scholarly journals The half-life of endothelium-derived relaxing factor released from bovine aortic endothelial cells in culture.

1987 ◽  
Vol 388 (1) ◽  
pp. 71-81 ◽  
Author(s):  
J A Angus ◽  
T M Cocks
1994 ◽  
Vol 106 (1) ◽  
pp. 75-81 ◽  
Author(s):  
P. Briffeuil ◽  
R. Thibaut-Vercruyssen ◽  
M.-F. Ronveaux-Dupal

1992 ◽  
Vol 281 (2) ◽  
pp. 297-300 ◽  
Author(s):  
K Schmidt ◽  
E R Werner ◽  
B Mayer ◽  
H Wachter ◽  
W R Kukovetz

Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.


Planta Medica ◽  
1990 ◽  
Vol 56 (04) ◽  
pp. 353-356 ◽  
Author(s):  
Toshiyuki Kaji ◽  
Nsimba Miezi ◽  
Kayoko Kaga ◽  
Naoka Ejiri ◽  
Nobuo Sakuragawa

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