scholarly journals Effects of noradrenaline and isoprenaline, in combination with α- and β-receptor blocking substances, on the action potential of cardiac Purkinje fibres

1973 ◽  
Vol 229 (1) ◽  
pp. 99-113 ◽  
Author(s):  
A. Giotti ◽  
F. Ledda ◽  
P. F. Mannaioni
Keyword(s):  
Action Potential ◽  
Purkinje Fibres ◽  
Receptor Blocking ◽  
Β Receptor ◽  
Cardiac Purkinje Fibres

Effects of seven drugs of abuse on action potential repolarisation in sheep cardiac Purkinje fibres

2005 ◽  
Vol 511 (2-3) ◽  
pp. 99-107 ◽  
Author(s):  
Robert D. Sheridan ◽  
Simon R. Turner ◽  
Graham J. Cooper ◽  
John E.H. Tattersall
Keyword(s):  
Action Potential ◽  
Drugs Of Abuse ◽  
Purkinje Fibres ◽  
Cardiac Purkinje Fibres

A Comparison of the Acute Haemodynamic Effects of Propranolol and Pindolol at Rest and during Supine Exercise in Man

1980 ◽  
Vol 59 (s6) ◽  
pp. 465s-468s ◽  
Author(s):  
T. L. Svendsen ◽  
J. E. Carlsen ◽  
O. Hartling ◽  
A. McNair ◽  
J. Trap-Jensen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiac Output ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Response Curves ◽  
Receptor Blocking ◽  
Artery Pressure ◽  
Arterial Blood ◽  
Β Receptor

1. Dose-response curves for heart rate, cardiac output, arterial blood pressure and pulmonary artery pressure were obtained in 16 male patients after intravenous administration of three increasing doses of pindolol, propranolol or placebo. All patients had an uncomplicated acute myocardial infarction 6–8 months earlier. 2. The dose-response curves were obtained at rest and during repeated bouts of supine bicycle exercise. The cumulative dose amounted to 0.024 mg/kg body weight for pindolol and to 0.192 mg/kg body weight for propranolol. 3. At rest propranolol significantly reduced heart rate and cardiac output by 12% and 15% respectively. Arterial mean blood pressure was reduced by 9.2 mmHg. Mean pulmonary artery pressure increased significantly by 2 mmHg. Statistically significant changes in these variables were not seen after pindolol or placebo. 4. During exercise pindolol and propranolol both reduced cardiac output, heart rate and arterial blood pressure to the same extent. After propranolol mean pulmonary artery pressure was increased significantly by 3.6 mmHg. Pindolol and placebo did not change pulmonary artery pressure significantly. 5. The study suggests that pindolol may offer haemodynamic advantages over β-receptor-blocking agents without intrinsic sympathomimetic activity during low activity of the sympathetic nervous system, and may be preferable in situations where the β-receptor-blocking effect is required only during physical or psychic stress.

scholarly journals Preclinical Profile of PF9404C, a Nitric Oxide Donor with β Receptor Blocking Properties

2006 ◽  
Vol 23 (2) ◽  
pp. 149-160 ◽  
Author(s):  
Mercedes Villarroya ◽  
Manuela G. López ◽  
Ricardo Pascual ◽  
Antonio G. García
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donor ◽  
Receptor Blocking ◽  
Β Receptor
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