scholarly journals Dark adaptation within the receptive field centre of rat retinal ganglion cells.

1980 ◽  
Vol 301 (1) ◽  
pp. 535-548 ◽  
Author(s):  
C M Cicerone ◽  
D G Green
Keyword(s):  
Receptive Field ◽  
Retinal Ganglion Cells ◽  
Dark Adaptation ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Receptive Field Centre

scholarly journals Spatial receptive field properties of rat retinal ganglion cells

2011 ◽  
Vol 28 (5) ◽  
pp. 403-417 ◽  
Author(s):  
WALTER F. HEINE ◽  
CHRISTOPHER L. PASSAGLIA
Keyword(s):  
Receptive Field ◽  
Ganglion Cell ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Cell Types ◽  
Quantitative Information ◽  
Retinal Ganglion ◽  
X And Y Cells ◽  
Y Cells

AbstractThe rat is a popular animal model for vision research, yet there is little quantitative information about the physiological properties of the cells that provide its brain with visual input, the retinal ganglion cells. It is not clear whether rats even possess the full complement of ganglion cell types found in other mammals. Since such information is important for evaluating rodent models of visual disease and elucidating the function of homologous and heterologous cells in different animals, we recorded from rat ganglion cells in vivo and systematically measured their spatial receptive field (RF) properties using spot, annulus, and grating patterns. Most of the recorded cells bore likeness to cat X and Y cells, exhibiting brisk responses, center-surround RFs, and linear or nonlinear spatial summation. The others resembled various types of mammalian W cell, including local-edge-detector cells, suppressed-by-contrast cells, and an unusual type with an ON–OFF surround. They generally exhibited sluggish responses, larger RFs, and lower responsiveness. The peak responsivity of brisk-nonlinear (Y-type) cells was around twice that of brisk-linear (X-type) cells and several fold that of sluggish cells. The RF size of brisk-linear and brisk-nonlinear cells was indistinguishable, with average center and surround diameters of 5.6 ± 1.3 and 26.4 ± 11.3 deg, respectively. In contrast, the center diameter of recorded sluggish cells averaged 12.8 ± 7.9 deg. The homogeneous RF size of rat brisk cells is unlike that of cat X and Y cells, and its implication regarding the putative roles of these two ganglion cell types in visual signaling is discussed.

Involvement of glycinergic neurons in the diminished surround activity of ganglion cells in the dark-adapted rabbit retina

1991 ◽  
Vol 6 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Ralph J. Jensen
Keyword(s):  
Retinal Ganglion Cells ◽  
Dopaminergic Neurons ◽  
Dark Adaptation ◽  
Ganglion Cells ◽  
Dopamine Antagonist ◽  
Intracellular Camp ◽  
Rabbit Retina ◽  
Retinal Ganglion ◽  
Camp Levels ◽  
Dependent Mechanism

AbstractPrevious studies have reported that the surround responses of retinal ganglion cells weaken or disappear upon dark adaptation. The mechanism(s) by which this occurs is largely unknown, although changes in activity of retinal dopaminergic neurons have been implicated. In the light-adapted rabbit retina, the surround ON responses of OFF-center ganglion cells have been shown to be markedly reduced or abolished by a dopamine antagonist. This effect of a dopamine antagonist was recently shown to be reversed by the glycine antagonist strychnine and by compounds that elevate intracellular cAMP levels. The present study was conducted to determine whether strychnine and cAMP-elevating compounds could bring out the surround ON responses in OFF-center ganglion cells that are diminished upon dark adaptation. Extracellular recordings of OFF-center brisk ganglion cells were made from isolated, superfused retinal preparations. During the course of dark adaptation, the surround On responses of many cells decreased markedly.Application in both brisk-transient and brisk-sustained OFF-center ganglion cells. The center OFF responses of these cells, on the other hand, were not enhanced by strychnine. Of the cAMP-elevating compounds tested, 8-(4-chlorophenylthio) cyclic AMP was the most effective in bringing out the surround ON responses in dark-adapted OFF-center ganglion cells. The findings from this study suggest that under dark-adapted conditions glycinergic neurons inhibit the surround component of OFF-center ganglion cells. The release of glycine from these neurons is suggested to be regulated by a cAMP-dependent mechanism.

scholarly journals Transient Responses of Rabbit Retinal Ganglion Cells to Photic and Electrical Stimuli

1976 ◽  
Vol 3 (1) ◽  
pp. 73-79 ◽  
Author(s):  
S. Molotchnikoff
Keyword(s):  
Receptive Field ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Electrical Activation ◽  
Retinal Ganglion ◽  
Transient Responses ◽  
Long Latency ◽  
Latency Response ◽  
Electrical Stimuli ◽  
Inhibitory Period

SUMMARY:The relationships between the center and the surround of the receptive field of the rabbit retinal ganglion cell were investigated. This was done by coupling localized light spots and electrical activation of the retina and by analyzing the time of the excitatory and inhibitory periods. The responsiveness to the electrical transretinal pulse revealed a) that ON stimulation in OFF-center cells and OFF stimulation in ON-center cells, elicited a primary period of inhibition with a short latency; b) the long latency response of surround stimulation was not preceded by an inhibitory period unless the center was simultaneously stimulated in the same direction; c) a transient response to a stationary spot of light is followed by a period of inhibition. These results are discussed in relation to the known cellular retinal networks.

Sign in / Sign up

Export Citation Format

Share Document