scholarly journals Aldosterone on sodium transport of rat distal colon in long-term adrenalectomy during acute and chronic substitution

1983 ◽  
Vol 340 (1) ◽  
pp. 503-511 ◽  
Author(s):  
Michael Horster ◽  
Andreas Lückhoff
Keyword(s):  
Sodium Transport ◽  
Distal Colon ◽  
Rat Distal Colon

Effect of aldosterone and dexamethasone pretreatment on sodium transport in rat distal colon in vitro

1984 ◽  
Vol 400 (3) ◽  
pp. 257-261 ◽  
Author(s):  
R. D. Perrone ◽  
E. A. Alexander ◽  
H. H. Bengele ◽  
J. H. Schwartz
Keyword(s):  
Sodium Transport ◽  
Distal Colon ◽  
Rat Distal Colon

Adenosine A3 receptor expression in peplidergic neural circuits of the rat distal colon

2001 ◽  
Vol 120 (5) ◽  
pp. A177-A177
Author(s):  
S SHARP ◽  
J YU ◽  
J GUZMAN ◽  
J XUE ◽  
H COOKE ◽  
...  
Keyword(s):  
Neural Circuits ◽  
Distal Colon ◽  
Receptor Expression ◽  
Adenosine A3 Receptor ◽  
Rat Distal Colon

scholarly journals Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers

Gut ◽  
2021 ◽  
pp. gutjnl-2020-322545
Author(s):  
Han-Mo Chiu ◽  
Grace Hsiao-Hsuan Jen ◽  
Ying-Wei Wang ◽  
Jean Ching-Yuan Fann ◽  
Chen-Yang Hsu ◽  
...  
Keyword(s):  
Large Scale ◽  
Distal Colon ◽  
Population Based ◽  
Proximal Colon ◽  
Advanced Stage ◽  
Site Specific ◽  
Faecal Immunochemical Test ◽  
Immunochemical Test ◽  
Selection Factors

ObjectiveTo measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening.DesignA prospective cohort study of Taiwanese nationwide biennial FIT screening was performed. A total of 5 417 699 eligible subjects were invited to attend screening from 2004 through 2009 and were followed up until 2014. We estimated the adjusted relative rates (aRRs) on the effectiveness of reducing advanced-stage CRC (stage II+) and CRC death by Bayesian Poisson regression models with the full adjustment for a cascade of self-selection factors (including the screening rate and the colonoscopy rate) and the completeness of colonoscopy together with demographic features.ResultsFIT screening (exposed vs unexposed) reduced the incidence of advanced-stage CRC (48.4 vs 75.7 per 100 000) and mortality (20.3 vs 41.3 per 100 000). Statistically significant reductions of both incidence of advanced-stage CRCs (aRR=0.66, 95% CI 0.63 to 0.70) and deaths from CRC (aRR=0.60, 95% CI 0.57 to 0.64) were noted. FIT screening was more effective in reducing distal advanced-stage CRCs (aRR=0.61, 95% CI 0.58 to 0.64) and CRC mortality (aRR=0.56, 95% CI 0.53 to 0.69) than proximal advanced CRCs (aRR=0.84, 95% CI 0.77 to 0.92) and CRC mortality (aRR=0.72, 95% CI 0.66 to 0.80).ConclusionA large-scale population-based biennial FIT screening demonstrates 34% significant reduction of advanced-stage CRCs and 40% reduction of death from CRC with larger long-term effectiveness in the distal colon than the proximal colon. Our findings provide a strong and consistent evidence-based policy for supporting a sustainable population-based FIT organised service screening worldwide. The disparity of site-specific long-term effectiveness also provides an insight into the remedy for lower effectiveness of FIT screening in the proximal colon.

Fibre-free diet leads to impairment of neuronally mediated muscle contractile response in rat distal colon

2006 ◽  
Vol 18 (12) ◽  
pp. 1093-1101 ◽  
Author(s):  
r. mitsui ◽  
s.-i. karaki ◽  
y. kubo ◽  
y. sugiura ◽  
a. kuwahara
Keyword(s):  
Contractile Response ◽  
Distal Colon ◽  
Rat Distal Colon ◽  
Muscle Contractile

Dietary fish oils decrease bradykinin-induced secretion in rat distal colon

1997 ◽  
Vol 17 (4) ◽  
pp. 693-702 ◽  
Author(s):  
Kumiko Yamazaki ◽  
Takaji Yajima ◽  
Tamotsu Kuwata
Keyword(s):  
Distal Colon ◽  
Fish Oils ◽  
Rat Distal Colon ◽  
Dietary Fish

Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon

2008 ◽  
Vol 581 (1-2) ◽  
pp. 164-170 ◽  
Author(s):  
Libor Mrnka ◽  
Miroslav Hock ◽  
Markéta Rybová ◽  
Jiří Pácha
Keyword(s):  
Prostaglandin E2 ◽  
Sodium Nitroprusside ◽  
Distal Colon ◽  
Ion Secretion ◽  
Rat Distal Colon

Bicarbonate secretion in rat distal colon in vitro: a measurement technique

1988 ◽  
Vol 254 (3) ◽  
pp. C383-C390 ◽  
Author(s):  
G. M. Feldman ◽  
S. F. Berman ◽  
R. L. Stephenson
Keyword(s):  
Short Circuit ◽  
Distal Colon ◽  
Apparent Permeability ◽  
Chemical Gradients ◽  
Acid Generation ◽  
Rat Distal Colon ◽  
Tissue Surfaces ◽  
Apparent Permeability Coefficient ◽  
Transepithelial Voltage

To study HCO3- secretion in rat distal colon, we utilized a technique that permits control of electrical and chemical transepithelial gradients. With symmetrical solutions (pH 7.4, [HCO3-] 25 mM, and CO2 tension 40 mmHg) bathing both tissue surfaces and under short-circuit conditions, HCO3- secretion remained stable for greater than 4 h at 1 mueq. h-1.cm-2. As the mucosal solution was alkalinized, the serosal solution was acidified at 3.1 mueq.h-1.cm-2. Ninety-four percent of serosal acidification was accounted for by the rate of metabolic lactic acid generation and transepithelial HCO3- secretion. Clamping transepithelial voltage reversibly affected net HCO3- secretion, and a linear relationship existed between clamped mucosal voltage and net HCO3- flux (r = 0.99); mucosal voltage of -68 mV completely inhibited net secretion. The apparent permeability coefficient of the colon to HCO3- is 2.8 X 10(-6) cm/s. One millimolar ouabain completely inhibited net HCO3- secretion. Acetazolamide (10(-4) M) inhibited secretion by approximately 50%, whereas a 10(-3) M concentration inhibited secretion by 90%. These data demonstrate that net colonic HCO3- secretion can be measured without imposed electrical and chemical gradients and that this flux is voltage sensitive and depends on carbonic anhydrase and Na+-K+-ATPase activities.

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