scholarly journals Central respiratory effects of carbon dioxide, and carotid sinus nerve and muscle afferents.

1980 ◽  
Vol 300 (1) ◽  
pp. 75-87 ◽  
Author(s):  
F L Eldridge ◽  
P Gill-Kumar
Keyword(s):  
Carbon Dioxide ◽  
Carotid Sinus ◽  
Muscle Afferents ◽  
Carotid Sinus Nerve ◽  
Respiratory Effects

scholarly journals Respiratory Effects of Division of the Carotid Sinus Nerve in the Lamb Soon After the Initiation of Breathing

1968 ◽  
Vol 2 (4) ◽  
pp. 264-270 ◽  
Author(s):  
H S Harned ◽  
R T Herrington ◽  
C A Griffin ◽  
W S Berryhill ◽  
L G MacKinney
Keyword(s):  
Carotid Sinus ◽  
Carotid Sinus Nerve ◽  
Respiratory Effects

Projections of the carotid sinus nerve to the medulla in the dog

1987 ◽  
Vol 18 (3) ◽  
pp. 437-445 ◽  
Author(s):  
Cheryl L. Chernicky ◽  
Karen L. Barnes ◽  
Carlos M. Ferrario ◽  
John P. Conomy
Keyword(s):  
Carotid Sinus ◽  
Carotid Sinus Nerve

Effect of a synthetic progestin on ventilatory response to hypoxia in anesthetized rats

1989 ◽  
Vol 67 (5) ◽  
pp. 1754-1758 ◽  
Author(s):  
H. Kimura ◽  
M. Mikami ◽  
T. Kuriyama ◽  
Y. Fukuda
Keyword(s):  
Regulatory Mechanism ◽  
Carotid Sinus ◽  
Ventilatory Response ◽  
Break Point ◽  
Male Rat ◽  
Carotid Sinus Nerve ◽  
Ventilatory Responses ◽  
Chlormadinone Acetate ◽  
Ventilatory Depression ◽  
Ventilatory Response To Hypoxia

Effects on ventilatory responses to progressive isocapnic hypoxia of a synthetic potent progestin, chlormadinone acetate (CMA), were determined in the halothane-anesthetized male rat. Ventilation during the breathing of hyperoxic gas was largely unaffected by treatment with CMA when carotid chemoreceptor afferents were kept intact. The sensitivity to hypoxia evaluated by hyperbolic regression analysis of the response curve did not differ between the control and CMA groups. The reduction of ventilation after bilateral section of the carotid sinus nerve (CSN) in hyperoxia was less severe in CMA-treated than in untreated animals. Furthermore, the CMA-treated rats showed a larger increase in ventilation during the hypoxia test and a lower PO2 break point for ventilatory depression. Inhibition of hypoxic ventilatory depression by CMA persisted even after the denervation of CSN. We conclude that exogenous progestin likely protects regulatory mechanism(s) for respiration against hypoxic depression through a stimulating action independent of carotid chemoreceptor afferents and without a change in the sensitivity of the ventilatory response to hypoxia.

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