  
Injury And Repair

scholarly journals Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation

2018 ◽  
Author(s):  
Simon McArthur ◽  
Thomas Gobbetti ◽  
Gaëtan Juban ◽  
Thibaut Desgeorges ◽  
Marine Theret ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Muscle Fibres ◽  
Annexin A1 ◽  
Skeletal Muscle Injury ◽  
Cellular Processes ◽  
Reparative Process ◽  
Injury And Repair ◽  
Inflammation Resolution

SummaryUnderstanding the circuits that promote an efficient resolution of inflammation is crucial to deciphering the molecular and cellular processes required to promote tissue repair. Macrophages play a central role in the regulation of inflammation, resolution and repair/regeneration. Using a model of skeletal muscle injury and repair, herein we identify Annexin A1 (AnxA1) as the extracellular trigger of macrophage skewing towards a pro-reparative phenotype. Brought into the injured tissue initially by migrated neutrophils, and then over-expressed in infiltrating macrophages, AnxA1 activates FPR2/ALX receptors and the downstream AMPK signalling cascade leading to macrophage skewing, dampening of inflammation and regeneration of muscle fibres. Mice lacking AnxA1 in all cells or in myeloid cells only display a defect in this reparative process.In vitroexperiments recapitulated these properties, with AMPK null macrophages lacking AnxA1-mediated polarization. Collectively, these data identify the AnxA1/FPR2/AMPK axis as a novel pathway in skeletal muscle injury regeneration.

Selection of reference genes for gene expression studies in porcine skeletal muscle using SYBR green qPCR

2010 ◽  
Vol 150 (3) ◽  
pp. 288-293 ◽  
Author(s):  
Xiaoting Feng ◽  
Yuanzhu Xiong ◽  
Hui Qian ◽  
Minggang Lei ◽  
Dequan Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Reference Genes ◽  
Sybr Green ◽  
Expression Studies ◽  
Gene Expression Studies ◽  
Selection Of
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