scholarly journals The effects of vasopressin on the diuretic response to left atrial distension

1972 ◽  
Vol 221 (2) ◽  
pp. 427-440 ◽  
Author(s):  
J. R. Ledsome ◽  
J. M. Mason
Keyword(s):  
Left Atrial ◽  
Diuretic Response ◽  
Left Atrial Distension

Control of atrial natriuretic factor by right and left atrial distension in pregnant sheep

1995 ◽  
Vol 268 (6) ◽  
pp. R1411-R1417
Author(s):  
D. Javeshghani ◽  
S. Mukaddam-Daher ◽  
L. Fan ◽  
Z. Guan ◽  
J. Gutkowska ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Natriuretic Factor ◽  
Pregnant Sheep ◽  
Vascular Catheters ◽  
The Right ◽  
Left Atrial Distension ◽  
Atrial Natriuretic

Previous studies of the atrial stretch-atrial natriuretic factor (ANF) relationship during pregnancy have employed volume expansion and measured only right atrial pressure (RAP). Consequently, we studied nonpregnant (n = 7) and 115- to 125-day pregnant (n = 7) sheep and assessed the ANF response to changes of RAP and left atrial pressure (LAP) induced by graded balloon inflation. Ewes prepared with vascular catheters and atrial balloons were studied after recovery from preparatory surgical procedures. The basal levels of mean arterial pressure (MAP, 83 +/- 3 mmHg), RAP (2.1 +/- 0.7 mmHg), LAP (4.7 +/- 0.9 mmHg), and heart rate (HR, 102 +/- 6 beats/min) were similar in nonpregnant and pregnant sheep. Pregnancy also resulted in elevation of ANF concentration from 25 +/- 6 to 57 +/- 4 fmol/ml. With right atrial distension, the RAP-ANF relationships were similar in both nonpregnant and pregnant sheep, with a 10-mmHg increase in RAP increasing ANF by an average of 95 +/- 9 fmol/ml. In nonpregnant sheep, the LAP-ANF relationship was more responsive than RAP-ANF because a 10-mmHg increase in LAP resulted in a 193 +/- 10 fmol/ml increase in ANF. Moreover, during pregnancy, the LAP-ANF relationship was significantly more sensitive because a 10-mmHg increase in LAP resulted in a 433 +/- 15 fmol/ml elevation of ANF. These data demonstrate that plasma ANF levels are more responsive to distension of the left atria than to the right. More importantly, the ANF response to left, but not right, atrial distension is enhanced by pregnancy.

Effects of atriopeptin infusion versus effects of left atrial stretch in awake dogs

1986 ◽  
Vol 250 (2) ◽  
pp. R221-R226 ◽  
Author(s):  
K. L. Goetz ◽  
B. C. Wang ◽  
P. G. Geer ◽  
W. D. Sundet ◽  
P. Needleman
Keyword(s):  
Renal Function ◽  
Left Atrial ◽  
Free Water ◽  
Urine Flow ◽  
The Other ◽  
Potassium Excretion ◽  
Water Reabsorption ◽  
Hemodynamic Responses ◽  
Systemic Hemodynamic ◽  
Left Atrial Distension

We infused synthetic atriopeptin III intravenously into 10 conscious dogs while monitoring renal function and systemic hemodynamics. The results obtained from these infusion experiments were compared with results from other experiments in which left atrial distension was performed in the same dogs. Both atriopeptin infusion and left atrial distension caused significant increases in urine flow, sodium excretion, potassium excretion, and free water reabsorption and a significant decrease in renal blood flow. On the other hand, the pattern of systemic hemodynamic responses to atriopeptin infusion were quite different from the hemodynamic responses elicited by left atrial distension. However, there was a striking concordance between the renal effects of atriopeptin and those of left atrial distension. We therefore hypothesize that the renal response to left atrial distension in the conscious dog is mediated largely by the release of natriuretic peptides from the atria.

Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension

1993 ◽  
Vol 264 (2) ◽  
pp. R369-R375 ◽  
Author(s):  
K. Miki ◽  
Y. Hayashida ◽  
K. Shiraki
Keyword(s):  
Left Atrial ◽  
Steel Wire ◽  
Experimental Period ◽  
Conscious Dogs ◽  
Balloon Inflation ◽  
Renal Sympathetic Nerve Activity ◽  
Sustained Reduction ◽  
The Face ◽  
Left Atrial Distension

The role of cardiac-renal-neural reflex in the natriuresis induced by left atrial balloon inflation was investigated in conscious dogs. Female mongrel dogs were assigned randomly to 1) sham-operated (n = 8), 2) cardiac-denervated (n = 6), and 3) renal-denervated (n = 8) groups. The dogs were chronically instrumented with a bipolar stainless steel wire electrode for measurement of renal sympathetic nerve activity (RSNA). Balloon inflation induced a step increase in left atrial pressure (Pla) by 7.7 +/- 1.7 mmHg, a step decrease in RSNA (-66.6 +/- 5.5%), and concomitant increases in urine flow (441 +/- 142%), osmolal excretion (60 +/- 12%), and sodium excretion (300 +/- 69%) in sham-operated dogs. Renal denervation abolished the diuresis and natriuresis during balloon inflation. Chronic cardiac denervation abolished also the diuresis and natriuresis in the face of a similar increase in Pla. RSNA did not change significantly throughout the experimental period in cardiac-denervated dogs. It is concluded that a sustained reduction of RSNA originating from left atrial mechanoreceptors plays a major role in the natriuresis during left atrial distension in conscious dogs.

scholarly journals Evidence that urodilatin, rather than ANP, regulates renal sodium excretion.

1990 ◽  
Vol 1 (6) ◽  
pp. 867-874
Author(s):  
K Goetz ◽  
C Drummer ◽  
J L Zhu ◽  
R Leadley ◽  
F Fiedler ◽  
...  
Keyword(s):  
Sodium Excretion ◽  
Left Atrial ◽  
Cross Reactivity ◽  
Relative Importance ◽  
Experimental Conditions ◽  
Renal Sodium Excretion ◽  
Peptide Family ◽  
Radio Immunoassay ◽  
R Value ◽  
Left Atrial Distension

Urodilatin, a closely related member of the atrial peptide family, was discovered recently in human urine. Urodilatin (ANP 95-126) is believed to be produced within the kidney and is natriuretic; evidence indicates that most of the ANP-like immunoreactivity in the kidney elutes with urodilatin rather than with ANP. Moreover, urodilatin is little affected by renal enzymes that inactivate atriopeptin. To determine the relative importance of urodilatin versus ANP in the regulation of renal sodium excretion, we studied intact and cardiac-denervated conscious dogs under three experimental conditions: (1) spontaneous sodium excretion, (2) intravenous infusion of saline, and (3) left atrial distension. Urodilatin was measured in urine with a newly developed radioimmunoassay that selectively measures urodilatin without any cross-reactivity with alpha-human atrial natriuretic peptide (alpha-hANP); alpha-hANP was measured in plasma by radio-immunoassay because it is rapidly inactivated in the kidney by enzymatic activity. In each group of experiments, sodium excretion correlated better with urodilatin than it did with circulating alpha-hANP. The correlation coefficient (r value) between urodilatin excretion and renal sodium excretion exceeded 0.8 in 13 of 18 experiments and was below 0.6 in only 2 experiments. On the other hand, the correlation between circulating atriopeptin and sodium excretion exceeded 0.8 in only 3 of 18 experiments and was below 0.6 in 10 experiments. A negative correlation between plasma atriopeptin and renal sodium excretion was observed during left atrial distension in the cardiac-denervated dogs. These results and other considerations suggest that urodilatin, rather than atriopeptin, is the member of the ANP family that is primarily involved in the regulation of renal sodium excretion.

scholarly journals Mechanism of diuretic response to increased left atrial pressure in the anesthetized dog

1975 ◽  
Vol 8 (6) ◽  
pp. 355-361 ◽  
Author(s):  
Antoine de Torrente ◽  
Gary L. Robertson ◽  
Keith M. McDonald ◽  
Robert W. Schrier ◽  
Abby McCool ◽  
...  
Keyword(s):  
Left Atrial ◽  
Atrial Pressure ◽  
Left Atrial Pressure ◽  
Diuretic Response
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