scholarly journals Relationship between hydrogen ion concentration and flow of gastric juice during inhibition of gastric secretion in the cat.

1980 ◽  
Vol 306 (1) ◽  
pp. 51-63 ◽  
Author(s):  
B H Hirst ◽  
L A Labib ◽  
J D Reed ◽  
J G Stephen
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Hydrogen Ion ◽  
Ion Concentration ◽  
Hydrogen Ion Concentration ◽  
Inhibition Of Gastric Secretion

The Relation between the Rate of Production of Gastric Juice and its Electrolyte Concentrations

1970 ◽  
Vol 39 (1) ◽  
pp. 61-75 ◽  
Author(s):  
M. Hobsley ◽  
W. Silen
Keyword(s):  
Linear Relationship ◽  
Gastric Juice ◽  
Chloride Ion ◽  
Hydrogen Ion ◽  
Ion Concentration ◽  
Hydrogen Ion Concentration ◽  
Acid Component ◽  
Volume Rate ◽  
Fixed Composition ◽  
Analytical Errors

1. Repeated 15-min collections of gastric juice were made during the plateau of response to an intravenous infusion of histamine diphosphate 0·01 mg h−1 kg−1 and the samples measured and their electrolyte concentrations estimated. A linear relationship was found between chloride output and the volume-rate of overall secretion and between hydrogen ion output and the same rate of secretion, while a multivariate linear relationship was also found between all three variables. 2. A mathematical analysis of these results suggests that if gastric secretion consists of an acid and a non-acid component, each of fixed composition, then the acid component has the composition H = 143 mEq/l, K = 16 mEq/l, Cl = 169 mEq/l, and the non-acid component is secreted at the same rate in different subjects under these circumstances. 3. The data enable gross sampling and analytical errors to be detected; in particular, the volume-rate of secretion can be predicted from hydrogen ion concentration, better from chloride ion concentration, and best from the concentrations of both ions. 4. For single samples such predictions appear to be superior to the direct measurement of volume.

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