scholarly journals Complex interplay between glutamate receptors and intracellular Ca2+stores during ischaemia in rat spinal cord white matter

2006 ◽  
Vol 577 (1) ◽  
pp. 191-204 ◽  
Author(s):  
Mohamed Ouardouz ◽  
Sameh Malek ◽  
Elaine Coderre ◽  
Peter K. Stys
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Glutamate Receptors ◽  
Rat Spinal Cord ◽  
Complex Interplay

scholarly journals Upregulation of EphA Receptor Expression in the Injured Adult Rat Spinal Cord

2002 ◽  
Vol 11 (3) ◽  
pp. 229-239 ◽  
Author(s):  
Christopher A. Willson ◽  
Margarita Irizarry-Ramírez ◽  
Hope E. Gaskins ◽  
Lillian Cruz-Orengo ◽  
Johnny D. Figueroa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Gray Matter ◽  
Receptor Expression ◽  
Axonal Guidance ◽  
Receptor Subtypes ◽  
Rat Spinal Cord ◽  
Functional Connections ◽  
Cord Injury ◽  
Epha Receptor

After spinal cord injury (SCI), the inability of supraspinal neurons to regenerate or reform functional connections is likely due to proteins in the surrounding microenvironment restricting regeneration. EphAs are a family of receptor tyrosine kinases that are involved in axonal guidance during development. These receptors and their ligands, the Ephrins, act via repulsive mechanisms to guide growing axons towards their appropriate targets and allow for the correct developmental connections to be made. In the present study, we investigated whether EphA receptor expression changed after a thoracic contusion SCI. Our results indicate that several EphA molecules are upregulated after SCI. Using semiquantitative RT-PCR to investigate mRNA expression after SCI, we found that EphA3, A4, and A7 mRNAs were upregulated. EphA3, A4, A6, and A8 receptor immunoreactivity increased in the ventrolateral white matter (VWM) at the injury epicenter. EphA7 had the highest level of immunoreactivity in both control and injured rat spinal cord. EphA receptor expression in the white matter originated from glial cells as coexpression in both astrocytes and oligodendrocytes was observed. In contrast, gray matter expression was localized to neurons of the ventral gray matter (motor neurons) and dorsal horn. After SCI, specific EphA receptor subtypes are upregulated and these increases may create an environment that is unfavorable for neurite outgrowth and functional regeneration.

scholarly journals In vivo DTI evaluation of white matter tracts in rat spinal cord

2006 ◽  
Vol 24 (1) ◽  
pp. 231-234 ◽  
Author(s):  
Jayaroop Gullapalli ◽  
Jaroslaw Krejza ◽  
Eric D. Schwartz
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Rat Spinal Cord ◽  
White Matter Tracts

Mechanisms for white matter damage in late radiation injury of the rat spinal cord

1989 ◽  
Vol 17 ◽  
pp. 162
Author(s):  
Kenneth J. Levin ◽  
Philip H. Gutin ◽  
Glenda Y. Ross ◽  
Theodore L. Phillips
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Radiation Injury ◽  
Rat Spinal Cord ◽  
White Matter Damage
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