scholarly journals An electrophysiological analysis of the storage and release of noradrenaline at sympathetic nerve terminals

1973 ◽  
Vol 229 (2) ◽  
pp. 515-531 ◽  
Author(s):  
M. R. Bennett
Keyword(s):  
Sympathetic Nerve ◽  
Nerve Terminals ◽  
Release Of Noradrenaline ◽  
Electrophysiological Analysis

Exocytosis from Large and Small Dense Cored Vesicles in the Sympathetic Nerve Terminals of Guinea Pig and Man

1981 ◽  
Vol 39 ◽  
pp. 484-485
Author(s):  
Åsa Thureson-Klein ◽  
David J. Dzielak ◽  
Lennart Stjärne
Keyword(s):  
Chemical Composition ◽  
Guinea Pig ◽  
Sympathetic Nerve ◽  
Transmitter Release ◽  
Chromogranin A ◽  
Opioid Peptide ◽  
Morphological Evidence ◽  
Nerve Terminals ◽  
Exact Role ◽  
Release Of Noradrenaline

Large and small dense cored vesicles are present in various proportions in the noradrenergic nerve terminals of different species. These vesicles differ not only in size but in chemical composition as well. For example, only the large vesicles contain opioid peptide, a significant amount of matrix dopamine β-hydroxylase and measurable concentrations of chromogranin A. However, while much is known about the composition of isolated large and small vesicles their exact role in transmitter release is controversial. It has not been established to what extent large and small vesicles participate in exocytosis. Moreover, physiological and pharmacological experiments have indicated that there is not always a proportional co-release of noradrenaline and dopamine β-hydroxylase. The present study was performed to find morphological evidence for the hypothesis that both large and small vesicles can release transmitter but only the large vesicles release the enzyme.

scholarly journals Sympathetic nerve terminals in the tunica media of human superficial temporal and middle cerebral arteries: wet histofluorescence.

Stroke ◽  
1983 ◽  
Vol 14 (1) ◽  
pp. 62-66 ◽  
Author(s):  
I Akiguchi ◽  
H Fukuyama ◽  
M Kameyama ◽  
T Koyama ◽  
H Kimura ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Cerebral Arteries ◽  
Nerve Terminals ◽  
Tunica Media ◽  
Middle Cerebral Arteries

Stimulating actions of various prostaglandins and noradrenaline in strips of rabbit renal artery

1978 ◽  
Vol 56 (2) ◽  
pp. 321-323 ◽  
Author(s):  
F. Rioux ◽  
G. Gagnon ◽  
D. Regoli
Keyword(s):  
Renal Artery ◽  
Renal Arteries ◽  
Adrenergic Nerve ◽  
Prostaglandin E ◽  
Physiological Salt Solution ◽  
Nerve Terminals ◽  
Release Of Noradrenaline ◽  
Vasoconstrictor Effect ◽  
Adrenergic Nerve Terminals ◽  
Prostaglandins E

The myotropic effects of prostaglandins E1, E2, F2α, A1, and noradrenaline were evaluated in spirally cut strips of rabbit renal arteries suspended in a physiological salt solution maintained at 37 °C. The four prostaglandins as well as noradrenaline elicited contractions of the isolated rabbit renal artery. At concentrations higher than 1.0 × 10−7 g ml−1 the contracting effect of prostaglandin E1 diminished. The vasoconstrictor actions of prostaglandins E2 and F2α were potentiated by cocaine and inhibited by phentolamine. On the other hand, phentolamine did not inhibit the vasoconstrictor effect of prostaglandins E2 and F2α on strips of rabbit renal arteries removed from rabbits pretreated with reserpine. These results were taken as an indication that part of the contractile effects of prostaglandins E2 and F2α on the isolated rabbit renal artery may be due to the release of noradrenaline from adrenergic nerve terminals.

Chronic exposure to neuropeptide Y determines cardiac alpha 1-adrenergic responsiveness

1991 ◽  
Vol 261 (3) ◽  
pp. H969-H973 ◽  
Author(s):  
L. S. Sun ◽  
P. C. Ursell ◽  
R. B. Robinson
Keyword(s):  
Neuropeptide Y ◽  
Sympathetic Nerve ◽  
Chronic Exposure ◽  
Developmental Change ◽  
Sympathetic Innervation ◽  
Nerve Terminals ◽  
Cardiac Sympathetic Nerve ◽  
Cardiac Sympathetic Innervation ◽  
Chronotropic Response ◽  
Npy Antagonist

The onset of sympathetic innervation induces a developmental change in the cardiac alpha 1-adrenergic chronotropic response from an increase to a decrease in rate. The mechanism by which innervation induces this alteration is unknown. Neuropeptide Y (NPY), which is found abundantly in cardiac sympathetic nerve terminals, was considered as a possible mediator for this effect. Chronic conditioning by NPY in noninnervated myocyte cultures stimulated the effect of sympathetic innervation in inducing the alpha 1-inhibitory chronotropic response. Chronic conditioning by the NPY antagonist PYX-2 blocked the effect of innervation. Thus endogenous NPY may modulate alpha 1-adrenergic responsiveness during the ontogeny of cardiac sympathetic innervation.

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