scholarly journals Changes in discharge rate of fusimotor neurones provoked by fatiguing contractions of cat triceps surae muscles.

1992 ◽  
Vol 445 (1) ◽  
pp. 499-513 ◽  
Author(s):  
M Ljubisavljević ◽  
K Jovanović ◽  
R Anastasijević
Keyword(s):  
Discharge Rate ◽  
Triceps Surae ◽  
Triceps Surae Muscles ◽  
Fusimotor Neurones ◽  
Fatiguing Contractions

Changes in discharge rate of cat hamstring fusimotor neurones during fatiguing contractions of triceps surae muscles

1992 ◽  
Vol 579 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Milosˇ Ljubisavljević ◽  
Ksenija Jovanović ◽  
Radmila Anastasijević
Keyword(s):  
Discharge Rate ◽  
Triceps Surae ◽  
Triceps Surae Muscles ◽  
Fusimotor Neurones ◽  
Fatiguing Contractions

Beta-contributions to fusimotor action in triceps surae muscles of decerebrated cats

1987 ◽  
Vol 57 (2) ◽  
pp. 574-595 ◽  
Author(s):  
S. E. Grill ◽  
W. Z. Rymer
Keyword(s):  
Muscle Force ◽  
Discharge Rate ◽  
Muscle Spindles ◽  
Triceps Surae ◽  
Medial Gastrocnemius ◽  
Gamma Activity ◽  
Response Patterns ◽  
Two Measures ◽  
Triceps Surae Muscles ◽  
Stimulation Of

The discharge of spindle afferents from medial gastrocnemius and soleus muscles was recorded in the decerebrated cat preparation, under isometric conditions and during ramp and hold stretches. Motor output was varied systematically by manual stimulation of the contralateral hindlimb. Twenty-six of 34 afferents showed response patterns consistent with enhancement of dynamic and/or static fusimotor input with increasing muscle force. To establish whether force-related fusimotor effects were mediated at least partly by beta-input, beta-innervation to these same spindles was sought, using a ventral root stimulation protocol. Twenty-three of the 34 afferents were shown to receive beta-innervation, which was most often static in type. For two measures of fusimotor action, the slope of the afferent dynamic rate-length relation and the discharge rate measured during the last portion of ramp stretch, significant increases in the measure, which paralleled increases in muscle force, made it statistically more likely that the afferent received beta-innervation. Our measures did not successfully predict the type of beta-input (beta-static or beta-dynamic). Procaine block of gamma-fibers produced substantial reductions in fusimotor effect in seven spindle afferents (although modest residual fusimotor effects were detectable for 3/7 afferents). The severity of these reductions indicates that beta-action probably requires concurrent gamma-input to the spindle in order to be effective. In support of this possibility, the fusimotor effects of electrical stimulation of single beta-fibers were greatly reduced for five out of six afferents during procaine block of gamma-fibers, compared with the beta-effects recorded when modest levels of spontaneous gamma-activity were present. We conclude that beta-innervation to muscle spindles of triceps surae is common and that this innervation exerts significant fusimotor effects. It appears likely that beta-motoneurons are able to produce both static and dynamic effects above extrafusal threshold, but that the actions require on-going gamma-activity in order to be effective.

Effects of hypoxia on the discharge of group III and IV muscle afferents in cats

1992 ◽  
Vol 73 (6) ◽  
pp. 2524-2529 ◽  
Author(s):  
J. M. Hill ◽  
J. G. Pickar ◽  
M. D. Parrish ◽  
M. P. Kaufman
Keyword(s):  
Blood Supply ◽  
Discharge Rate ◽  
Pressor Response ◽  
Supply And Demand ◽  
Venous Blood ◽  
Group Iv ◽  
Triceps Surae ◽  
Group Iii ◽  
Triceps Surae Muscles ◽  
Sensitive Group

The reflex pressor response evoked by static muscular contraction is widely believed to be caused by the stimulation of group III and IV afferents. Although the specific nature of the contraction-induced stimulus to these thin-fiber afferents is unknown, they are thought to be stimulated in part by a condition arising from a mismatch between blood supply and demand in the exercising muscle. Hypoxia, a condition found in skeletal muscle during such a mismatch, may stimulate these afferents. We have therefore tested the hypothesis that perfusion of the triceps surae muscles with hypoxic blood stimulates group III and IV afferents in barbiturate-anesthetized cats. We found that 3–3.5 min of hypoxia with the triceps surae muscles at rest significantly (P < 0.05) increased the average discharge rate of contraction-sensitive group IV afferents but had no effect on the average discharge rate of contraction-sensitive group III afferents. Hypoxia had only trivial effects on the discharge of contraction-insensitive group III and IV afferents. Hypoxia stimulated 4 of 11 contraction-sensitive group IV afferents and 2 of 13 contraction-sensitive group III afferents. The responses of the afferents stimulated by hypoxia were small in magnitude. Hypoxia with the muscles at rest appeared to have no effect on either hydrogen or lactate ion concentrations in the femoral venous blood. In addition, hypoxia increased the responses to contraction in only 3 of 22 group III and 4 of 21 group IV afferents tested. We conclude that muscle tissue hypoxia is a minor stimulus to afferents that sense a mismatch between blood supply and demand during static contraction.

Muscular contraction stimulates posterior hypothalamic neurons

1989 ◽  
Vol 256 (2) ◽  
pp. R348-R356 ◽  
Author(s):  
T. G. Waldrop ◽  
R. W. Stremel
Keyword(s):  
Discharge Rate ◽  
Muscular Contraction ◽  
Posterior Hypothalamus ◽  
Triceps Surae ◽  
Discharge Frequency ◽  
Hypothalamic Region ◽  
Cardiorespiratory Responses ◽  
Hindlimb Muscles ◽  
Rhythmic Contractions ◽  
Triceps Surae Muscles

Recent studies have suggested that the subthalamic locomotor region (STLR) of the posterior hypothalamus is involved in modulating cardiorespiratory responses to feedback from contracting muscles. The purpose of this study was to determine whether neurons in this hypothalamic region alter their discharge frequency during contraction of hindlimb muscles. Stainless steel electrodes were used to record single-unit activity of STLR neurons during static and rhythmic contractions of hindlimb muscles in anesthetized cats. Recordings were also made from neurons in areas outside but surrounding the subthalamic locomotor region. Contraction of the triceps surae muscles was induced by stimulation of the peripheral cut ends of the L7 and S1 ventral roots. Both static and rhythmic contractions of the triceps surae evoked an increase in the discharge rate of the majority of the STLR cells studied. Two types of excitatory responses were observed: 1) abrupt increases in discharge frequency at the onset of muscular contraction and 2) a delayed more gradual increase in firing. Most of the cells that responded to muscular contraction could be activated by mechanical probing of the triceps surae muscles. However, the changes in discharge frequency were unrelated to changes in arterial pressure occurring during muscular contraction. Most of the neurons located outside the STLR were slightly inhibited by or did not respond to muscular contraction. Thus input from contracting muscles exerts predominantly an excitatory effect on neurons in the posterior hypothalamus. These results are consistent with other studies which have concluded that this hypothalamic site is involved in influencing the cardiorespiratory responses to muscular contraction.

Dynamic Force Responses in Electrically Stimulated Triceps Surae Muscles: Effects of Fatigue and Temperature

1999 ◽  
Vol 23 (5) ◽  
pp. 436-439 ◽  
Author(s):  
Dietmar Rafolt ◽  
Eugen Gallasch ◽  
Winfried Mayr ◽  
Hermann Lanmuller
Keyword(s):  
Triceps Surae ◽  
Dynamic Force ◽  
Triceps Surae Muscles

Receptor Mechanisms Underlying Heterogenic Reflexes Among the Triceps Surae Muscles of the Cat

1999 ◽  
Vol 81 (2) ◽  
pp. 467-478 ◽  
Author(s):  
T. Richard Nichols
Keyword(s):  
Triceps Surae ◽  
Spinal Reflex ◽  
Medial Gastrocnemius ◽  
Entire Group ◽  
Passive Components ◽  
Mechanical Coupling ◽  
Golgi Tendon Organs ◽  
Reflex Pathways ◽  
Tendon Organs ◽  
Triceps Surae Muscles

Receptor mechanisms underlying heterogenic reflexes among the triceps surae muscles of the cat. The soleus (S), medial gastrocnemius (MG), and lateral gastrocnemius (LG) muscles of the cat are interlinked by rapid spinal reflex pathways. In the decerebrate state, these heterogenic reflexes are either excitatory and length dependent or inhibitory and force dependent. Mechanographic analysis was used to obtain additional evidence that the muscle spindle primary ending and the Golgi tendon organ provide the major contributions to these reflexes, respectively. The tendons of the triceps surae muscles were separated and connected to independent force transducers and servo-controlled torque motors in unanesthetized, decerebrate cats. The muscles were activated as a group using crossed-extension reflexes. Electrical stimulation of the caudal cutaneous sural nerve was used to provide a particularly strong activation of MG and decouple the forces of the triceps surae muscles. During either form of activation, the muscles were stretched either individually or in various combinations to determine the strength and characteristics of autogenic and heterogenic feedback. The corresponding force responses, including both active and passive components, were measured during the changing background tension. During activation of the entire group, the excitatory, heterogenic feedback linking the three muscles was found to be strongest onto LG and weakest onto MG, in agreement with previous results concerning the strengths of heteronymous Ia excitatory postsynaptic potentials among the triceps surae muscles. The inhibition, which is known to affect only the soleus muscle, was dependent on active contractile force and was detected essentially as rapidly as length dependent excitation. The inhibition outlasted the excitation and was blocked by intravenous strychnine. These results indicate that the excitatory and inhibitory effects are dominated by feedback from primary spindle receptors and Golgi tendon organs. The interactions between these two feedback pathways potentially can influence both the mechanical coupling between ankle and knee.

Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

2002 ◽  
Vol 92 (4) ◽  
pp. 1635-1641 ◽  
Author(s):  
Shawn G. Hayes ◽  
Nicolas B. Moya Del Pino ◽  
Marc P. Kaufman
Keyword(s):  
Triceps Surae ◽  
Central Command ◽  
Neuronal Function ◽  
Ventilatory Responses ◽  
Exercise Pressor Reflex ◽  
Arterial Blood ◽  
Static Contraction ◽  
17Β Estradiol ◽  
Pressor Reflex ◽  
Triceps Surae Muscles

Static exercise is well known to increase heart rate, arterial blood pressure, and ventilation. These increases appear to be less in women than in men, a difference that has been attributed to an effect of estrogen on neuronal function. In decerebrate male cats, we examined the effect of estrogen (17β-estradiol; 0.001, 0.01, 0.1, and 1.0 μg/kg iv) on the cardiovascular and ventilatory responses to central command and the exercise pressor reflex, the two neural mechanisms responsible for evoking the autonomic and ventilatory responses to exercise. We found that 17β-estradiol, in each of the three doses tested, attenuated the pressor, cardioaccelerator, and phrenic nerve responses to electrical stimulation of the mesencephalic locomotor region (i.e., central command). In contrast, none of the doses of 17β-estradiol had any effect on the pressor, cardioaccelerator, and ventilatory responses to static contraction or stretch of the triceps surae muscles. We conclude that, in decerebrate male cats, estrogen injected intravenously attenuates cardiovascular and ventilatory responses to central command but has no effect on responses to the exercise pressor reflex.

Production of hydroxyl radicals in contracting skeletal muscle of cats

1996 ◽  
Vol 81 (3) ◽  
pp. 1197-1206 ◽  
Author(s):  
C. A. O'Neill ◽  
C. L. Stebbins ◽  
S. Bonigut ◽  
B. Halliwell ◽  
J. C. Longhurst
Keyword(s):  
Skeletal Muscle ◽  
Triceps Surae ◽  
Oxygen Species ◽  
Static Contraction ◽  
Maximal Tension ◽  
Cumulative Production ◽  
Triceps Surae Muscles ◽  
Specific Species

Reactive oxygen species increase during exhaustive contraction of skeletal muscle, but characterization of the specific species involved and their rates of production during nonexhaustive muscle contraction have not been investigated. We hypothesized that the production rate of hydroxyl radical (.OH) increases in contracting muscle and that this rate is attenuated by pretreatment with deferoxamine (Def) or dimethylthiourea (DMTU). We measured the rate of production of .OH before, during, and after 5 min of intermittent static contraction of the triceps surae muscles in cats (n = 6) using the formation of p-, m-, and o-tyrosines by hydroxylation of phenylalanine. L-Phenylalanine (30 mg/kg i.v.) was administered to each animal 3 min before contraction. Blood samples were collected from the popliteal vein 1 min before contraction; 1, 3, and 4.5 min during contraction; and 1 min after contraction. During and after contraction, the cumulative production rates of p-, m-, and o-tyrosines were elevated by 42.84 +/- 5.41, 0.25 +/- 0.04, and 0.21 +/- 0.03 nmol.min-1.g-1, respectively, compared with noncontracting triceps surae muscles. Pretreatment with Def (10 mg/kg i.v.; n = 5) or DMTU (10 mg/kg i.v.; n = 4) decreased the cumulative rates of production of p-, m-, and o-tyrosines during and after contraction. Additionally, the rate of tyrosine production increased in proportion to the percentage of maximal tension developed by the triceps surae muscles. These results directly demonstrate that .OH is produced in vivo in the skeletal muscle of cats during intermittent static contraction and that production can occur before the onset of fatigue.

Gadolinium attenuates exercise pressor reflex in cats

2001 ◽  
Vol 280 (5) ◽  
pp. H2153-H2161 ◽  
Author(s):  
Shawn G. Hayes ◽  
Marc P. Kaufman
Keyword(s):  
Pressor Response ◽  
Oxygen Demand ◽  
Muscle Afferents ◽  
Triceps Surae ◽  
Mechanical Stimuli ◽  
Group Iii ◽  
Exercise Pressor Reflex ◽  
Static Contraction ◽  
Pressor Reflex ◽  
Triceps Surae Muscles

The exercise pressor reflex, which arises from the contraction-induced stimulation of group III and IV muscle afferents, is widely believed to be evoked by metabolic stimuli signaling a mismatch between blood/oxygen demand and supply in the working muscles. Nevertheless, mechanical stimuli may also play a role in evoking the exercise pressor reflex. To determine this role, we examined the effect of gadolinium, which blocks mechanosensitive channels, on the exercise pressor reflex in both decerebrate and α-chloralose-anesthetized cats. We found that gadolinium (10 mM; 1 ml) injected into the femoral artery significantly attenuated the reflex pressor responses to static contraction of the triceps surae muscles and to stretch of the calcaneal (Achilles) tendon. In contrast, gadolinium had no effect on the reflex pressor response to femoral arterial injection of capsaicin (5 μg). In addition, gadolinium significantly attenuated the responses of group III muscle afferents, many of which are mechanically sensitive, to both static contraction and to tendon stretch. Gadolinium, however, had no effect on the responses of group IV muscle afferents, many of which are metabolically sensitive, to either static contraction or to capsaicin injection. We conclude that mechanical stimuli arising in contracting skeletal muscles contribute to the elicitation of the exercise pressor reflex.

Effective synaptic current can be estimated from measurements of neuronal discharge

1992 ◽  
Vol 68 (3) ◽  
pp. 964-968 ◽  
Author(s):  
R. K. Powers ◽  
F. R. Robinson ◽  
M. A. Konodi ◽  
M. D. Binder
Keyword(s):  
Steady State ◽  
Synaptic Input ◽  
Discharge Rate ◽  
Triceps Surae ◽  
Repetitive Firing ◽  
Basic Question ◽  
Detailed Knowledge ◽  
Synaptic Efficacy ◽  
Synaptic Current ◽  
Discharge Rates

1. The basic question of how motoneurons transform synaptic inputs into spike train outputs remains unresolved, despite detailed knowledge of their morphology, electrophysiology, and synaptic connectivity. We have approached this problem by making measurements of a synaptic input under steady-state conditions and combining them with quantitative assessments of their effects on the discharge rates of cat spinal motoneurons. 2. We used a modified voltage-clamp technique to measure the steady-state effective synaptic currents (IN) produced by rubrospinal input to cat triceps surae motoneurons. In the same motoneurons we measured the slope of the firing rate-injected current (f-i) relation in the primary range. We then reactivated the rubrospinal input during steady, repetitive firing to assess its effect on motoneuron discharge rate. 3. We found that changes in the steady-state discharge rate of a motoneuron produced by this synaptic input could be described simply as the product of the net effective synaptic current measured at the soma and the slope of the motoneuron's f-i relation. This expression essentially redefines synaptic efficacy in terms of a cell's basic input-output function. Further, measurements of effective synaptic current simplify the task of estimating synaptic efficacy, because detailed knowledge of neither the electrotonic architecture of the postsynaptic cell nor of the locations of the presynaptic boutons is required.

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