scholarly journals Effect of renal nerve stimulation, renal blood flow and adrenergic blockade on plasma renin activity in the cat

1972 ◽  
Vol 226 (1) ◽  
pp. 15-36 ◽  
Author(s):  
J. H. Coote ◽  
E. J. Johns ◽  
Valerie H. Macleod ◽  
Bertha Singer
Keyword(s):  
Blood Flow ◽  
Plasma Renin Activity ◽  
Renal Blood Flow ◽  
Nerve Stimulation ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenergic Blockade ◽  
Renal Nerve ◽  
Renal Nerve Stimulation

Renal neuroadrenergic transmission

1975 ◽  
Vol 229 (1) ◽  
pp. 60-65 ◽  
Author(s):  
GL Slick ◽  
AJ Aguilera ◽  
EJ Zambraski ◽  
GF DiBona ◽  
GJ Kaloyanides
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Nerve Stimulation ◽  
Sodium Excretion ◽  
Sympathetic Nerves ◽  
Adrenergic Blockade ◽  
Renal Nerve ◽  
Group I ◽  
Renal Nerve Stimulation ◽  
Renal Sympathetic

To study the role of the renal sympathetic nerves in the regulation of sodium excretion, we examined the renal functional response to left renal nerve stimulation before (group I) and after (group II) left renal adrenergic blockade with guanethidine. In group I dogs, absolute sodium excretion from the left kidney fell markedly after left renal nerve stimulation; the decreases in glomerular filtration rate and renal blood flow were of a similar magnitude. Using the radiolabeled microsphere technique, distribution of renal blood flow to the outer cortex was diminished after left renal nerve stimulation. In group II dogs, guanethidine blocked all of these effects of left renal nerve stimulation. In group iii studies, a low level of left renal nerve stimulation was used which resulted in a decrease in sodium excretion in the absence of changes in glomerular filtration rate, renal blood flow, or intrarenal distribution of blood flow; this effect was blocked by renal adrenergic blockade with guanethidine in group iv studies. These data support a role for the renal sympathetic nerves to directly influence renal tubular sodium transport in the absence of alterations in renal hemodynamics.

Influence of Prostaglandins A1, E1, E2, and F2α on Renal Blood Flow and Plasma Renin Activity

1982 ◽  
Vol 5 (2) ◽  
pp. 57-67
Author(s):  
H.-H. Neumayer ◽  
K. Wagner ◽  
G. Schuhze ◽  
P. Laubner ◽  
M.K. Maiga ◽  
...  
Keyword(s):  
Blood Flow ◽  
Plasma Renin Activity ◽  
Renal Blood Flow ◽  
Plasma Renin ◽  
Renin Activity

Differential Efect of Noradrenaline and Renal Nerve Stimulation on Vascular Resistance in the Dog Kidney and the Release of a Prostaglandin E-Like Substance

1972 ◽  
Vol 42 (2) ◽  
pp. 223-233 ◽  
Author(s):  
J. C. McGiff ◽  
K. Crowshaw ◽  
N. A. Terragno ◽  
K. U. Malik ◽  
A. J. Lonigro
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Nerve Stimulation ◽  
Venous Blood ◽  
Urine Flow ◽  
Rapid Recovery ◽  
Prostaglandin E ◽  
Early Recovery ◽  
Renal Nerve ◽  
Renal Nerve Stimulation

1. The concentrations of prostaglandin E(PGE)- and prostaglandin F(PGF)-like substances in renal venous blood were determined by parallel bioassay of extracts of renal venous effluent before and during adrenergic stimulation of the kidney and were related to simultaneous measurements of renal blood flow and urine flow. 2. When noradrenaline was infused continuously into the renal artery, its initial vasoconstrictor and antidiuretic effects diminished on seven of eight occasions in six dogs. Rapid recovery of renal blood flow and urine flow was invariably associated with increasing concentration in renal venous blood of a substance having the physicochemical, chromatographic and biological properties of a prostaglandin of the E series. In the one instance when rapid early recovery of renal blood flow was not observed the concentration of PGE-like substance was not increased. 3. In contrast, during renal nerve stimulation early rapid recovery of renal blood flow and urine flow did not occur and the concentration of a PGE-like substance in renal venous blood did not increase. The concentration of a PGF-like substance in renal venous effluent did not increase in response to either stimulus. 4. Since PGE2, unlike PGF2α, is a potent renal vasodilator and diuretic, the intrarenal release of this substance by noradrenaline in concentrations similar to those determined for a PGE-like substance (>0·50 ng/ml assayed as PGE2 equivalents) would account for the changes in renal blood flow and urine flow in these experiments when the renal actions of noradrenaline were attenuated. 5. These results support the proposal that renal prostaglandins function in an intrarenal negative feedback control system which regulates antidiuretic and vasoconstrictor systems.

Oestrogen-induced changes in renal haemodynamics in the rat: Influence of plasma and intrarenal renin

1986 ◽  
Vol 71 (5) ◽  
pp. 613-619 ◽  
Author(s):  
Mr J. K. Evans ◽  
P. F. Naish ◽  
G. M. Aber
Keyword(s):  
Blood Flow ◽  
Plasma Renin Activity ◽  
Renal Blood Flow ◽  
Vascular Resistance ◽  
Peripheral Resistance ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Renal Haemodynamics ◽  
Renin Activity ◽  
Female Rats

1. The effect of oestrone acetate (in total doses of 5 and 10 mg) on systemic and renal haemodynamics and the renin-angiotensin system has been studied in adult female rats. 2. The administration of 10 mg of oestrogen resulted in a significant fall in renal blood flow associated with significant rises in both renal vascular resistance and mean arterial pressure. No changes were noted in cardiac output or total peripheral resistance at either dose. 3. Whilst the higher dose of oestrogen induced a significant increase in plasma renin activity, no change was noted in animals receiving 5 mg of oestrogen. Both regimens caused significant reductions in plasma and intrarenal renin concentrations. 4. Although renal blood flow correlated with plasma renin activity in animals with a normal renal blood flow, no such correlation was noted in animals with oestrogen-induced reductions in renal blood flow. 5. The present study demonstrates that oestrogen-induced reductions in renal blood flow result from a rise in intrarenal vascular resistance which cannot be accounted for by simultaneous changes in either plasma renin activity or renal renin concentration.

scholarly journals Vasoactive Drugs have Variable Effects on Plasma Renin Activity and Renal Blood Flow

1995 ◽  
Vol 80 (Supplement) ◽  
pp. SCA26
Author(s):  
L. D. Testa ◽  
R. L. Royster ◽  
D. D. Deal ◽  
M. Gowda ◽  
J. F. Butterworth
Keyword(s):  
Blood Flow ◽  
Plasma Renin Activity ◽  
Renal Blood Flow ◽  
Plasma Renin ◽  
Renin Activity ◽  
Vasoactive Drugs
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