scholarly journals Visual cortical input alters spatial tuning in monkey lateral geniculate nucleus cells.

1984 ◽  
Vol 348 (1) ◽  
pp. 135-152 ◽  
Author(s):  
J W McClurkin ◽  
R T Marrocco
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Cortical Input ◽  
Lateral Geniculate ◽  
Spatial Tuning ◽  
Visual Cortical

Corticotectal circuit in the cat: a functional analysis of the lateral geniculate nucleus layers of origin

1988 ◽  
Vol 59 (6) ◽  
pp. 1783-1797 ◽  
Author(s):  
C. L. Colby
Keyword(s):  
Superior Colliculus ◽  
Lateral Geniculate Nucleus ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Visual Responses ◽  
Cortical Input ◽  
Cortical Areas ◽  
Lateral Geniculate ◽  
Contralateral Eye ◽  
Visual Cortical ◽  
Y Cells

1. The dorsal lateral geniculate nucleus (LGN) of the cat is a major thalamic relay between the retina and several visual cortical areas. These cortical areas in turn project to the superior colliculus (SC). The aim of the present experiment was to determine which LGN layers provide a necessary input to the corticotectal circuit. 2. Individual layers of the LGN were reversibly inactivated by microinjection of cobalt chloride during recording of visual responses in the retinotopically corresponding part of the superior colliculus. 3. For cells driven through the contralateral eye, inactivation of layer A or the medial interlaminar nucleus (MIN) had little effect on visual responsiveness in the superior colliculus. In contrast, inactivation of layer C abolished visual responses at one-quarter of the SC recording sites, reduced responses at another quarter, and left half of the recording sites unaffected. 4. For cells driven through the ipsilateral eye, inactivation of layer C1 or the MIN had no effect. Inactivation of layer A1 uniformly reduced visual responses in the superior colliculus and usually abolished them entirely. 5. These results are compatible with previous work showing that cortical input to the SC originates from Y-cells. They indicate that two of the five Y-cell containing layers (A1 and C) provide major inputs to the corticotectal circuit. The results suggest that layer A1 is functionally allied to layer C as well as to layer A.

scholarly journals Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Thomas E. Krahe ◽  
Tania A. Seabrook ◽  
Ching-Kang J. Chen ◽  
Michael A. Fox ◽  
William Guido
Keyword(s):  
Visual Cortex ◽  
Lateral Geniculate Nucleus ◽  
Cortical Plasticity ◽  
Camp Response Element Binding ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Lateral Geniculate ◽  
Element Binding Protein ◽  
Sensory Activity ◽  
Visual Cortical ◽  
Dorsal Lateral Geniculate

The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth. While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.

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