scholarly journals Synaptic excitation of inhibitory cells by single CA3 hippocampal pyramidal cells of the guinea-pig in vitro.

1990 ◽  
Vol 428 (1) ◽  
pp. 61-77 ◽  
Author(s):  
R Miles
Keyword(s):  
Guinea Pig ◽  
Pyramidal Cells ◽  
Synaptic Excitation ◽  
Hippocampal Pyramidal Cells

Different Effects of Gabaergic Anticonvulsants on 4-Aminopyridine-Induced Spontaneous Gabaergic Hyperpolarizations of Hippocampal Pyramidal Cells—Implication for their Potency in Migraine Therapy

Cephalalgia ◽  
2000 ◽  
Vol 20 (6) ◽  
pp. 533-537 ◽  
Author(s):  
T Leniger ◽  
M Wiemann ◽  
D Bingmann ◽  
A Hufnagel ◽  
U Bonnet
Keyword(s):  
Clinical Studies ◽  
Pyramidal Cells ◽  
Intracellular Recordings ◽  
Migraine Therapy ◽  
Potential Fluctuations ◽  
Acting Agent ◽  
Fast Acting ◽  
Membrane Potential Fluctuations ◽  
Hippocampal Pyramidal Cells

Clinical studies indicate anti-migraneous efficacy of the probably GABAergic anti-convulsants valproate and gabapentin. For the GABAergic anticonvulsants vigabatrin and tiagabine, studies about antimigraneous efficacy are missing. The aim of this study was to test the GABAergic potency of these drugs in vitro before further clinical studies. Intracellular recordings were obtained from hippocampal pyramidal cells. Spontaneous GABAergic hyperpolarizations (SGH) elicited by 75 μ m 4-aminopyridine were used to test the effect of these drugs on GABA-dependent potentials. Tiagabine (0.1 m m) prolonged the duration of SGH. Furthermore, monophasic SGH turned over into triphasic typical GABAergic membrane potential fluctuations within 20 min. In contrast, valproate, gabapentin, and vigabatrin failed to affect SGH up to 60 min of application. The reason for the fast action of tiagabine on SGH may be caused by a faster increase of synaptic GABA levels compared with other drugs. As migraine therapy benefits from an augmentation of GABA activity, we recommend clinical studies of tiagabine as a fast-acting agent in migraine attacks.

Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro

1981 ◽  
Vol 221 (2) ◽  
pp. 402-408 ◽  
Author(s):  
Q.J. Pittman ◽  
G.R. Siggins
Keyword(s):  
Pyramidal Cells ◽  
Hippocampal Pyramidal Cells
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