scholarly journals Calpain regulation of AMPA receptor channels in cortical pyramidal neurons

2007 ◽  
Vol 580 (1) ◽  
pp. 241-254 ◽  
Author(s):  
Eunice Y. Yuen ◽  
Zhenglin Gu ◽  
Zhen Yan
Keyword(s):  
Ampa Receptor ◽  
Pyramidal Neurons ◽  
Cortical Pyramidal Neurons ◽  
Ampa Receptor Channels

Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice

2020 ◽  
Vol 12 (570) ◽  
pp. eabc1492
Author(s):  
Lawrence S. Hsieh ◽  
John H. Wen ◽  
Lena H. Nguyen ◽  
Longbo Zhang ◽  
Stephanie A. Getz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pyramidal Neurons ◽  
Focal Cortical Dysplasia ◽  
Repetitive Firing ◽  
Intracellular Camp ◽  
Main Role ◽  
Channel Activity ◽  
Mechanistic Target Of Rapamycin ◽  
Cortical Pyramidal Neurons ◽  
Causative Link

The causative link between focal cortical malformations (FCMs) and epilepsy is well accepted, especially among patients with focal cortical dysplasia type II (FCDII) and tuberous sclerosis complex (TSC). However, the mechanisms underlying seizures remain unclear. Using a mouse model of TSC- and FCDII-associated FCM, we showed that FCM neurons were responsible for seizure activity via their unexpected abnormal expression of the hyperpolarization-activated cyclic nucleotide–gated potassium channel isoform 4 (HCN4), which is normally not present in cortical pyramidal neurons after birth. Increasing intracellular cAMP concentrations, which preferentially affects HCN4 gating relative to the other isoforms, drove repetitive firing of FCM neurons but not control pyramidal neurons. Ectopic HCN4 expression was dependent on the mechanistic target of rapamycin (mTOR), preceded the onset of seizures, and was also found in diseased neurons in tissue resected from patients with TSC and FCDII. Last, blocking HCN4 channel activity in FCM neurons prevented epilepsy in the mouse model. These findings suggest that HCN4 play a main role in seizure and identify a cAMP-dependent seizure mechanism in TSC and FCDII. Furthermore, the unique expression of HCN4 exclusively in FCM neurons suggests that gene therapy targeting HCN4 might be effective in reducing seizures in FCDII or TSC.

scholarly journals Gonadal Hormones Modulate the Dendritic Spine Densities of Primary Cortical Pyramidal Neurons in Adult Female Rat

2009 ◽  
Vol 19 (11) ◽  
pp. 2719-2727 ◽  
Author(s):  
J.-R. Chen ◽  
Y.-T. Yan ◽  
T.-J. Wang ◽  
L.-J. Chen ◽  
Y.-J. Wang ◽  
...  
Keyword(s):  
Adult Female ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Gonadal Hormones ◽  
Female Rat ◽  
Cortical Pyramidal Neurons

scholarly journals The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10596 ◽  
Author(s):  
Ning Li ◽  
Chun-Tao Zhao ◽  
Ying Wang ◽  
Xiao-Bing Yuan
Keyword(s):  
Transcription Factor ◽  
Pyramidal Neurons ◽  
Dendritic Morphology ◽  
Cortical Pyramidal Neurons

Testosterone modulation of dendritic spines of somatosensory cortical pyramidal neurons

2013 ◽  
Vol 218 (6) ◽  
pp. 1407-1417 ◽  
Author(s):  
Jeng-Rung Chen ◽  
Tsyr-Jiuan Wang ◽  
Seh-Hong Lim ◽  
Yueh-Jan Wang ◽  
Guo-Fang Tseng
Keyword(s):  
Dendritic Spines ◽  
Pyramidal Neurons ◽  
Cortical Pyramidal Neurons
Sign in / Sign up

Export Citation Format

Share Document