scholarly journals Splanchnic nerve inhibition of gastric acid secretion and mucosal blood flow in anaesthetized cats

1971 ◽  
Vol 219 (3) ◽  
pp. 555-570 ◽  
Author(s):  
J. D. Reed ◽  
D. J. Sanders
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Mucosal Blood Flow ◽  
Splanchnic Nerve ◽  
Nerve Inhibition

Gastric Mucosal Blood Flow Response to Stimulation and Inhibition of Gastric Acid Secretion

1988 ◽  
Vol 95 (3) ◽  
pp. 642-650 ◽  
Author(s):  
Josep M. Pique ◽  
Felix W. Leung ◽  
Heck W. Tan ◽  
Edward Livingston ◽  
Oscar U. Scremin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Blood Flow Response ◽  
Flow Response

Capsaicin-sensitive afferent fibers contribute to gastric mucosal blood flow response to electrical vagal stimulation

1990 ◽  
Vol 259 (6) ◽  
pp. G1037-G1043 ◽  
Author(s):  
G. Thiefin ◽  
H. E. Raybould ◽  
F. W. Leung ◽  
Y. Tache ◽  
P. H. Guth
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Vagal Stimulation ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Vascular Response ◽  
Antidromic Activation ◽  
Afferent Fibers

Electrical stimulation of the peripheral vagus produces a noncholinergic increase in gastric mucosal blood flow (GMBF) via unknown mechanisms. The purpose of this study was 1) to investigate whether a portion of the increase in GMBF during prolonged electrical vagal stimulation involves a mechanism separate from augmented acid secretion and 2) to determine whether antidromic activation of afferent fibers contributes to the vascular or secretory responses to electrical vagal stimulation. Electrical vagal stimulation (40 V, 6 Hz, 2 ms) applied for 30 min to the distal cut end of the subdiaphragmatic ventral vagus significantly increased gastric acid secretion and GMBF measured by hydrogen gas clearance. Atropine (0.15 mg/kg iv) or omeprazole (10 mumol/kg iv) completely abolished the secretory response to electrical vagal stimulation, while a significant increase in GMBF remained. Pretreatment with perineural application of the sensory neurotoxin capsaicin to both cervical vagi significantly reduced by 48% the increase in GMBF but not gastric acid secretion; atropine completely abolished the remaining vascular response in capsaicin-treated rats. These results suggest that prolonged electrical vagal stimulation induces a sustained increase in GMBF partially independent of augmented acid secretion and that the noncholinergic portion of the vascular response is mediated by capsaicin-sensitive vagal afferent fibers.

Dissociated effects of somatostatin on gastric acid secretion and mucosal blood flow

1985 ◽  
Vol 248 (3) ◽  
pp. G337-G341
Author(s):  
F. W. Leung ◽  
P. H. Guth
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acid Output ◽  
Mucosal Blood Flow ◽  
Hydrogen Gas ◽  
Gastric Acid Output ◽  
Hydrogen Gas Clearance ◽  
Blood Flows

Somatostatin has been reported to control upper gastrointestinal hemorrhage, prevent restraint stress-induced gastric ulcerations, and inhibit gastric acid secretion. In this study we examined the effect of somatostatin on basal and pentagastrin-stimulated gastric acid output and mucosal blood flow. Antral and corpus mucosal blood flows were measured by hydrogen gas clearance in fasted, anesthetized rats. Acid output was determined by a continuous gastric perfusion technique. In the basal study somatostatin in doses of 8, 16, and 32 micrograms . kg-1 . h-1 was infused intravenously in separate groups of animals. In the pentagastrin stimulation study somatostatin (16 micrograms . kg-1 . h-1) was infused after gastric acid output was stimulated to plateau by intravenous pentagastrin (19.8 micrograms . kg-1 . h-1). The results showed that somatostatin had no effect on basal corpus or antral mucosal blood flow. During pentagastrin stimulation somatostatin decreased acid secretion but increased corpus mucosal blood flow. We speculate that this increase in blood flow may not be a direct effect as basal corpus or antral mucosal blood flow was unaffected by somatostatin.

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