scholarly journals Unravelling the role of the ryanodine receptor type 3 in smooth muscle

2002 ◽  
Vol 538 (3) ◽  
pp. 673-673 ◽  
Author(s):  
Rachel M. Tribe
Keyword(s):  
Smooth Muscle ◽  
Ryanodine Receptor ◽  
Receptor Type ◽  
Type 3

scholarly journals The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Channels ◽  
2014 ◽  
Vol 8 (3) ◽  
pp. 230-242 ◽  
Author(s):  
Jie Liu ◽  
Charlene Supnet ◽  
Suya Sun ◽  
Hua Zhang ◽  
Levi Good ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mouse Model ◽  
Ryanodine Receptor ◽  
Receptor Type ◽  
Type 3

scholarly journals Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain

2021 ◽  
Vol 12 ◽  
Author(s):  
Katarzyna Pawlik ◽  
Agata Ciechanowska ◽  
Katarzyna Ciapała ◽  
Ewelina Rojewska ◽  
Wioletta Makuch ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Chemokine Receptor ◽  
Pain Treatment ◽  
Opioid Analgesic ◽  
Receptor Type ◽  
Clinical Issue ◽  
Cc Chemokine ◽  
Type 3

Neuropathic pain is a serious clinical issue, and its treatment remains a challenge in contemporary medicine. Thus, dynamic development in the area of animal and clinical studies has been observed. The mechanisms of neuropathic pain are still not fully understood; therefore, studies investigating these mechanisms are extremely important. However, much evidence indicates that changes in the activation and infiltration of immune cells cause the release of pronociceptive cytokines and contribute to neuropathic pain development and maintenance. Moreover, these changes are associated with low efficacy of opioids used to treat neuropathy. To date, the role of CC chemokine receptor type 3 (CCR3) in nociception has not been studied. Similarly, little is known about its endogenous ligands (C-C motif ligand; CCL), namely, CCL5, CCL7, CCL11, CCL24, CCL26, and CCL28. Our research showed that the development of hypersensitivity in rats following chronic constriction injury (CCI) of the sciatic nerve is associated with upregulation of CCL7 and CCL11 in the spinal cord and dorsal root ganglia (DRG). Moreover, our results provide the first evidence that single and repeated intrathecal administration of the CCR3 antagonist SB328437 diminishes mechanical and thermal hypersensitivity. Additionally, repeated administration enhances the analgesic properties of morphine and buprenorphine following nerve injury. Simultaneously, the injection of SB328437 reduces the protein levels of some pronociceptive cytokines, such as IL-6, CCL7, and CCL11, in parallel with a reduction in the activation and influx of GFAP-, CD4- and MPO-positive cells in the spinal cord and/or DRG. Moreover, we have shown for the first time that an inhibitor of myeloperoxidase-4-aminobenzoic hydrazide may relieve pain and simultaneously enhance morphine and buprenorphine efficacy. The obtained results indicate the important role of CCR3 and its modulation in neuropathic pain treatment and suggest that it represents an interesting target for future investigations.

Ryanodine receptor type 3 (RYR3) as a novel gene associated with nemaline myopathy and fibre type disproportion

2016 ◽  
Vol 26 ◽  
pp. S137 ◽  
Author(s):  
Y. Nilipour ◽  
S. Nafissi ◽  
V. Varasteh ◽  
H. Hossein-Nejad ◽  
S. Tonekaboni ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Fibre Type ◽  
Nemaline Myopathy ◽  
Receptor Type ◽  
Novel Gene ◽  
Type 3

Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle

2005 ◽  
Vol 288 (3) ◽  
pp. C640-C649 ◽  
Author(s):  
Claudio F. Perez ◽  
José R. López ◽  
Paul D. Allen
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Tibialis Anterior ◽  
Muscle Fibers ◽  
Expression Levels ◽  
Cultured Myotubes ◽  
Increased Sensitivity ◽  
Type 3 ◽  
Different Levels

To better understand the role of the transient expression of ryanodine receptor (RyR) type 3 (RyR3) on Ca2+ homeostasis during the development of skeletal muscle, we have analyzed the effect of expression levels of RyR3 and RyR1 on the overall physiology of cultured myotubes and muscle fibers. Dyspedic myotubes were infected with RyR1 or RyR3 containing virions at 0.2, 0.4, 1.0, and 4.0 moieties of infection (MOI), and analysis of their pattern of expression, caffeine sensitivity, and resting free Ca2+ concentration ([Ca2+]r) was performed. Although increased MOI resulted in increased expression of each receptor isoform, it did not significantly affect the immunopattern of RyRs or the expression levels of calsequestrin, triadin, or FKBP-12. Interestingly, myotubes expressing RyR3 always had significantly higher [Ca2+]r and lower caffeine EC50 than did cells expressing RyR1. Although some of the increased sensitivity of RyR3 to caffeine could be attributed to the higher [Ca2+]r in RyR3-expressing cells, studies of [3H]ryanodine binding demonstrated intrinsic differences in caffeine sensitivity between RyR1 and RyR3. Tibialis anterior (TA) muscle fibers at different stages of postnatal development exhibited a transient increase in [Ca2+]r coordinately with their level of RyR3 expression. Similarly, adult soleus fibers, which also express RyR3, had higher [Ca2+]r than did adult TA fibers, which exclusively express RyR1. These data show that in skeletal muscle, RyR3 increases [Ca2+]r more than RyR1 does at any expression level. These data suggest that the coexpression of RyR1 and RyR3 at different levels may constitute a novel mechanism by which to regulate [Ca2+]r in skeletal muscle.

scholarly journals Generation and Characterization of Mutant Mice Lacking Ryanodine Receptor Type 3

1996 ◽  
Vol 271 (33) ◽  
pp. 19649-19652 ◽  
Author(s):  
Hiroshi Takeshima ◽  
Takaaki Ikemoto ◽  
Miyuki Nishi ◽  
Nobuyoshi Nishiyama ◽  
Misa Shimuta ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Mutant Mice ◽  
Receptor Type ◽  
Type 3

scholarly journals Facilitation of NMDAR-Independent LTP and Spatial Learning in Mutant Mice Lacking Ryanodine Receptor Type 3

Neuron ◽  
1999 ◽  
Vol 24 (3) ◽  
pp. 701-713 ◽  
Author(s):  
Akira Futatsugi ◽  
Kunio Kato ◽  
Hiroo Ogura ◽  
Sheng-Tian Li ◽  
Eiichiro Nagata ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Spatial Learning ◽  
Mutant Mice ◽  
Receptor Type ◽  
Type 3
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