scholarly journals A comparison of head-down tilt with low-dose infusion of atrial natriuretic peptide in man.

1989 ◽  
Vol 410 (1) ◽  
pp. 341-350 ◽  
Author(s):  
M J Allen ◽  
V T Ang ◽  
D Bennett
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Low Dose ◽  
Dose Infusion ◽  
Atrial Natriuretic

Low dose infusion of atrial natriuretic peptide causes salt and water excretion in normal man

1988 ◽  
Vol 74 (4) ◽  
pp. 359-363 ◽  
Author(s):  
Alyn Morice ◽  
Joanna Pepke-Zaba ◽  
Elena Loysen ◽  
Ruth Lapworth ◽  
Michael Ashby ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Sodium Excretion ◽  
Low Dose ◽  
Volume Index ◽  
Urinary Volume ◽  
Dose Infusion ◽  
Atrial Natriuretic

1. The effects of low dose infusion of atrial natriuretic peptide (ANP) were observed in a double-blind, placebo-controlled study in six fluid-loaded volunteers. After baseline observations, hourly increments of 0.4, 2 and 10 pmol min−1 kg−1 were infused with continuous observation of heart rate, blood pressure and cardiac output. Plasma ANP, aldosterone, and catecholamines, and urinary volume and sodium excretion, were estimated at half-hourly intervals. 2. ANP infusion resulted in an increase of 35, 98 and 207% in urinary sodium excretion and of 10, 20 and 71% in urinary volume when compared with placebo. Plasma ANP was markedly elevated above placebo levels only during infusion of 10 pmol of ANP min−1 kg−1. 3. No change in heart rate or blood pressure was noted during the study, but a significant fall in stroke volume index was observed during active treatment. Plasma levels of aldosterone and catecholamines were not significantly different on the 2 treatment days. 4. The potent natriuretic and diuretic effects of this peptide at plasma concentrations not significantly elevated from physiological suggest a hormonal role for ANP in the homoeostasis of salt and water balance.

Low-Dose Brain Natriuretic Peptide Infusion in Normal Men and the Influence of Endopeptidase Inhibition

1997 ◽  
Vol 92 (3) ◽  
pp. 255-260 ◽  
Author(s):  
C. M. Florkowski ◽  
A. M. Richards ◽  
E. A. Espiner ◽  
T. G. Yandle ◽  
E. Sybertz ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Plasma Renin Activity ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Low Dose ◽  
Plasma Renin ◽  
Renin Activity ◽  
Plasma Brain Natriuretic Peptide ◽  
Normal Men ◽  
Atrial Natriuretic

1. To assess the threshold dose for bioactivity of brain natriuretic peptide and the role of endopeptidase 24.11 in metabolism of brain natriuretic peptide at physiological plasma levels, we studied eight normal men receiving 2 h infusions of low-dose brain natriuretic peptide [0.25 and 0.5 pmol min−1 kg−1 with and without pretreatment with an endopeptidase inhibitor (SCH 32615, 250 mg intravenously)] in placebo-controlled studies. 2. Plasma brain natriuretic peptide increased 2-fold during the infusion of 0.25 pmol min−1 kg−1 (mean increment above control 3.9 pmol/l, P < 0.001), and tripled (P < 0.001) with 0.5 pmol min−1 kg−1. Plasma renin activity was inhibited by both doses (14.8%, P < 0.01, and 20%, P < 0.001, respectively). A significant natriuresis (56% increase in urine sodium/creatinine ratio, P < 0.02) occurred with the higher dose. Blood pressure, haematocrit, plasma cGMP, atrial natriuretic peptide and aldosterone were unaffected by either dose. 3. Compared with brain natriuretic peptide (0.5 pmol min−1 kg−1) alone, SCH 32615 pretreatment increased peak plasma brain natriuretic peptide (13.4±0.78 versus 12.4±0.86 pmol/l, P < 0.05), ANP (7.5±0.96 versus 5.9±0.4 pmol/l, P < 0.01) and cGMP (4.8 ± 1.7 versus 3.9 ± 1.4 nmol/l, P < 0.001). Plasma renin activity was further suppressed with SCH 32615 pretreatment (29% compared with 20%, P < 0.001). 4. Small acute increments in plasma brain natriuretic peptide (4 pmol/l) have significant biological effects in normal men without altering plasma atrial natriuretic peptide or cGMP.

Low-dose continuous infusion of human atrial natriuretic peptide during and after cardiac surgery

2000 ◽  
Vol 69 (3) ◽  
pp. 732-738 ◽  
Author(s):  
Akira Sezai ◽  
Motomi Shiono ◽  
Yukihiko Orime ◽  
Hiroaki Hata ◽  
Mitsumasa Hata ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Atrial Natriuretic Peptide ◽  
Continuous Infusion ◽  
Natriuretic Peptide ◽  
Low Dose ◽  
Human Atrial Natriuretic Peptide ◽  
Atrial Natriuretic

scholarly journals Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis

Critical Care ◽  
2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Hiroyuki Yamada ◽  
Kent Doi ◽  
Tatsuo Tsukamoto ◽  
Hideyasu Kiyomoto ◽  
Kazuto Yamashita ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Low Dose ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Atrial Natriuretic

Renal response of anesthetized rats to low-dose infusion of atrial natriuretic peptide

1988 ◽  
Vol 255 (3) ◽  
pp. R449-R455 ◽  
Author(s):  
H. Soejima ◽  
R. J. Grekin ◽  
J. P. Briggs ◽  
J. Schnermann
Keyword(s):  
Glomerular Filtration Rate ◽  
Atrial Natriuretic Peptide ◽  
Glomerular Filtration ◽  
Natriuretic Peptide ◽  
Filtration Rate ◽  
Arterial Blood ◽  
Dose Infusion ◽  
Physiological Interventions ◽  
Measurable Change ◽  
Atrial Natriuretic

Studies were performed in rats to determine the minimum infusion rate of atrial natriuretic peptide (ANP) associated with detectable changes in renal function and to determine the change in plasma levels of the peptide produced by these infusion rates. Synthetic ANP-(4-28) was administered to anesthetized euvolemic rats at rates ranging between 10 and 230 ng.kg-1.min-1 for 30 min. Significant natriuresis and diuresis were seen with an infusion of 20 ng.kg-1.min-1. At this rate of infusion, plasma ANP averaged 279 +/- 19.9 pmol/l (vs. 158 +/- 11.8 pmol/l in control rats). A transient increase in K excretion was seen with infusions higher than 100 ng.kg-1.min-1. There was no measurable change in glomerular filtration rate up to an infusion of 160 ng.kg-1.min-1. A significant decrease in mean arterial pressure was only seen with an infusion of 230 ng.kg-1.min-1. In volume-expanded rats, infusion of ANP at 10 ng.kg-1.min-1 induced a significant natriuresis. Our results indicate that natriuresis and diuresis are caused by an infusion of ANP which produces changes in plasma ANP concentration that may well result from stimulation of endogenous ANP release. In contrast, changes in K excretion, glomerular filtration rate, and arterial blood pressure may require changes in plasma ANP that are not easily achievable by physiological interventions.

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