scholarly journals Activity of magnocellular neuroendocrine cells in the hypothalamus of unanaesthetized monkeys

1973 ◽  
Vol 232 (3) ◽  
pp. 545-572 ◽  
Author(s):  
James N. Hayward ◽  
David P. Jennings
Keyword(s):  
Neuroendocrine Cells ◽  
Magnocellular Neuroendocrine Cells

scholarly journals A Novel Role for Endogenous Pituitary Adenylate Cyclase Activating Polypeptide in the Magnocellular Neuroendocrine System

Endocrinology ◽  
2006 ◽  
Vol 147 (2) ◽  
pp. 791-803 ◽  
Author(s):  
E. R. Gillard ◽  
M. León-Olea ◽  
S. Mucio-Ramírez ◽  
C. G. Coburn ◽  
E. Sánchez-Islas ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Supraoptic Nucleus ◽  
Potential Role ◽  
Neuroendocrine System ◽  
Neuroendocrine Cells ◽  
Type I ◽  
Pituitary Adenylate Cyclase ◽  
Pacap Receptors ◽  
Magnocellular Neuroendocrine Cells

Central release of vasopressin (VP) by the magnocellular neuroendocrine cells (MNCs) responsible for systemic VP release is believed to be important in modulating the activity of these neurons during dehydration. Central VP release from MNC somata and dendrites is stimulated by both dehydration and pituitary adenylate cyclase activating polypeptide (PACAP). Although PACAP is expressed in MNCs, its potential role in the magnocellular response to dehydration is unexplored. The current study demonstrates that prolonged dehydration increases immunoreactivity for PACAP-27, PACAP-38, and the type I PACAP receptor in the supraoptic nucleus (SON) of the rat. In addition, PACAP stimulates local VP release in the euhydrated rat SON in vitro, and this effect is reduced by the PACAP receptor antagonist PAC6–27 (100 nm), suggesting the participation of PACAP receptors. Concomitant with its effects on local VP release, PACAP also reduces basal glutamate and aspartate release in the euhydrated rat SON. Furthermore, somatodendritic VP release elicited by acute dehydration is blocked by PAC6–27, suggesting that endogenous PACAP participates in this response. Consistent with this, RIA revealed that local PACAP-38 release within the SON is significantly elevated during acute dehydration. These results suggest that prolonged activation of hypothalamic MNCs is accompanied by up-regulation of PACAP and the type I PACAP receptor in these cells and that somatodendritic VP release in response to acute dehydration is mediated by activation of PACAP receptors by endogenous PACAP released within the SON. A potential role for PACAP in promoting efficient, but not exhaustive, systemic release of VP from MNCs during physiological challenge is discussed.

scholarly journals Perinatal exposure to organohalogen pollutants decreases vasopressin content and its mRNA expression in magnocellular neuroendocrine cells activated by osmotic stress in adult rats

2017 ◽  
Vol 329 ◽  
pp. 173-189 ◽  
Author(s):  
Samuel Mucio-Ramírez ◽  
Eduardo Sánchez-Islas ◽  
Edith Sánchez-Jaramillo ◽  
Margarita Currás-Collazo ◽  
Victor R. Juárez-González ◽  
...  
Keyword(s):  
Osmotic Stress ◽  
Mrna Expression ◽  
Neuroendocrine Cells ◽  
Perinatal Exposure ◽  
Adult Rats ◽  
Magnocellular Neuroendocrine Cells

Functional activation of punch-cultured magnocellular neuroendocrine cells by glutamate receptor subtypes

1999 ◽  
Vol 89 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Rick B Meeker ◽  
Margarita C Curras ◽  
Jay Stewart ◽  
Adriana Serje ◽  
Walid Al-Ghoul
Keyword(s):  
Glutamate Receptor ◽  
Neuroendocrine Cells ◽  
Receptor Subtypes ◽  
Magnocellular Neuroendocrine Cells
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