scholarly journals Acute compensatory adaptation of renal function following contralateral kidney exclusion in Brattleboro rats with diabetes insipidus.

1978 ◽  
Vol 283 (1) ◽  
pp. 425-438 ◽  
Author(s):  
D G Shirley ◽  
J Skinner
Keyword(s):  
Renal Function ◽  
Diabetes Insipidus ◽  
Brattleboro Rats ◽  
Contralateral Kidney ◽  
Compensatory Adaptation

Antidiuretic antagonism and agonism of 1-deamino-pentamethylene-2-d-phenylalanine-4-isoleucine-arginine vasopressin in rats with diabetes insipidus

1987 ◽  
Vol 112 (3) ◽  
pp. 439-442 ◽  
Author(s):  
H. Vilhardt ◽  
S. Lundin
Keyword(s):  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Test Model ◽  
Brattleboro Rats ◽  
Experimental Conditions ◽  
Vasopressin Antagonist ◽  
Agonist Action

ABSTRACT Using implanted minipumps it was shown over a period of 7 days that the vasopressin antagonist, 1-deamino-pentamethylene-2-d-Phe-4-Ile-arginine vasopressin, caused increased diuresis in normal rats and reversed vasopressin- or oxytocin-induced antidiuresis in Brattleboro rats. When the antagonist was infused alone in Brattleboro rats it induced a marked antidiuretic response, indicating that the analogue also possessed agonistic properties. The agonist action could not be demonstrated in anaesthetized, hydrated normal rats. In these animals the analogue behaved as a pure antagonist. It is concluded that analogues which behave as antagonists in one test model may display agonistic properties under different experimental conditions. J. Endocr. (1987) 112, 439–442

UNILATERAL MULTICYSTIC KIDNEY IN INFANTS

PEDIATRICS ◽  
1949 ◽  
Vol 4 (6) ◽  
pp. 769-781
Author(s):  
MARK M. RAVITCH ◽  
MARSHALL C. SANFORD
Keyword(s):  
Renal Function ◽  
Abdominal Mass ◽  
Progressive Increase ◽  
Contralateral Kidney ◽  
Multicystic Kidney

Four infants are reported with unilateral replacement of the kidney by large cysts. These cases and six similar ones found in the literature show: (a) a large abdominal mass producing pressure symptoms only; (b) a normal contralateral kidney; (c) progressive increase in size of the mass; (d) adequate renal function after resection of the involved kidney.

Effects of growth hormone and IGF-I on renal function in rats with normal and reduced renal mass

1990 ◽  
Vol 259 (5) ◽  
pp. F747-F751 ◽  
Author(s):  
S. B. Miller ◽  
V. A. Hansen ◽  
M. R. Hammerman
Keyword(s):  
Growth Hormone ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Mass ◽  
Filtration Rate ◽  
Inulin Clearance ◽  
Mass Reduction ◽  
Contralateral Kidney ◽  
Igf I

To characterize actions of growth hormone (GH) and insulin-like growth factor ( (IGF-I) on renal function in rats with normal and reduced renal mass, we administered recombinant bovine growth hormone (bGH) or human IGF-I (hIGF-I) to normal rats or to rats that had undergone unilateral nephrectomy and two-thirds infarction of the contralateral kidney, and measured inulin and p-aminohippurate clearances over 10-17 days. Administration of either bGH (100-200 micrograms/day) or hIGF-I (200 micrograms/day) to rats with normal renal mass increased inulin and p-aminohippurate clearances compared with those measured in animals that received vehicle. Filtration fractions were not affected by either bGH or hIGF-I. Inulin clearance was decreased to approximately 17% of normal 1 day after reduction of renal mass in rats. Over the next 3 days insulin clearance increased significantly in rats with reduced renal mass that were administered vehicle. No further enhancement occurred during the next 7 days. Neither bGH nor hIGF-I affected inulin clearance in rats with reduced renal mass. We conclude that both GH and IGF-I enhance glomerular filtration rate when administered to rats with normal renal mass, but not when administered in the same quantities to rats in which renal functional mass is reduced. Glomerular filtration rate increases within 4 days of renal mass reduction independent of exogenous GH or IGF-I.

scholarly journals Adaptive functional change of the contralateral kidney after partial nephrectomy

2017 ◽  
Vol 313 (2) ◽  
pp. F192-F198 ◽  
Author(s):  
Se Young Choi ◽  
Sangjun Yoo ◽  
Dalsan You ◽  
In Gab Jeong ◽  
Cheryn Song ◽  
...  
Keyword(s):  
Renal Function ◽  
Partial Nephrectomy ◽  
Functional Change ◽  
Functional Changes ◽  
Contralateral Kidney ◽  
Before And After ◽  
Group 2 ◽  
American Society ◽  
American Society Of Anesthesiologists ◽  
Group 1

Partial nephrectomy aims to maintain renal function by nephron sparing; however, functional changes in the contralateral kidney remain unknown. We evaluate the functional change in the contralateral kidney using a diethylene triamine penta-acetic acid (DTPA) renal scan and determine factors predicting contralateral kidney function after partial nephrectomy. A total of 699 patients underwent partial nephrectomy, with a DTPA scan before and after surgery to assess the separate function of each kidney. Patients were divided into three groups according to initial contralateral glomerular filtration rate (GFR; group 1: <30 ml·min−1·1.73 m−2, group 2: 30–45 ml·min−1·1.73 m−2, and group 3: ≥45 ml·min−1·1.73 m−2). Multiple-regression analysis was used to identify the factors associated with increased GFR of the contralateral kidney over a 4-yr postoperative period. Patients in group 1 had a higher mean age and hypertension history, worse American Society of Anesthesiologists score, and larger tumor size than in the other two groups. The ipsilateral GFR changes at 4 yr after partial nephrectomy were −18.9, −3.6, and 3.9% in groups 1, 2, and 3, respectively, whereas the contralateral GFR changes were 10.8, 25.7, and 38.8%. Age [β: −0.105, 95% confidence interval (CI): −0.213; −0.011, P < 0.05] and preoperative contralateral GFR (β: −0.256, 95% CI: −0.332; −0.050, P < 0.01) were significant predictive factors for increased GFR of the contralateral kidney after 4 yr. The contralateral kidney compensated for the functional loss of the ipsilateral kidney. The increase of GFR in contralateral kidney is more prominent in younger patients with decreased contralateral renal function.

THE USE AND MODE OF ACTION OF ETHACRYNIC ACID IN NEPHROGENIC DIABETES INSIPIDUS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (3) ◽  
pp. 447-455
Author(s):  
David M. Brown ◽  
John W. Reynolds ◽  
Alfred F. Michael ◽  
Robert A. Ulstrom
Keyword(s):  
Renal Function ◽  
Diabetes Insipidus ◽  
Nephrogenic Diabetes Insipidus ◽  
Acid Metabolism ◽  
Ethacrynic Acid ◽  
Sodium Intake ◽  
Urine Volume ◽  
Free Water ◽  
Chloride Excretion ◽  
Diuretic Agents

The use of diuretic agents in the treatment of nephrogenic diabetes insipidus had been reported to result in decreased urine volume and decreased clearance of free water. A study of the use of ethacrynic acid, a potent saluretic agent, was instituted in patients with nephrogenic diabetes insipidus in an attempt to achieve a significant antidiuretic response while allowing a liberal sodium diet. Intravenous ethacrynic acid resulted in decreased urine volume, decreased clearance of free water and decreased RPF and GFR. Prolonged oral administration of ethacrynic acid promoted a significant antidiuretic response when the daily sodium intake was limited to 60 mEq. The effect of ethacrynic acid on renal function, potassium and chloride. excretion, and uric acid metabolism are discussed.

Renin content and excretory function of the kidney in rats with experimental hypertension

1962 ◽  
Vol 202 (4) ◽  
pp. 795-799 ◽  
Author(s):  
H. Brunner ◽  
P. A. Desaulles ◽  
D. Regoli ◽  
F. Gross
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Renal Hypertension ◽  
Experimental Hypertension ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Excretory Function ◽  
Contralateral Kidney ◽  
Ligation Of The Ureter ◽  
Renin Content

To determine relationship between kidney renin content and excretory function, rats with renal hypertension induced by unilateral clamping of the renal artery were given an oral load of 3 ml of 0.9% saline/100 g body wt. Excretion of the saline load was accelerated in rats with renal hypertension as well as in animals with hypertension due to overdosage with cortexone and salt, provided that the loading experiment was made 3–4 weeks after hypertension was established, but not when animals had been hypertensive for 11–14 weeks. Renin concentration was markedly reduced in the unclamped kidney and also in the kidney of the rats overdosed with cortexone and salt. Excreting capacity of the clamped kidney was compared with that of the unclamped kidney, after removal or after functional elimination of the contralateral kidney, by ligation of the ureter, 3, 24, and 48 hr after the operation. In all experiments excretion of saline load by the unclamped kidney was more rapid than by the clamped kidney, but the highest values were reached in the presence of a functional clamped kidney. Only in rats with elevated blood pressure was the load more rapidly excreted than in normal rats, but hypertension alone cannot be the only factor responsible, the excretion not being accelerated in unilaterally nephrectomized hypertensive rats. Although these hint at a connection between the renin concentration and renal function the nature of this relationship remains uncertain.

NaCl and Ca delivery at the bend of rat deep nephrons decreases during antidiuresis

1987 ◽  
Vol 252 (6) ◽  
pp. F1055-F1064 ◽  
Author(s):  
J. M. Elalouf ◽  
D. Chabane Sari ◽  
N. Roinel ◽  
C. de Rouffignac
Keyword(s):  
Parathyroid Hormone ◽  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Distal Tubule ◽  
Water Removal ◽  
Loop Of Henle ◽  
Brattleboro Rats ◽  
Previous Hypothesis

The effects of 1-desamino-8-D-arginine vasopressin (dDAVP) on superficial and juxtamedullary nephrons were investigated by micropuncture in diabetes insipidus (DI) Brattleboro rats chronically treated with the peptide. The rats, acutely deprived of endogenous calcitonin, parathyroid hormone (PTH), and glucagon [hormone-deprived (HD) rats], were examined either 4 days after cessation of dDAVP treatment (HDT, control diuretic rats) or when the treatment was continued until the micropuncture experiment, during which dDAVP was also given intravenously (HDT + dDAVP, experimental nondiuretic rats). In the presence of dDAVP, the reabsorption of Cl, Na, Mg, and Ca by the superficial loop of Henle was significantly increased, as previously observed in HD-untreated rats during acute infusion of dDAVP. The effects on the superficial distal tubule were also similar. The effects on K, however, were different both in the loop and in the distal tubule. At the bend of the juxtamedullary nephrons, the treatment alone (HDT rats) increased fractional delivery (FD%) of Na and Cl, whereas FD% of Mg, Ca, K, and P was unaltered. In HDT + dDAVP rats, FD% of H2O, Cl, Na, and Ca was significantly lower than in HDT rats, and FD% of K, Mg, and P did not differ significantly. In conclusion, in the presence of dDAVP, the FD% of H2O, Na, and Cl at the bend of the long-loop nephrons decreases, in accordance with our previous hypothesis that water removal along the rat descending limb increases outward NaCl diffusion along this segment.

scholarly journals Obstructive uropathy associated with primary ureteral endometrioma: case report and review of the literature

2013 ◽  
Vol 3 (3) ◽  
pp. 10
Author(s):  
Andrew Feifer ◽  
Mona Alam El-Din ◽  
Atilla Omeroglu ◽  
Maurice Anidjar
Keyword(s):  
Renal Function ◽  
Case Report ◽  
Postmenopausal Woman ◽  
Obstructive Uropathy ◽  
Flank Pain ◽  
Review Of The Literature ◽  
Gastrointestinal Complaint ◽  
Distal Ureter ◽  
Contralateral Kidney ◽  
Contrast Enhanced

We report the case of a 56-year-old postmenopausal woman whopresented with incidental left hydronephrosis during an investigationfor a gastrointestinal complaint. The patient denied any historyof flank pain or hematuria. Contrast-enhanced computedtomography revealed severe right-sided ureterohydronephrosis aswell as renal atrophy. The contralateral kidney was normal, as wasthe patient’s overall renal function. A retrograde ureterogramdemonstrated complete ureteral obstruction 4 cm proximal to theureterovesical junction. Subsequent ureteroscopy revealed a polypoidmass completely occupying the ureteral lumen, of which thebiopsies demonstrated inconclusive atypical urothelial changes.The patient underwent a laparoscopic nephrectomy with opendissection of the distal ureter. The patient recovered well postoperatively.Final pathology revealed a benign obstructingendometrioma without evidence of invasion from periureteraltissue. This appears to be the first reported case of asymptomaticprimary ureteral endometrioma with secondary renal atrophy.Earlier investigation and treatment may have allowed for renalpreservation earlier in the course of the disease.Nous décrivons le cas d’une femme ménopausée de 56 ans présentantune hydronéphrose gauche découverte de façon fortuite aucours d’un examen mené pour donner suite à des symptômes gastro-intestinaux. La patiente n’avait pas d’antécédents de douleurau flanc ou d’hématurie. Une TDM avec agent de contraste arévélé une urétéro-hydronéphrose droite importante accompagnéed’une atrophie rénale. Le rein controlatéral et la fonction rénaleglobale de la patiente ne présentaient aucune anomalie. Uneurétérographie par voie rétrograde a permis d’observer une obstructioncomplète de l’uretère proximale à 4 cm de la jonction urétérovésicale.Une urétéroscopie subséquente a révélé une masse polypoïdeoccupant la totalité de la lumière urétérale et des analysesaprès biopsie ont montré des changements atypiques non concluantsau niveau de l’épithélium urinaire. La patiente a subi unenéphrectomie par laparoscopie avec dissection ouverte de l’uretèredistale. La patiente s’est bien rétablie après l’intervention. Lerapport final de pathologie a révélé un endométriome obstructifbénin sans signe d’invasion des tissus péri-urétéraux. Il sembleque ce soit ici le premier cas signalé d’endométriome urétéralprimitif asymptomatique avec atrophie rénale secondaire. Un examenet un traitement réalisés plus tôt dans le cours de l’évolutionde la maladie auraient pu permettre la préservation du rein.

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