scholarly journals Axonal and somatic filtering of antidromically evoked cortical excitation by simulated deep brain stimulation in rat brain

2007 ◽  
Vol 579 (2) ◽  
pp. 403-412 ◽  
Author(s):  
T. Chomiak ◽  
B. Hu
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Brain Stimulation ◽  
Cortical Excitation ◽  
Deep Brain

PET functional imaging of deep brain stimulation in the healthy rat brain

2014 ◽  
Vol 45 (01) ◽  
Author(s):  
N Van Den Berge ◽  
V Keereman ◽  
C Vanhove ◽  
P van Mierlo ◽  
B Van Nieuwenhuyse ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Functional Imaging ◽  
Brain Stimulation ◽  
Deep Brain

Simultaneous deep brain stimulation and functional MRI of the healthy rat brain

2015 ◽  
Vol 8 (2) ◽  
pp. 351-352
Author(s):  
N. Van Den Berge ◽  
I. Dauwe ◽  
C. vanhove ◽  
B. Descamps ◽  
P. Van Mierlo ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Functional Mri ◽  
Brain Stimulation ◽  
Deep Brain

Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain

2014 ◽  
Vol 17 (3) ◽  
pp. 373-383 ◽  
Author(s):  
Nathalie Van Den Berge ◽  
Vincent Keereman ◽  
Christian Vanhove ◽  
Bregt Van Nieuwenhuyse ◽  
Pieter van Mierlo ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Brain Stimulation ◽  
Glucose Utilization ◽  
Deep Brain

scholarly journals Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133245 ◽  
Author(s):  
Nathalie Van Den Berge ◽  
Christian Vanhove ◽  
Benedicte Descamps ◽  
Ine Dauwe ◽  
Pieter van Mierlo ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Functional Mri ◽  
Brain Stimulation ◽  
Deep Brain

scholarly journals Basal Forebrain Deep Brain Stimulation Impacts the Regulation of Extracellular Vesicle Related Proteins in the Rat Brain

2018 ◽  
Author(s):  
Wenxue Li ◽  
Laura Lozano Montes ◽  
Jayakrishnan Nair ◽  
Marta Dimanico ◽  
Reza Mazloum ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Brain Stimulation ◽  
Basal Forebrain ◽  
Extracellular Vesicle ◽  
Long Distance ◽  
Therapeutic Benefits ◽  
Neural Ensemble ◽  
Associated Proteins ◽  
Deep Brain

AbstractExtracellular vesicle (EV) signaling has attracted considerable attention in recent years because EVs play a key role in long distance cellular communication functions. EV studies have begun to reveal aspects of physiological and physiopathological regulation in numerous applications, although many areas remain to date largely unexplored. Deep brain stimulation (DBS) has shown remarkable therapeutic benefits of patients with neuropsychiatric disorders, but despite of the long and successful history of use, the mechanisms of action on neural ensemble activity are not yet fully understood. Here we explore how DBS of the basal forebrain impacts EV signaling in the rat brain. We employed differential centrifugations to isolate the EVs prefrontal cortex (PFC), hippocampus and striatum. We then performed quantitative analysis of EV-associated proteins using an MS-based proteomics method. We identified a considerable number of EV-associated proteins are modulated by DBS in three brain regions, some of which have been previously linked with central nervous system disorders. Particularly, neurofilament proteins NFL and NFM were both significantly changed in EVs of PFC, hippocampus and striatum after DBS stimulation compared with controls. The SOD1 protein, associated previously with neurodegenerative diseases, was significantly increased only in PFC. Our study is the first, to our knowledge, to use EV protein analysis to examine DBS effects on brain physiological regulation. Our findings open an entirely new perspective on brain area specific DBS effects.

scholarly journals Human Subthalamic Neuron Spiking Exhibits Subtle Responses to Sedatives

2011 ◽  
Vol 115 (2) ◽  
pp. 254-264 ◽  
Author(s):  
M. Bruce MacIver ◽  
Helen M. Bronte-Stewart ◽  
Jaimie M. Henderson ◽  
Richard A. Jaffe ◽  
John G. Brock-Utne
Keyword(s):  
Deep Brain Stimulation ◽  
Rat Brain ◽  
Brain Stimulation ◽  
Interval Analysis ◽  
Brain Slices ◽  
Implant Surgery ◽  
Microelectrode Recordings ◽  
Discharge Activity ◽  
Subthalamic Neurons ◽  
Deep Brain

Background During deep brain stimulation implant surgery, microelectrode recordings are used to map the location of targeted neurons. The effects produced by propofol or remifentanil on discharge activity of subthalamic neurons were studied intraoperatively to determine whether they alter neuronal activity. Methods Microelectrode recordings from 11 neurons, each from individual patients, were discriminated and analyzed before and after administration of either propofol or remifentanil. Subthalamic neurons in rat brain slices were recorded in patch-clamp to investigate cellular level effects. Results Neurons discharged at 42 ± 9 spikes/s (mean ± SD) and showed a common pattern of inhibition that lasted 4.3 ms. Unique discharge profiles were evident for each neuron, seen using joint-interval analysis. Propofol (intravenous bolus 0.3 mg/kg) produced sedation, with minor effects on discharge activity (less than 2.0% change in frequency). A prolongation of recurrent inhibition was evident from joint-interval analysis, and propofol's effect peaked within 2 min, with recovery evident at 10 min. Subthalamic neurons recorded in rat brain slices exhibited inhibitory synaptic currents that were prolonged by propofol (155%) but appeared to lack tonic inhibitory currents. Propofol did not alter membrane potential, membrane resistance, current-evoked discharge, or holding current during voltage clamp. Remifentanil (0.05 mg/kg) had little effect on overall subthalamic neuron discharge activity and did not prolong recurrent inhibition. Conclusions These results help to characterize the circuit properties and feedback inhibition of subthalamic neurons and demonstrate that both propofol and remifentanil produce only minor alterations of subthalamic neuron discharge activity that should not interfere with deep brain stimulation implant surgery.

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