scholarly journals Long-term potentiation in commissural and Schaffer projections to hippocampal CA1 cells: an in vivo study in the rat.

1983 ◽  
Vol 341 (1) ◽  
pp. 617-626 ◽  
Author(s):  
T V Bliss ◽  
B Lancaster ◽  
H V Wheal
Keyword(s):  
Long Term Potentiation ◽  
In Vivo Study ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Ca1 Cells

Effect of high-fat diet and antioxidants on hippocampal long-term potentiation in rats: An in vivo study

2013 ◽  
Vol 1539 ◽  
pp. 1-6 ◽  
Author(s):  
Seyed Asaad Karimi ◽  
Iraj Salehi ◽  
Alireza Komaki ◽  
Abdolrahman Sarihi ◽  
Mohammad Zarei ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Long Term Potentiation ◽  
In Vivo Study ◽  
High Fat ◽  
Term Potentiation

Effect of garlic powder on hippocampal long-term potentiation in rats fed high fat diet: an in vivo study

2018 ◽  
Vol 33 (3) ◽  
pp. 725-731 ◽  
Author(s):  
Iraj Salehi ◽  
Alireza Komaki ◽  
Seyed Asaad Karimi ◽  
Abdolrahman Sarihi ◽  
Mohammad Zarei
Keyword(s):  
High Fat Diet ◽  
Long Term Potentiation ◽  
In Vivo Study ◽  
High Fat ◽  
Garlic Powder ◽  
Term Potentiation

Hippocampal long term potentiation in rats under different regimens of vitamin D: An in vivo study

2012 ◽  
Vol 509 (1) ◽  
pp. 56-59 ◽  
Author(s):  
Mahmoud Salami ◽  
Sayyed Alireza Talaei ◽  
Saeideh Davari ◽  
Mohsen Taghizadeh
Keyword(s):  
Vitamin D ◽  
Long Term Potentiation ◽  
In Vivo Study ◽  
Term Potentiation

scholarly journals Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
James E. Orfila ◽  
Nicole McKinnon ◽  
Myriam Moreno ◽  
Guiying Deng ◽  
Nicholas Chalmers ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Brain Slices ◽  
Glucose Deprivation ◽  
Long Term Potentiation ◽  
Global Brain Ischemia ◽  
Term Potentiation ◽  
Hippocampal Ca1

Ischemic long-term potentiation (iLTP) is a form of synaptic plasticity that occurs in acute brain slices following oxygen-glucose deprivation. In vitro, iLTP can occlude physiological LTP (pLTP) through saturation of plasticity mechanisms. We used our murine cardiac arrest and cardiopulmonary resuscitation (CA/CPR) model to produce global brain ischemia and assess whether iLTP is induced in vivo, contributing to the functionally relevant impairment of pLTP. Adult male mice were subjected to CA/CPR, and slice electrophysiology was performed in the hippocampal CA1 region 7 or 30 days later. We observed increased miniature excitatory postsynaptic current amplitudes, suggesting a potentiation of postsynaptic AMPA receptor function after CA/CPR. We also observed increased phosphorylated GluR1 in the postsynaptic density of hippocampi after CA/CPR. These data support the in vivo induction of ischemia-induced plasticity. Application of a low-frequency stimulus (LFS) to CA1 inputs reduced excitatory postsynaptic potentials in slices from mice subjected to CA/CPR, while having no effects in sham controls. These results are consistent with a reversal, or depotentiation, of iLTP. Further, depotentiation with LFS partially restored induction of pLTP with theta burst stimulation. These data provide evidence for iLTP following in vivo ischemia, which occludes pLTP and likely contributes to network disruptions that underlie memory impairments.

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