scholarly journals The Plasma Membrane Calcium‐ATPase as a Major Mechanism for Intracellular Calcium Regulation in Neurones from the Rat Superior Cervical Ganglion

2003 ◽  
Vol 550 (1) ◽  
pp. 83-101 ◽  
Author(s):  
N. Wanaverbecq ◽  
S. J. Marsh ◽  
M. Al‐Qatari ◽  
D. A. Brown
Keyword(s):  
Plasma Membrane ◽  
Intracellular Calcium ◽  
Superior Cervical Ganglion ◽  
Calcium Regulation ◽  
Calcium Atpase ◽  
Plasma Membrane Calcium Atpase ◽  
Major Mechanism ◽  
Cervical Ganglion ◽  
Intracellular Calcium Regulation

scholarly journals The Effect of Vitamin D3 Supplementation on Intracellular Calcium and Plasma Membrane Calcium ATPase Activity in Early Stages of Chronic Kidney Disease

2014 ◽  
pp. S593-S599
Author(s):  
M. MORVOVÁ ◽  
I. LAJDOVÁ ◽  
V. SPUSTOVÁ ◽  
M. ZVARÍK ◽  
L. ŠIKUROVÁ
Keyword(s):  
Chronic Kidney Disease ◽  
Plasma Membrane ◽  
Kidney Disease ◽  
Healthy Volunteers ◽  
Intracellular Calcium ◽  
Vitamin D3 ◽  
Calcium Atpase ◽  
Plasma Membrane Calcium Atpase ◽  
Vitamin D3 Supplementation ◽  
The Impact

Chronic kidney disease (CKD) is associated with increased concentration of intracellular calcium, which is pathological and may lead to irreversible damage of cell functions and structures. The aim of our study was to investigate the impact of 6 months vitamin D3 supplementation (14 000 IU/week) on free cytosolic calcium concentration ([Ca2+]i) and on the plasma membrane calcium ATPase (PMCA) activity of patients with CKD stage 2-3. PMCA activity of patients was also compared to that of healthy volunteers. Vitamin D3 supplementation of CKD patients resulted in the decrease of [Ca2+]i (119.79±5.87 nmol/l vs. 105.36±3.59 nmol/l, n=14, P<0.001), whereas PMCA activity of CKD patients (38.75±22.89 nmol Pi/mg/h) remained unchanged after vitamin D3 supplementation (40.96±17.74 nmol Pi/mg/h, n=14). PMCA activity of early stage CKD patients before supplementation of vitamin D3, was reduced by 34 % (42.01±20.64 nmol Pi/mg/h) in comparison to healthy volunteers (63.68±20.32 nmol Pi/mg/h, n=28, P<0.001). These results indicate that vitamin D3 supplementation had a lowering effect on [Ca2+]i and negligible effect on PMCA activity in CKD patients.

Plasma Membrane Calcium ATPase Gene Expression in Bovine Lens Epithelium

2000 ◽  
Vol 32 (2-3) ◽  
pp. 100-105 ◽  
Author(s):  
Lijun Bian ◽  
Junwen Zeng ◽  
Douglas Borchman ◽  
Christopher A. Paterson
Keyword(s):  
Gene Expression ◽  
Plasma Membrane ◽  
Calcium Atpase ◽  
Lens Epithelium ◽  
Plasma Membrane Calcium Atpase ◽  
Bovine Lens ◽  
Atpase Gene
Sign in / Sign up

Export Citation Format

Share Document