scholarly journals Role of the medullary raphé in thermoregulatory vasomotor control in rats

2002 ◽  
Vol 540 (2) ◽  
pp. 657-664 ◽  
Author(s):  
Mutsumi Tanaka ◽  
Kei Nagashima ◽  
Robin M. McAllen ◽  
Kazuyuki Kanosue
Keyword(s):  
Vasomotor Control ◽  
Medullary Raphe

The role of the medullary raphe nuclei in regulation of cholinergic outflow to the airways

1998 ◽  
Vol 69 (1) ◽  
pp. 64-71 ◽  
Author(s):  
M.A. Haxhiu ◽  
B. Erokwu ◽  
V. Bhardwaj ◽  
I.A. Dreshaj
Keyword(s):  
Raphe Nuclei ◽  
Medullary Raphe ◽  
Raphé Nuclei

Role of serotonergic neurons in the maintenance of the 10-Hz rhythm in sympathetic nerve discharge

1996 ◽  
Vol 270 (1) ◽  
pp. R174-R181 ◽  
Author(s):  
H. S. Orer ◽  
M. E. Clement ◽  
S. M. Barman ◽  
S. Zhong ◽  
G. L. Gebber ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Peak Frequency ◽  
Inhibitory Effects ◽  
Receptor Agonists ◽  
Naturally Occurring ◽  
Medullary Raphe ◽  
Receptor Agonists And Antagonists ◽  
Raphe Neurons ◽  
Nerve Discharge

We studied the effects of serotonin (5-HT)-receptor agonists and antagonists on the naturally occurring 10-Hz rhythm in sympathetic nerve discharge (SND) of urethan-anesthetized, baroreceptor-denervated cats. Intravenous doses of the 5-HT1A-receptor agonists 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT) and U-93385E, which inhibit the firing of serotonergic medullary raphe neurons, decreased the power in the 10-Hz band of SND without affecting the power at frequencies < or = 6 Hz. The inhibitory effects of 8-OH-DPAT and U-93385E were reversed by the 5-HT1A-receptor antagonists spiperone and WAY-100135. Microinjection of 8-OH-DPAT into medullary raphe nuclei also selectively eliminated the 10-Hz rhythm in SND. Intravenous administration of the 5-HT2-receptor antagonist methysergide blocked the 10-Hz rhythm in SND, whereas the 5-HT2-receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane increased peak frequency and power in the 10-Hz band of SND. Microinjection of N-methyl-D-aspartic acid into the medullary raphe also enhanced the 10-Hz rhythm in SND. These data support the view that the naturally occurring discharges of serotonergic medullary raphe neurons preferentially enhance the 10-Hz rhythm in SND.

scholarly journals Role of vascular bed compliance in vasomotor control in human skeletal muscle

2007 ◽  
Vol 92 (5) ◽  
pp. 841-848 ◽  
Author(s):  
M. Zamir ◽  
R. Goswami ◽  
D. Salzer ◽  
J. K. Shoemaker
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Vasomotor Control ◽  
Vascular Bed

A role of nitric oxide in vasomotor control of cerebral parenchymal arterioles in rats

1994 ◽  
Vol 49 ◽  
pp. 63-66 ◽  
Author(s):  
Masakazu Takayasu ◽  
Yasukazu Kajita ◽  
Yoshio Suzuki ◽  
Masato Shibuya ◽  
Kenichiro Sugita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vasomotor Control

scholarly journals Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

2020 ◽  
pp. S151-S161
Author(s):  
L. Martvon ◽  
Z. Kotmanova ◽  
B. Dobrolubov ◽  
L. Babalova ◽  
M. Simera ◽  
...  
Keyword(s):  
Dominant Role ◽  
Gabab Receptors ◽  
Cough Reflex ◽  
Gating Mechanism ◽  
Multiple Receptors ◽  
Cough Response ◽  
Medullary Raphe ◽  
Nucleus Raphe Obscurus ◽  
Rostral Nucleus

We studied the effects of GABA receptor agonists microinjections in medullary raphé on the mechanically induced tracheobronchial cough response in anesthetized, unparalyzed, spontaneously breathing cats. The results suggest that GABA-ergic inhibition significantly contributes to the regulation of cough reflex by action of both GABAA and GABAB receptors. The data are consistent with inhomogeneous occurrence of GABA-ergic neurons in medullary raphé and their different involvement in the cough reflex control. Cells within rostral nucleus raphé obscurus with dominant role of GABAA receptors and neurons of rostral nucleus raphé pallidus and caudal nucleus raphé magnus with dominant role of GABAB receptors participate in regulation of cough expiratory efforts. These cough control elements are distinct from cough gating mechanism. GABA-ergic inhibition in the raphé caudal to obex had insignificant effect on cough. Contradictory findings for GABA, muscimol and baclofen administration in medullary raphé suggest involvement of coordinated activity of GABA on multiple receptors affecting raphé neurons and/or the local neuronal circuits in the raphé modulating cough motor drive.

GABAergic neurons of the medullary raphe regulate active expiration during hypercapnia

2020 ◽  
Vol 123 (5) ◽  
pp. 1933-1943 ◽  
Author(s):  
Josiane do N. Silva ◽  
Luiz M. Oliveira ◽  
Felipe C. Souza ◽  
Thiago S. Moreira ◽  
Ana C. Takakura
Keyword(s):  
Gabaergic Neurons ◽  
Medullary Raphe ◽  
Raphe Neurons

Medullary raphe has been involved in the inspiratory response to central chemoreflex; however, these reports have never addressed the role of raphe neurons on active expiration induced by hypercapnia. Here, we showed that a subset of GABA cells within the medullary raphe directly project to the parafacial respiratory region, modulating active expiration under high levels of CO2.

Role of Endogenous Bradykinin in Human Coronary Vasomotor Control

Circulation ◽  
1995 ◽  
Vol 92 (12) ◽  
pp. 3424-3430 ◽  
Author(s):  
Peter Groves ◽  
Sabine Kurz ◽  
Hanjörg Just ◽  
Helmut Drexler
Keyword(s):  
Vasomotor Control
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