scholarly journals Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size.

1992 ◽  
Vol 445 (1) ◽  
pp. 639-658 ◽  
Author(s):  
R S Scroggs ◽  
A P Fox
Keyword(s):  
Dorsal Root Ganglion ◽  
Calcium Current ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Adult Rat ◽  
Current Variation ◽  
Ganglion Neurons

scholarly journals Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity

1994 ◽  
Vol 72 (6) ◽  
pp. 2796-2815 ◽  
Author(s):  
M. A. Rizzo ◽  
J. D. Kocsis ◽  
S. G. Waxman
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Half Time ◽  
Drg Neurons ◽  
Patch Clamp Technique ◽  
Adult Rat ◽  
Voltage Dependent ◽  
Order Of Magnitude ◽  
Ganglion Neurons

1. Voltage-dependent Na+ conductances were studied in small (18-25 microns diam) adult rat dorsal root ganglion (DRG) neurons with the use of the whole cell patch-clamp technique. Na+ currents were also recorded from larger (44-50 microns diam) neurons and compared with those of the small neurons. 2. The predominant Na+ conductance in the small neurons was selective over tetramethylammonium by at least 10-fold and was resistant to 1 microM external tetrodotoxin (TTX). Na+ conductances in many larger DRG neurons were kinetically faster and, in contrast, were blocked by 1 microM TTX. 3. The Na+ conductance in the small neurons was kinetically slow. Activation half-times were voltage dependent and ranged from 2 ms at -20 mV to 0.7 ms at +50 mV. Approximately 50% of the activation half-time was comprised of an initial delay. Inactivation half-times were voltage dependent and ranged from 11 ms at -20 mV to 2 ms at +50 mV. 4. Peak slow Na+ conductances were near maximal with conditioning potentials negative to -120 mV and were significantly reduced or eliminated with conditioning potentials positive to -40 mV. The slow Na+ conductance increased gradually with test potentials extending from -40 to +40 mV. In some cells the conductance could be saturated at +10 mV. Peak conductance/voltage relationships, although stable in a given neuron, revealed marked variability among neurons, spanning > 20- and 50-mV domains for steady-state activation and inactivation (current availability), respectively. 5. Kinetics remained stable within a given neuron over the course of an experiment. However, considerable kinetic variation was exhibited from neuron to neuron, such that the half-times of activation and of inactivation spanned an order of magnitude. In all small neurons studied there appeared to be a singular kinetic component of the current, based on sensitivity to the conditioning potential, voltage dependence of activation, and inactivation half-time. 6. Unique closing properties were exhibited by Na+ channels of the small neurons. Hyperpolarization following a depolarization-induced fully inactivated state resulted in tail currents that appeared to be the consequence of reactivation of the slow Na+ conductance. Tail currents recorded at various times during a fixed level of depolarization revealed that the underlying channels accumulated into a volatile inactivated state over the course of the preceding depolarization.(ABSTRACT TRUNCATED AT 400 WORDS)

Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat

2004 ◽  
Vol 113 (1-2) ◽  
pp. 32-42 ◽  
Author(s):  
Rainer Viktor Haberberger ◽  
Nadia Bernardini ◽  
Michaela Kress ◽  
Petra Hartmann ◽  
Katrin Susanne Lips ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine ◽  
Adult Rat ◽  
Ganglion Neurons

Neurotrophic and neuroprotective properties of exendin-4 in adult rat dorsal root ganglion neurons: involvement of insulin and RhoA

2015 ◽  
Vol 144 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Masami Tsukamoto ◽  
Naoko Niimi ◽  
Kazunori Sango ◽  
Shizuka Takaku ◽  
Yasushi Kanazawa ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Adult Rat ◽  
Ganglion Neurons

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

2013 ◽  
Vol 62 (3) ◽  
pp. 330-339 ◽  
Author(s):  
Shizuka Takaku ◽  
Hiroko Yanagisawa ◽  
Kazuhiko Watabe ◽  
Hidenori Horie ◽  
Toshihiko Kadoya ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Neurite Outgrowth ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Pi3k Signaling ◽  
Adult Rat ◽  
Ganglion Neurons
Sign in / Sign up

Export Citation Format

Share Document