scholarly journals Synaptic and antidromic potentials of visceral neurones in ganglia of the lumbar sympathetic chain of the cat.

1984 ◽  
Vol 350 (1) ◽  
pp. 413-428 ◽  
Author(s):  
D A Hartman ◽  
J Krier
Consultant ◽  
2020 ◽  
Vol 60 ◽  
Author(s):  
Michael Weipert ◽  
Sean O'Mara

2021 ◽  
Vol 19 ◽  
pp. 100295
Author(s):  
Monica H. Xing ◽  
Mykayla L. Sandler ◽  
R. Michael Tuttle ◽  
Azita Khorsandi ◽  
Shabnam Samankan ◽  
...  

2018 ◽  
Vol 28 (4) ◽  
pp. 829-834 ◽  
Author(s):  
A. Mahatthanatrakul ◽  
T. Itthipanichpong ◽  
C. Ratanakornphan ◽  
N. Numkarunarunrote ◽  
W. Singhatanadgige ◽  
...  

2018 ◽  
Vol 119 (2) ◽  
pp. 652-661 ◽  
Author(s):  
Siobhan C. Dongés ◽  
Jessica M. D’Amico ◽  
Jane E. Butler ◽  
Janet L. Taylor

Plasticity can be induced at human corticospinal-motoneuronal synapses by delivery of repeated, paired stimuli to corticospinal axons and motoneurons in a technique called paired corticospinal-motoneuronal stimulation (PCMS). To date, the mechanisms of the induced plasticity are unknown. To determine whether PCMS-induced plasticity is dependent on N-methyl-d-aspartate receptors (NMDARs), the effect of the noncompetitive NMDAR antagonist dextromethorphan on PCMS-induced facilitation was assessed in a 2-day, double-blind, placebo-controlled experiment. PCMS consisted of 100 pairs of stimuli, delivered at an interstimulus interval that produces facilitation at corticospinal-motoneuronal synapses that excite biceps brachii motoneurons. Transcranial magnetic stimulation elicited corticospinal volleys, which were timed to arrive at corticospinal-motoneuronal synapses just before antidromic potentials elicited in motoneurons with electrical brachial plexus stimulation. To measure changes in the corticospinal pathway at a spinal level, biceps responses to cervicomedullary stimulation (cervicomedullary motor evoked potentials, CMEPs) were measured before and for 30 min after PCMS. Individuals who displayed a ≥10% increase in CMEP size after PCMS on screening were eligible to take part in the 2-day experiment. After PCMS, there was a significant difference in CMEP area between placebo and dextromethorphan days ( P = 0.014). On the placebo day PCMS increased average CMEP areas to 127 ± 46% of baseline, whereas on the dextromethorphan day CMEP area was decreased to 86 ± 33% of baseline (mean ± SD; placebo: n = 11, dextromethorphan: n = 10). Therefore, dextromethorphan suppressed the facilitation of CMEPs after PCMS. This indicates that plasticity induced at synapses in the human spinal cord by PCMS may be dependent on NMDARs. NEW & NOTEWORTHY Paired corticospinal-motoneuronal stimulation can strengthen the synaptic connections between corticospinal axons and motoneurons at a spinal level in humans. The mechanism of the induced plasticity is unknown. In our 2-day, double-blind, placebo-controlled study we show that the N-methyl-d-aspartate receptor (NMDAR) antagonist dextromethorphan suppressed plasticity induced by paired corticospinal-motoneuronal stimulation, suggesting that an NMDAR-dependent mechanism is involved.


2014 ◽  
Vol 151 (1_suppl) ◽  
pp. P158-P158
Author(s):  
Gavin Setzen ◽  
Michael A. Keefe ◽  
Leighla H. Sharghi ◽  
Soojin Cho-Reyes ◽  
Benjamin A. Howie ◽  
...  

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