scholarly journals Crucial Role of Sodium Channel Fast Inactivation in Muscle Fibre Inexcitability in a Rat Model of Critical Illness Myopathy

2003 ◽  
Vol 547 (2) ◽  
pp. 555-566 ◽  
Author(s):  
Mark M. Rich ◽  
Martin J. Pinter
Keyword(s):  
Critical Illness ◽  
Sodium Channel ◽  
Muscle Fibre ◽  
Rat Model ◽  
Crucial Role ◽  
Critical Illness Myopathy ◽  
Fast Inactivation

scholarly journals Altered sodium channel-protein associations in critical illness myopathy

2012 ◽  
Vol 2 (1) ◽  
pp. 17 ◽  
Author(s):  
Susan D Kraner ◽  
Kevin R Novak ◽  
Qingbo Wang ◽  
Junmin Peng ◽  
Mark M Rich
Keyword(s):  
Critical Illness ◽  
Sodium Channel ◽  
Critical Illness Myopathy ◽  
Channel Protein

scholarly journals Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model

2018 ◽  
Vol 225 (2) ◽  
pp. e13172 ◽  
Author(s):  
Hazem Akkad ◽  
Nicola Cacciani ◽  
Monica Llano-Diez ◽  
Rebeca Corpeno Kalamgi ◽  
Tamara Tchkonia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Critical Illness ◽  
Rat Model ◽  
Critical Illness Myopathy

scholarly journals The role of endotoxin in critical illness myopathy and polyneuropathy

2009 ◽  
Vol 256 (8) ◽  
pp. 1354-1354 ◽  
Author(s):  
Jörg Ahrens ◽  
Martin Leuwer ◽  
Nilufar Foadi ◽  
Gertrud Haeseler
Keyword(s):  
Critical Illness ◽  
Critical Illness Myopathy

Gap junctions–guards of excitability

2015 ◽  
Vol 43 (3) ◽  
pp. 508-512 ◽  
Author(s):  
Line Waring Stroemlund ◽  
Christa Funch Jensen ◽  
Klaus Qvortrup ◽  
Mario Delmar ◽  
Morten Schak Nielsen
Keyword(s):  
Sodium Channel ◽  
Crucial Role ◽  
Connexin 43 ◽  
Current Evidence ◽  
Intercalated Disc ◽  
Intercalated Discs ◽  
Cardiac Sodium Channel ◽  
Junctional Protein ◽  
Gap Junctional

Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.

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