scholarly journals Substance P is a functional neurotransmitter in the rat parotid gland.

1983 ◽  
Vol 342 (1) ◽  
pp. 483-498 ◽  
Author(s):  
D V Gallacher
Keyword(s):  
Substance P ◽  
Parotid Gland ◽  
Rat Parotid Gland ◽  
Rat Parotid

Substance P Effect on the Secretory Process in Rat Parotid Gland

1987 ◽  
pp. 195-196
Author(s):  
C. Dreux ◽  
V. Imhoff ◽  
P. Mauduit ◽  
B. Rossignol
Keyword(s):  
Substance P ◽  
Parotid Gland ◽  
Secretory Process ◽  
Rat Parotid Gland ◽  
Rat Parotid

scholarly journals Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glands

1983 ◽  
Vol 214 (3) ◽  
pp. 865-870 ◽  
Author(s):  
C P Downes ◽  
M D Dibner ◽  
M R Hanley
Keyword(s):  
Substance P ◽  
Parotid Gland ◽  
Membrane Lipid ◽  
Sympathetic Denervation ◽  
Parotid Glands ◽  
Surface Receptors ◽  
Alpha Adrenoceptor ◽  
Inositol Phospholipids ◽  
Rat Parotid Gland ◽  
Rat Parotid

Substance P, muscarinic and alpha-adrenoceptor agonists stimulated the incorporation of [3H]inositol into phosphatidylinositol in rat parotid gland slices. Surgical denervation of the sympathetic input to the rat parotid gland by superior cervical ganglionectomy produced marked reductions in these responses. The stimulated incorporation of radiolabelled precursors into phosphatidylinositol is a measure of its resynthesis after receptor-mediated breakdown of inositol phospholipids. We therefore examined the enzymic site of the lesion induced by sympathetic denervation using parotid gland slices labelled with either [3H]inositol or [32P]phosphate and stimulated with substance P. Receptor-activated phospholipase C attack upon [3H]inositol phospholipids was assayed by measuring the formation of [3H]inositol 1-phosphate in the presence of 10 mM-Li+ to inhibit further breakdown. It was not affected by denervation. Substance P elicited a rapid breakdown of phosphatidylinositol 4,5-bisphosphate and this response was reduced in the denervated gland. The second step in stimulated phosphatidylinositol turnover, phosphorylation of diacylglycerol to phosphatidate was not affected by denervation. Sympathetic denervation appears to induce a specific enzymic lesion in the parotid gland that impairs receptor-stimulated resynthesis of phosphatidylinositol from phosphatidate. This change in membrane lipid metabolism may be related to a number of the effects of sympathetic denervation, such as agonist supersensitivity, reduced gland cell proliferation and induction of new surface receptors.

Effect of substance P C-terminal heptapeptide on amylase release in rat parotid gland

1980 ◽  
Vol 25 (8-9) ◽  
pp. 597-600 ◽  
Author(s):  
Akifumi Togari ◽  
Takeshi Kato ◽  
Toshiharu Nagatsu
Keyword(s):  
Substance P ◽  
Parotid Gland ◽  
Amylase Release ◽  
Rat Parotid Gland ◽  
Rat Parotid

Effect of anti-substance P anti-idiotypic antibodies on the secretory process in the rat parotid gland

1988 ◽  
Vol 22 (1-2) ◽  
pp. 118
Author(s):  
S. Maillet ◽  
V. Imhoff ◽  
I. Rollandy ◽  
C. Dreux ◽  
P. Pradelles ◽  
...  
Keyword(s):  
Substance P ◽  
Parotid Gland ◽  
Secretory Process ◽  
Rat Parotid Gland ◽  
Rat Parotid
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