scholarly journals Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress

2006 ◽  
Vol 575 (1) ◽  
pp. 229-239 ◽  
Author(s):  
Ganesh K. Kumar ◽  
Vandana Rai ◽  
Suresh D. Sharma ◽  
Devi Prasadh Ramakrishnan ◽  
Ying-Jie Peng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adrenal Medulla ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Adult Rat

scholarly journals Chronic intermittent hypoxia induces hypoxic sensitivity in adult rat adrenal medulla via oxidative stress

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Ganesh K Kumar ◽  
Vandana Rai ◽  
Suresh Sharma ◽  
DeviPrasadh Ramakrishnan ◽  
Ying‐Jie Peng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adrenal Medulla ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Adult Rat

scholarly journals Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia

2018 ◽  
Vol 66 (10) ◽  
pp. 753-765
Author(s):  
Esteban A. Moya ◽  
Paulina Arias ◽  
Rodrigo Iturriaga
Keyword(s):  
Oxidative Stress ◽  
Adrenal Gland ◽  
Enzymatic Activity ◽  
Adrenal Medulla ◽  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Sprague Dawley ◽  
Obstructive Sleep ◽  
Key Enzyme

Chronic intermittent hypoxia (CIH), main feature of obstructive sleep apnea, produces nitro-oxidative stress, which contributes to potentiate carotid body (CB) chemosensory discharges and sympathetic-adrenal-axis activity, leading to hypertension. The MnSOD enzymatic activity, a key enzyme on oxidative stress control, is reduced by superoxide-induced nitration. However, the effects of CIH-induced nitration on MnSOD enzymatic activity in the CB and adrenal gland are not known. We studied the effects of CIH on MnSOD protein and immunoreactive (MnSOD-ir) levels in the CB, adrenal gland and superior cervical ganglion (SCG), and on 3-nitrotyrosine (3-NT-ir), CuZnSOD (CuZnSOD-ir), MnSOD nitration, and its enzymatic activity in the CB and adrenal gland from male Sprague-Dawley rats exposed to CIH for 7 days. CIH increased 3-NT-ir in CB and adrenal gland, whereas MnSOD-ir increased in the CB and in adrenal cortex, but not in the whole adrenal medulla or SCG. CIH nitrated MnSOD in the CB and adrenal medulla, but its activity decreased in the adrenal gland. CuZnSOD-ir remained unchanged in both tissues. All changes observed were prevented by ascorbic acid treatment. Present results show that CIH for 7 days produced MnSOD nitration, but failed to reduce its activity in the CB, because of the increased protein level.

Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress

2018 ◽  
Vol 143 ◽  
pp. 225-233 ◽  
Author(s):  
Wenya Li ◽  
Shengchang Yang ◽  
Fu-Yang Yu ◽  
Yashuo Zhao ◽  
Zhi-Min Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intermittent Hypoxia ◽  
Neurocognitive Impairment ◽  
Chronic Intermittent Hypoxia

scholarly journals Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1184 ◽  
Author(s):  
Peng Guan ◽  
Zhi-Min Sun ◽  
Li-Fei Luo ◽  
Ya-Shuo Zhao ◽  
Sheng-Chang Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Overload ◽  
Renal Injury ◽  
Intermittent Hypoxia ◽  
Hydrogen Gas ◽  
Chronic Intermittent Hypoxia ◽  
Protective Effects ◽  
Divalent Metal Transporter 1 ◽  
Divalent Metal Transporter ◽  
And Oxidative Stress

Iron-induced oxidative stress has been found to be a central player in the pathogenesis of kidney injury. Recent studies have indicated H2 can be used as a novel antioxidant to protect cells. The present study was designed to investigate the protective effects of H2 against chronic intermittent hypoxia (CIH)-induced renal injury and its correlation mechanism involved in iron metabolism. We found that CIH-induced renal iron overloaded along with increased apoptosis and oxidative stress. Iron accumulates mainly occurred in the proximal tubule epithelial cells of rats as showed by Perl’s stain. Moreover, we found that CIH could promote renal transferrin receptor and divalent metal transporter-1 expression, inhibit ceruloplasmin expression. Renal injury, apoptosis and oxidative stress induced by CIH were strikingly attenuated in H2 treated rats. In conclusion, hydrogen may attenuate CIH-induced renal injury at least partially via inhibiting renal iron overload.

scholarly journals Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla

2015 ◽  
Vol 209 ◽  
pp. 115-119 ◽  
Author(s):  
Ganesh K. Kumar ◽  
Jayasri Nanduri ◽  
Ying-Jie Peng ◽  
Nanduri R. Prabhakar
Keyword(s):  
Adrenal Medulla ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia
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