scholarly journals Central gating of developmental plasticity in kitten visual cortex

1982 ◽  
Vol 324 (1) ◽  
pp. 221-237 ◽  
Author(s):  
W. Singer ◽  
F. Tretter ◽  
U. Yinon
Keyword(s):  
Visual Cortex ◽  
Developmental Plasticity

Blockade of postsynaptic activity in sleep inhibits developmental plasticity in visual cortex

Neuroreport ◽  
2006 ◽  
Vol 17 (13) ◽  
pp. 1459-1463 ◽  
Author(s):  
Marcos G. Frank ◽  
Sushil K. Jha ◽  
Tammi Coleman
Keyword(s):  
Visual Cortex ◽  
Developmental Plasticity ◽  
Postsynaptic Activity

Early visual experience, learning, and neurochemical plasticity in the rat and the chick

1977 ◽  
Vol 278 (961) ◽  
pp. 307-318 ◽  
Keyword(s):  
Visual Cortex ◽  
Rna Synthesis ◽  
Developmental Plasticity ◽  
Light Exposure ◽  
Anterior Forebrain ◽  
Sensory Activity ◽  
Flashing Light ◽  
Neurochemical Plasticity ◽  
Protein Incorporation ◽  
Neurochemical Correlates

Rats reared in the dark to 50 days show morphological and biochemical changes in the visual pathway. Light exposure results in elevated incorporation into protein in visual cortex, lateral geniculate and retina. Much of the visual cortex elevation is in a rapidly labelling, rapidly transported neuronal particulate protein. There are concomitant changes in lysosomal and transmitter enzyme activity. In chicks exposed to an imprinting stimulus (a flashing light) there are elevations in RNA polymerase and RNA and protein incorporation in the anterior forebrain roof (a.f.r.) compared with controls. There are changes in adenyl cyclase, cAMP and AChE. Behavioural controls show that although there are general biochemical sequelae of light exposure, the elevation in RNA synthesis in the a.f.r. is not a result of mo tor, stress or sensory activity, but is correlated wih a measure of the learning of the stimulus characteristics. A model for neurochemical correlates of developmental plasticity, learning, and statedependent transients is discussed.

scholarly journals Developmental plasticity in visual cortex is necessary for normal visuomotor integration and visuomotor skill learning

2021 ◽  
Author(s):  
Felix C Widmer ◽  
Georg B Keller
Keyword(s):  
Visual Cortex ◽  
Early Life ◽  
Developmental Plasticity ◽  
Visual Experience ◽  
Skill Learning ◽  
Conditional Knockout ◽  
Visuomotor Integration ◽  
Visuomotor Task ◽  
Visuomotor Skills

The experience of coupling between motor output and visual feedback is necessary for the development of visuomotor skills and shapes visuomotor integration in visual cortex. Whether these experience-dependent changes involve plasticity in visual cortex remains unclear. Here, we probed the role of NMDA receptor-dependent plasticity in mouse primary visual cortex (V1) during visuomotor development. Using a conditional knockout of NMDA receptors and a photoactivatable inhibitor of CaMKII, we locally perturbed plasticity in V1 during first visual experience, recorded neuronal activity in V1, and tested the mice in a visuomotor task. We found that perturbing plasticity before, but not after, first visuomotor experience reduces responses to unpredictable stimuli, diminishes the suppression of predictable feedback in V1, and impairs visuomotor skill learning later in life. Our results demonstrate that plasticity in the local V1 circuit during early life is critical for shaping visuomotor integration.

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