scholarly journals Na + ‐Ca 2+ Exchange Function Underlying Contraction Frequency Inotropy in the Cat Myocardium

2003 ◽  
Vol 550 (3) ◽  
pp. 801-817 ◽  
Author(s):  
Martín G. Vila Petroff ◽  
Julieta Palomeque ◽  
Alicia R. Mattiazzi
Keyword(s):  
Contraction Frequency ◽  
Exchange Function

CO2 and Lung Mechanical or Gas Exchange Function: The authors reply

2004 ◽  
Vol 32 (5) ◽  
pp. 1240-1241
Author(s):  
John G. Laffey ◽  
Brian P. Kavanagh
Keyword(s):  
Gas Exchange ◽  
Exchange Function

Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism

2007 ◽  
Vol 293 (1) ◽  
pp. H709-H718 ◽  
Author(s):  
Jerome W. Breslin ◽  
Nathalie Gaudreault ◽  
Katherine D. Watson ◽  
Rashell Reynoso ◽  
Sarah Y. Yuan ◽  
...  
Keyword(s):  
Stroke Volume ◽  
Stroke Volume Index ◽  
Volume Index ◽  
Flow Index ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Contraction Frequency ◽  
Pump Activity ◽  
Endothelial Growth Factor ◽  
Arteriolar Diameter

Vascular endothelial growth factor (VEGF)-C plays an important role in lymphangiogenesis; however, functional responses of lymphatic vessels to VEGF-C have not been characterized. We tested the hypothesis that VEGF-C-induced activation of VEGF receptor (VEGFR)-3 increases lymphatic pump output. We examined the in vivo pump activity of rat mesenteric collecting lymphatics using intravital microscopy during basal conditions and during treatment with 1 nM recombinant VEGF-C, the selective VEGFR-3 agonist VEGF-Cys156Ser mutation (C156S; 1 nM), or 0.1 nM VEGF-A. Their specific responses were also analyzed during selective inhibition of VEGFR-3 with MAZ-51. Contraction frequency, end-diastolic diameter, end-systolic diameter, stroke volume index, pump flow index, and ejection fraction were evaluated. We also assessed arteriolar diameter and microvascular extravasation of FITC-albumin. The results show that both VEGF-C and VEGF-C156S significantly increased contraction frequency, end-diastolic diameter, stroke volume index, and pump flow index in a time-dependent manner. VEGF-A caused a different response characterized by a significantly increased stroke volume after 30 min of treatment. MAZ-51 (5 μM) caused tonic constriction and decreased contraction frequency. In addition, 0.5 and 5 μM MAZ-51 attenuated VEGF-C- and VEGF-C156S-induced lymphatic pump activation. VEGF-A caused vasodilation of arterioles, whereas VEGF-C and VEGF-C156S did not significantly alter arteriolar diameter. Also, VEGF-A and VEGF-C caused increased microvascular permeability, whereas VEGF-C156S did not. Our results demonstrate that VEGF-C increases lymphatic pumping through VEGFR-3. Furthermore, changes in microvascular hemodynamics are not required for VEGFR-3-mediated changes in lymphatic pump activity.

Antioxidant and multi-sensitive PNIPAAm/keratin double network gels for self-stripping wound dressing application

2021 ◽  
Author(s):  
Xiao Han ◽  
Yang Rong ◽  
Xiuzhen Wan ◽  
Jie Dou ◽  
Jiang Yuan ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Absorptive Capacity ◽  
Wound Dressing ◽  
Tissue Fluid ◽  
Double Network ◽  
Humid Environment ◽  
Exchange Function

Hydrogel is a potential wound dressing material due to its ability to maintain a humid environment, the strong absorptive capacity of exuded tissue fluid, and gas exchange function. Herein, poly(N-isopropyl...

Uterine Contraction Frequency at the Time of Embryo Transfer (ET) Is Correlated With Anxiety Levels

2000 ◽  
Vol 74 (3) ◽  
pp. S252
Author(s):  
R Fanchin ◽  
S Gellman ◽  
C Righini ◽  
J.-M Ayoubi ◽  
F Olivennes ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Uterine Contraction ◽  
Contraction Frequency ◽  
Anxiety Levels

scholarly journals Gas Exchange Function of the Middle Ear Mucosa in Patients with Cleft Palate.

1998 ◽  
Vol 91 (3) ◽  
pp. 227-231
Author(s):  
Makito TANABE ◽  
Haruo Takahashi ◽  
Iwao HONJI ◽  
Masaki SAWADA
Keyword(s):  
Gas Exchange ◽  
Cleft Palate ◽  
Middle Ear ◽  
Middle Ear Mucosa ◽  
Exchange Function

Effects of Hypoxic Acclimation, Muscle Strain and Contraction Frequency on Nitric Oxide-Mediated Myocardial Performance in Steelhead Trout (Oncorhynchus mykiss)

2021 ◽  
Author(s):  
Christian Carnevale ◽  
Douglas A. Syme ◽  
A. Kurt Gamperl
Keyword(s):  
Nitric Oxide ◽  
Myocardial Contractility ◽  
Soluble Guanylyl Cyclase ◽  
Surprising Result ◽  
Muscle Strain ◽  
No Donor ◽  
Contraction Frequency ◽  
Mediated Effects ◽  
Oxide Synthase ◽  
Hypoxic Acclimation

Whether hypoxic acclimation influences nitric oxide (NO)-mediated control of fish cardiac function is not known. Thus, we measured the function / performance of myocardial strips from normoxia and hypoxia-acclimated (40% air saturation; ~ 8 kPa O2) trout at several frequencies (20 - 80 contractions min-1) and two muscle strain amplitudes (8 and 14%) when exposed to increasing concentrations of the NO donor sodium nitroprusside (SNP) (10-9 to 10-4 M). Further, we examined the influence of: 1) nitric oxide synthase (NOS) produced NO (by blocking NOS with 10-4 M L-NMMA); and 2) soluble guanylyl cyclase mediated, NOS-independent, NO effects (i.e., after blockade with 10-4 M ODQ), on myocardial contractility. Hypoxic acclimation increased twitch duration by 8-10% and decreased mass-specific net power by ~35%. However, hypoxic acclimation only had minor impacts on the effects of SNP and the two blockers on myocardial function. The most surprising result of this study was the degree to which contraction frequency and strain amplitude influenced NO-mediated effects on myocardial power. For example, at 8% strain 10-4 SNP resulted in a decrease in net power of ~30% at 20 min-1 but an increase of ~20% at 80 min-1, and this effect was magnified at 14% strain. This study: suggests that hypoxic acclimation has only minor effects on NO-mediated myocardial contractility in salmonids; is the first to report the highly frequency- and strain-dependent nature of NO effects on myocardial contractility in fishes; and supports previous work showing that NO effects on the heart (myocardium) are finely tuned spatio-temporally.

Sign in / Sign up

Export Citation Format

Share Document