scholarly journals Intracellular calcium accumulation during depolarization in a molluscan neurone.

1980 ◽  
Vol 308 (1) ◽  
pp. 259-285 ◽  
Author(s):  
A L Gorman ◽  
M V Thomas
Keyword(s):  
Intracellular Calcium ◽  
Calcium Accumulation ◽  
Molluscan Neurone

scholarly journals Effects of Propentofylline on Hypoxia—Hypoglycemia-Induced Calcium Accumulation in Gerbil Hippocampal Slices

1992 ◽  
Vol 12 (2) ◽  
pp. 301-305 ◽  
Author(s):  
Fumito Kadoya ◽  
Akira Mitani ◽  
Tatsuru Arai ◽  
Kiyoshi Kataoka
Keyword(s):  
Cerebral Ischemia ◽  
Intracellular Calcium ◽  
Neuronal Damage ◽  
Hippocampal Slices ◽  
Dependent Manner ◽  
Protective Effects ◽  
Calcium Accumulation ◽  
Xanthine Derivative ◽  
Acute Increase ◽  
Dose Dependent

The xanthine derivative propentofylline (HWA 285) has been reported to show protective effects against neuronal damage induced by cerebral ischemia. In the present study, microfluorometry was used to investigate the effect of propentofylline on the hypoxia–hypoglycemia-induced intracellular calcium accumulation in gerbil hippocampal slices. When slices were superfused with hypoxic–hypoglycemic medium that did not contain propentofylline, an acute increase in calcium accumulation was detected 75–200 s (mean latency of 123 s) after the beginning of hypoxia–hypoglycemia. When slices were superfused with hypoxic–hypoglycemic mediums that contained 10 μ M, 100 μ M, and 1 m M propentofylline, the latency of the acute increase in calcium accumulation was prolonged in all subregions of the hippocampus in a dose-dependent manner: mean latencies in field CA1 were 146, 168, and 197 s after hypoxia–hypoglycemia, respectively. This retardation in calcium accumulation may be involved in the mechanisms by which propentofylline diminishes ischemic injury.

scholarly journals From aldosteronism to oxidative stress: the role of excessive intracellular calcium accumulation

2010 ◽  
Vol 33 (11) ◽  
pp. 1091-1101 ◽  
Author(s):  
Ayhan A Zia ◽  
German Kamalov ◽  
Kevin P Newman ◽  
Jesse E McGee ◽  
Syamal K Bhattacharya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intracellular Calcium ◽  
Calcium Accumulation
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