scholarly journals External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.

1996 ◽  
Vol 494 (2) ◽  
pp. 431-442 ◽  
Author(s):  
J R Balser ◽  
H B Nuss ◽  
N Chiamvimonvat ◽  
M T Pérez-García ◽  
E Marban ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Slow Inactivation ◽  
Rat Skeletal Muscle

scholarly journals Coupling between fast and slow inactivation revealed by analysis of a point mutation (F1304Q) in mu 1 rat skeletal muscle sodium channels.

1996 ◽  
Vol 494 (2) ◽  
pp. 411-429 ◽  
Author(s):  
H B Nuss ◽  
J R Balser ◽  
D W Orias ◽  
J H Lawrence ◽  
G F Tomaselli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Point Mutation ◽  
Sodium Channels ◽  
Slow Inactivation ◽  
Rat Skeletal Muscle

scholarly journals Comparison of slow inactivation in human heart and rat skeletal muscle Na+channel chimaeras

1999 ◽  
Vol 515 (1) ◽  
pp. 61-73 ◽  
Author(s):  
John P. O'Reilly ◽  
Sho-Ya Wang ◽  
Roland G. Kallen ◽  
Ging Kuo Wang
Keyword(s):  
Skeletal Muscle ◽  
Human Heart ◽  
Na Channel ◽  
Slow Inactivation ◽  
Rat Skeletal Muscle

scholarly journals Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels

2000 ◽  
Vol 524 (1) ◽  
pp. 37-49 ◽  
Author(s):  
Zhenhui Chen ◽  
Boon‐Hooi Ong¹ ◽  
Nicholas G. Kambouris ◽  
Eduardo Marbán ◽  
Gordon F. Tomaselli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Rat Skeletal Muscle

Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle

Biochemistry ◽  
1987 ◽  
Vol 26 (24) ◽  
pp. 7546-7556 ◽  
Author(s):  
Xiaotao Guo ◽  
Akira Uehara ◽  
Arippa Ravindran ◽  
Shirley H. Bryant ◽  
Sherwood Hall ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Canine Heart ◽  
Rat Skeletal Muscle

scholarly journals Modification by ageing of the tetrodotoxin-sensitive sodium channels in rat skeletal muscle fibres

1998 ◽  
Vol 1373 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Jean-François Desaphy ◽  
Annamaria De Luca ◽  
Paola Imbrici ◽  
Diana Conte Camerino
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Muscle Fibres ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Fibres

Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers

1998 ◽  
Vol 275 (6) ◽  
pp. C1465-C1472 ◽  
Author(s):  
Jean-François Desaphy ◽  
Annamaria De Luca ◽  
Diana Conte Camerino
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Single Channel ◽  
Muscle Fibers ◽  
Rat Skeletal Muscle ◽  
Patch Clamp Technique ◽  
Cyclic Monophosphate ◽  
Adult Rat ◽  
Skeletal Muscle Fibers ◽  
Steady State Inactivation

Although the skeletal muscle sodium channel is a good substrate for cAMP-dependent protein kinase (PKA), no functional consequence was observed for this channel expressed in heterologous systems. Therefore, we investigated the effect of 8-(4-chlorophenylthio)adenosine 3′,5′-cyclic monophosphate (CPT-cAMP), a membrane-permeable cAMP analog, on the native sodium channels of freshly dissociated rat skeletal muscle fibers by means of the cell-attached patch-clamp technique. Externally applied CPT-cAMP (0.5 mM) reduced peak ensemble average currents by ∼75% with no change in kinetics. Single-channel conductance and normalized activation curves were unchanged by CPT-cAMP. In contrast, steady-state inactivation curves showed a reduction of the maximal available current and a negative shift of the half-inactivation potential. Similar effects were observed with dibutyryl adenosine 3′,5′-cyclic monophosphate but not with cAMP, which does not easily permeate the cell membrane. Incubation of fibers for 1 h with 10 μM H-89, a PKA inhibitor, did not prevent the effect of CPT-cAMP. Finally, the β-adrenoreceptor agonist isoproterenol mimicked CPT-cAMP when applied at 0.5 mM but had no effect at 0.1 mM. These results indicate that cAMP inhibits native skeletal muscle sodium channels by acting within the fiber, independently of PKA activation.

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