scholarly journals Two types of calcium channels in the somatic membrane of new-born rat dorsal root ganglion neurones.

1985 ◽  
Vol 359 (1) ◽  
pp. 431-446 ◽  
Author(s):  
S A Fedulova ◽  
P G Kostyuk ◽  
N S Veselovsky
Keyword(s):  
Dorsal Root Ganglion ◽  
Calcium Channels ◽  
Dorsal Root ◽  
Somatic Membrane ◽  
New Born

G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons

1997 ◽  
Vol 762 (1-2) ◽  
pp. 235-239 ◽  
Author(s):  
Chao-Sheng Huang ◽  
Jin-Ho Song ◽  
Keiichi Nagata ◽  
Dennis Twombly ◽  
Jay Z Yeh ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Calcium Channels ◽  
G Proteins ◽  
High Voltage ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Ganglion Neurons

Voltage gated calcium channels in human dorsal root ganglion neurons

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jane E Hartung ◽  
Jamie K Moy ◽  
Emanuel Loeza-Alcocer ◽  
Vidhya Nagarajan ◽  
Ruth Jostock ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Calcium Channels ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Ganglion Neurons

scholarly journals IL-6 induced upregulation of T-type Ca2+ currents and sensitization of DRG nociceptors is attenuated by MNK inhibition

2020 ◽  
Vol 124 (1) ◽  
pp. 274-283
Author(s):  
Vivek Jeevakumar ◽  
Aysha Khalid Al Sardar ◽  
Farah Mohamed ◽  
Clay Matthew Smithhart ◽  
Theodore Price ◽  
...  
Keyword(s):  
Ion Channels ◽  
Dorsal Root Ganglion ◽  
Calcium Channels ◽  
Signaling Pathway ◽  
Membrane Trafficking ◽  
Dorsal Root ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Tumor Agent

In this study, we show that the MNK inhibitor and anti-tumor agent eFT508 (tomivosertib) is effective in attenuating IL-6 induced sensitization of dorsal root ganglion (DRG) nociceptors. Pretreatment with eFT508 in DRG cultures from mice helps mitigate the development of hyperexcitability in response to IL-6. Furthermore, our data reveal that the upregulation of T-type voltage-gated calcium channels following IL-6 application can be blocked by eFT508, implicating the MNK-eIF4E signaling pathway in membrane trafficking of ion channels.

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