scholarly journals Inward rectification and low threshold calcium conductance in rat cerebellar Purkinje cells. An in vitro study.

1986 ◽  
Vol 372 (1) ◽  
pp. 1-23 ◽  
Author(s):  
F Crepel ◽  
J Penit-Soria
Keyword(s):  
Purkinje Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Inward Rectification ◽  
Calcium Conductance ◽  
Low Threshold ◽  
Cerebellar Purkinje Cells

K+ channel activation and low-threshold Ca2+ spike of rat cerebellar Purkinje cells in vitro

Neuroreport ◽  
2003 ◽  
Vol 14 (2) ◽  
pp. 167-171 ◽  
Author(s):  
Pauline Cavelier ◽  
Thomas Desplantez ◽  
Huguette Beekenkamp ◽  
Jean-Louis Bossu
Keyword(s):  
Purkinje Cells ◽  
K Channel ◽  
Channel Activation ◽  
Low Threshold ◽  
Cerebellar Purkinje Cells

Development of ionic conductances in neurons of neurons of the inferior olive in the rat: an in vitro study

1988 ◽  
Vol 234 (1275) ◽  
pp. 199-218 ◽  
Keyword(s):  
Membrane Potential ◽  
Inferior Olive ◽  
Early Period ◽  
In Vitro Study ◽  
Inward Rectification ◽  
High Threshold ◽  
Ca Channel ◽  
Ionic Conductances ◽  
Low Threshold

Neurons of the inferior olive of the rat were studied at different stages of their postnatal (PN) development by using the current clamp technique in slices maintained in vitro . Antidromic and synaptic activation of inferior olivary neurons could be achieved in preparations as young as PN day 2. Neurons at this age already exhibited a variety of ionic conductances which included fast sodium-dependent spikes, high-threshold and low-threshold calcium spikes, potassium-dependent currents, Ca-dependent after-hyperpolarizing potentials (AHPS), and both instan­taneous and time-dependent inward rectification at hyperpolarized levels of membrane potential. The two types of Ca-dependent responses recorded in olivary neurons during the first postnatal week were graded with the magnitude of the depolarization imposed on the cells. Further­more, the high-threshold Ca spikes were only clearly observed during this early period when K conductances were depressed by the injection of caesium into the cells or by bath application of 4-aminopyridine. In contrast, the high-threshold Ca spikes could be obtained without sup­pression of K currents and were all-or-none in character in some neurons after PN day 8 and in all neurons after PN day 11. The observations suggest that the balance between K and Ca currents changes throughout maturation and is largely in favour of the K current until about the end of the first PN week. At all ages studied, the low-threshold Ca spikes were much less sensitive to the Ca channel blocker cadmium than were the high-threshold Ca spikes. Finally, spontaneous, regular oscillations of the membrane potential were observed for the first time at PN day 16 and were only commonly observed after PN day 19, suggesting a late develop­ment of electrotonic coupling between olivary neurons.

Phenylglycine derivatives antagonize the excitatory response of Purkinje cells to 1S,3R-ACPD: an in vivo and in vitro study

1993 ◽  
Vol 18 (3) ◽  
pp. 229-234 ◽  
Author(s):  
Kurt Lingenhöhl ◽  
Hans-Rudolf Olpe ◽  
Nafida Bendali ◽  
Thomas Knöpfel
Keyword(s):  
Purkinje Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Excitatory Response
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