scholarly journals Alternative splicing of the Cav2.2 subunit: a change in N-type calcium channel activity for which purpose?

2007 ◽  
Vol 580 (2) ◽  
pp. 361-362
Author(s):  
Norbert Weiss
Keyword(s):  
Alternative Splicing ◽  
Calcium Channel ◽  
Channel Activity ◽  
Subunit A

scholarly journals Courtship and Visual Defects of cacophony Mutants Reveal Functional Complexity of a Calcium-Channel α1 Subunit in Drosophila

Genetics ◽  
1998 ◽  
Vol 149 (3) ◽  
pp. 1407-1426 ◽  
Author(s):  
Lee A Smith ◽  
Alexandre A Peixoto ◽  
Elena M Kramer ◽  
Adriana Villella ◽  
Jeffrey C Hall
Keyword(s):  
Alternative Splicing ◽  
Calcium Channels ◽  
Calcium Channel ◽  
Stop Codon ◽  
Biological Functions ◽  
Visual Defects ◽  
Transcript Diversity ◽  
Functional Complexity ◽  
Α1 Subunit ◽  
Subtle Abnormality

Abstract We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel α1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associated with this gene. The cacS mutant, which exhibits defects in the patterning of courtship lovesong and a newly revealed but subtle abnormality in visual physiology, is mutated such that a highly conserved phenylalanine (in one of the quasi-homologous intrapolypeptide regions called IIIS6) is replaced by isoleucine. The cacH18 mutant exhibits defects in visual physiology (including complete unresponsiveness to light in certain genetic combinations) and visually mediated behaviors; this mutant (originally nbAH18) has a stop codon in an alternative exon (within the cac ORF), which is differentially expressed in the eye. Analysis ofthe various courtship and visual phenotypes associated with this array ofcac mutants demonstrates that Dmca1A calcium channels mediate multiple, separable biological functions; these correlate in part with transcript diversity generated via alternative splicing.

scholarly journals Glucose-6-Phosphate Dehydrogenase and NADPH Redox Regulates Cardiac Myocyte L-Type Calcium Channel Activity and Myocardial Contractile Function

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e45365 ◽  
Author(s):  
Dhwajbahadur K. Rawat ◽  
Peter Hecker ◽  
Makino Watanabe ◽  
Sukrutha Chettimada ◽  
Richard J. Levy ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Cardiac Myocyte ◽  
Contractile Function ◽  
Channel Activity ◽  
Myocardial Contractile ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Peptide potentiation of calcium channel activity can be seasonally variable

1991 ◽  
Vol 156 (1) ◽  
pp. 607-610
Author(s):  
CA Bishop ◽  
ME Krouse ◽  
JJ Wine
Keyword(s):  
Calcium Channel ◽  
Channel Activity

Synexin: Molecular Mechanism of Calcium-Dependent Membrane Fusion and Voltage-Dependent Calcium-Channel Activity.

1991 ◽  
Vol 635 (1 Calcium Entry) ◽  
pp. 328-351 ◽  
Author(s):  
HARVEY B. POLLARD ◽  
EDUARDO ROJAS ◽  
RICHARD W. PASTOR ◽  
EDUARDO M. ROJAS ◽  
H. ROBERT GUY ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Membrane Fusion ◽  
Molecular Mechanism ◽  
Channel Activity ◽  
Calcium Dependent ◽  
Voltage Dependent Calcium Channel ◽  
Voltage Dependent
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