scholarly journals Minimal role of nitric oxide in basal coronary flow regulation and cardiac energetics of blood-perfused isolated canine heart.

1996 ◽  
Vol 491 (2) ◽  
pp. 455-463 ◽  
Author(s):  
A Saeki ◽  
F A Recchia ◽  
H Senzaki ◽  
D A Kass
Keyword(s):  
Nitric Oxide ◽  
Coronary Flow ◽  
Flow Regulation ◽  
Canine Heart ◽  
Cardiac Energetics ◽  
Coronary Flow Regulation

Central Neural Aspects of Coronary Flow Regulation

2020 ◽  
pp. 249-263
Author(s):  
D. D. Gutterman ◽  
A. C. Bonham ◽  
J. M. Arthur ◽  
J. E. Stuhlmuller ◽  
G. F. Gebhart ◽  
...  
Keyword(s):  
Coronary Flow ◽  
Flow Regulation ◽  
Coronary Flow Regulation

Nitric oxide modulates epicardial coronary basal vasomotor tone in awake dogs

1990 ◽  
Vol 258 (4) ◽  
pp. H1250-H1254 ◽  
Author(s):  
A. Chu ◽  
D. E. Chambers ◽  
C. C. Lin ◽  
W. D. Kuehl ◽  
F. R. Cobb
Keyword(s):  
Nitric Oxide ◽  
Coronary Flow ◽  
Diastolic Pressure ◽  
Coronary Vessels ◽  
Aortic Pressure ◽  
Left Ventricular ◽  
Vasomotor Tone ◽  
Coronary Vasomotor Tone ◽  
Endogenous Nitric Oxide

This study evaluates the role of endogenous nitric oxide in the modulation of basal coronary vasomotor tone by studying the effects of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide formation from L-arginine, on resting epicardial coronary diameter and coronary flow. L-NMMA (5 mg/kg) was infused in seven awake dogs chronically instrumented with coronary dimension crystals for measurement of epicardial coronary diameter, and Doppler flow probes for quantitation of phasic coronary flow (vasomotion of distal regulatory resistance coronary vessels). Epicardial coronary diameter decreased 5.5% from 3.47 +/- 0.17 to 3.28 +/- 0.15 mm (mean +/- SE). The diameter change was gradual, reaching a maximum at 13 +/- 2 min after infusion, and persistent, lasting greater than 90 min. Phasic coronary flow did not change. Mean aortic pressure significantly increased from 99 +/- 3 to 111 +/- 3 mmHg and heart rate decreased from 56 +/- 4 to 46 +/- 3 beats/min. Left ventricular end-diastolic pressure and contractility were not significantly altered. L-Arginine (66 mg/kg) but not D-arginine reversed all hemodynamic parameters. These data support an important role of nitric oxide in modulating basal epicardial coronary vasomotor tone and systemic vascular resistance.

Coronary flow and oxidative stress during local anaphylactic reaction in isolated mice heart: the role of nitric oxide (NO)

2015 ◽  
Vol 412 (1-2) ◽  
pp. 221-227
Author(s):  
Vesna Milicic ◽  
Vladimir Zivkovic ◽  
Nevena Jeremic ◽  
Nebojsa Arsenijevic ◽  
Dragan Djuric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Anaphylactic Reaction ◽  
Coronary Flow ◽  
And Oxidative Stress
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