scholarly journals A novel inward-rectifying K+ current with a cell-cycle dependence governs the resting potential of mammalian neuroblastoma cells.

1995 ◽  
Vol 489 (2) ◽  
pp. 455-471 ◽  
Author(s):  
A Arcangeli ◽  
L Bianchi ◽  
A Becchetti ◽  
L Faravelli ◽  
M Coronnello ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Neuroblastoma Cells ◽  
Resting Potential ◽  
K Current ◽  
A Cell ◽  
Cell Cycle Dependence ◽  
Cycle Dependence

scholarly journals Distinct localization and cell cycle dependence of COOH terminally tyrosinolated alpha-tubulin in the microtubules of Trypanosoma brucei brucei.

1987 ◽  
Vol 104 (3) ◽  
pp. 439-446 ◽  
Author(s):  
T Sherwin ◽  
A Schneider ◽  
R Sasse ◽  
T Seebeck ◽  
K Gull
Keyword(s):  
Cell Cycle ◽  
Trypanosoma Brucei ◽  
Temporal Modulation ◽  
Trypanosoma Brucei Brucei ◽  
Alpha Tubulin ◽  
Tubulin Isoforms ◽  
A Cell ◽  
Cell Cycle Dependence ◽  
Microtubular Structures ◽  
Cycle Dependence

alpha-Tubulin can be posttranslationally modified in that its COOH-terminal amino acid residue, tyrosine, can be selectively removed and replaced again. This reaction cycle involves two enzymes, tubulin carboxypeptidase and tubulin tyrosine ligase. The functional significance of this unusual modification is unclear. The present study demonstrates that posttranslational tyrosinolation of alpha-tubulin does occur in the parasitic hemoflagellate Trypanosoma brucei brucei and that posttranslational tyrosinolation can be detected in both alpha-tubulin isoforms found in this organism. Trypanosomes contain a number of microtubular structures: the flagellar axoneme; the subpellicular layer of singlet microtubules which are closely associated with the cell membrane; the basal bodies; and a cytoplasmic pool of soluble tubulin. Tyrosinolated alpha-tubulin is present in all these populations. However, immunofluorescence studies demonstrate a distinct localization of tyrosinolated alpha-tubulin within individual microtubules and organelles. This localization is subject to a temporal modulation that correlates strongly with progress of a cell through the cell cycle. Our results indicate that the presence of tyrosinolated alpha-tubulin is a marker for newly formed microtubules.

Cell cycle dependence of inositol phosphate levels in neuroblastoma cells

1988 ◽  
Vol 255 (4) ◽  
pp. C531-C535 ◽  
Author(s):  
L. F. Fleischman ◽  
L. Cantley
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Inositol Phosphates ◽  
Inositol Phosphate ◽  
Neuroblastoma Cells ◽  
Cycle Progression ◽  
Inositol Phosphate Production ◽  
Early Peak ◽  
Cell Cycle Dependence ◽  
Cycle Dependence

To investigate the timing of inositol lipid turnover in relation to the cell cycle, inositol phosphates and lipids were measured in neuroblastoma (Neuro-2A) cells that were prelabeled with [3H]inositol and synchronized by a mitotic shakeoff technique. Distinct early and late phases of inositol phosphate production were identified. The early peak occurs between the 2nd and 4th hour after mitosis near the G1/S transition. A later peak occurs around the peak of S phase (DNA synthesis) at 7-8 h after mitosis. These findings suggest that activation of phosphatidylinositol turnover generates signals that play a role in cell cycle progression.

The Cell Cycle Dependence of Thermotolerance: II. CHO Cells Heated at 45.0°C

1984 ◽  
Vol 98 (3) ◽  
pp. 491 ◽  
Author(s):  
R. A. Read ◽  
M. H. Fox ◽  
J. S. Bedford
Keyword(s):  
Cell Cycle ◽  
Cho Cells ◽  
Cell Cycle Dependence ◽  
Cycle Dependence

scholarly journals Cell Cycle-Dependence of Autophagic Activity and Inhibition of Autophagosome Formation at M Phase in Tobacco BY-2 Cells

2020 ◽  
Vol 21 (23) ◽  
pp. 9166
Author(s):  
Shigeru Hanamata ◽  
Takamitsu Kurusu ◽  
Kazuyuki Kuchitsu
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Plant Cells ◽  
Regulatory Mechanisms ◽  
Cdk Inhibitor ◽  
Autophagosome Formation ◽  
Cycle Progression ◽  
M Phase ◽  
Cell Cycle Dependence ◽  
Cycle Dependence

Autophagy is ubiquitous in eukaryotic cells and plays an essential role in stress adaptation and development by recycling nutrients and maintaining cellular homeostasis. However, the dynamics and regulatory mechanisms of autophagosome formation during the cell cycle in plant cells remain poorly elucidated. We here analyzed the number of autophagosomes during cell cycle progression in synchronized tobacco BY-2 cells expressing YFP-NtATG8a as a marker for the autophagosomes. Autophagosomes were abundant in the G2 and G1 phases of interphase, though they were much less abundant in the M and S phases. Autophagosomes drastically decreased during the G2/M transition, and the CDK inhibitor roscovitine inhibited the G2/M transition and the decrease in autophagosomes. Autophagosomes were rapidly increased by a proteasome inhibitor, MG-132. MG-132-induced autophagosome formation was also markedly lower in the M phases than during interphase. These results indicate that the activity of autophagosome formation is differently regulated at each cell cycle stage, which is strongly suppressed during mitosis.

scholarly journals Cell Cycle Dependence of Group VIA Calcium-independent Phospholipase A2Activity

2004 ◽  
Vol 279 (51) ◽  
pp. 52881-52892 ◽  
Author(s):  
Alex D. Manguikian ◽  
Suzanne E. Barbour
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Dependence ◽  
Cycle Dependence

scholarly journals Middle‐Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms

PROTEOMICS ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 1700442 ◽  
Author(s):  
Tingting Jiang ◽  
Michael E. Hoover ◽  
Matthew V. Holt ◽  
Michael A. Freitas ◽  
Alan G. Marshall ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Posttranslational Modifications ◽  
Histone H4 ◽  
Cell Cycle Dependence ◽  
Cycle Dependence
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