scholarly journals Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin

2006 ◽  
Vol 572 (1) ◽  
pp. 295-305 ◽  
Author(s):  
José González-Alonso ◽  
Stefan P. Mortensen ◽  
Ellen A. Dawson ◽  
Niels H. Secher ◽  
Rasmus Damsgaard
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Delivery ◽  
Human Skeletal Muscle ◽  
Muscle Blood Flow ◽  
Erythrocyte Count ◽  
Skeletal Muscle Blood Flow

scholarly journals Local, but not indirect whole body heating, increases human skeletal muscle blood flow

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Illka Heinonen ◽  
R. Matthew Brothers ◽  
Jukka Kemppainen ◽  
Juhani Knuuti ◽  
Kari K. Kalliokoski ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Muscle Blood Flow ◽  
Whole Body ◽  
Skeletal Muscle Blood Flow

scholarly journals Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise

2002 ◽  
Vol 543 (2) ◽  
pp. 691-698 ◽  
Author(s):  
Robert Boushel ◽  
Henning Langberg ◽  
Carsten Gemmer ◽  
Jens Olesen ◽  
Regina Crameri ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Muscle Blood Flow ◽  
Skeletal Muscle Blood Flow

scholarly journals Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling

2018 ◽  
Vol 124 (1) ◽  
pp. 109-117 ◽  
Author(s):  
Peter Piil ◽  
Tue Smith Jørgensen ◽  
Jon Egelund ◽  
Rasmus Damsgaard ◽  
Lasse Gliemann ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Exercise Training ◽  
Oxidative Metabolism ◽  
Muscle Blood Flow ◽  
Older Men ◽  
Skeletal Muscle Blood Flow ◽  
Cgmp Signaling

Physical activity has the potential to offset age-related impairments in the regulation of blood flow and O2 delivery to the exercising muscles; however, the mechanisms underlying this effect of physical activity remain poorly understood. The present study examined the role of cGMP in training-induced adaptations in the regulation of skeletal muscle blood flow and oxidative metabolism during exercise in aging humans. We measured leg hemodynamics and oxidative metabolism during exercise engaging the knee extensor muscles in young [ n = 15, 25 ± 1 (SE) yr] and older ( n = 15, 72 ± 1 yr) subjects before and after a period of aerobic high-intensity exercise training. To determine the role of cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, inhibition of PDE5 increased ( P < 0.05) skeletal muscle blood flow and O2 uptake during moderate-intensity exercise in the older group; however, these effects of PDE5 inhibition were not detected after training. These findings suggest a role for enhanced cGMP signaling in the training-induced improvement of regulation of blood flow in contracting skeletal muscle of older men. NEW & NOTEWORTHY The present study provides evidence for enhanced cyclic GMP signaling playing an essential role in the improved regulation of blood flow in contracting skeletal muscle of older men with aerobic exercise training.

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