scholarly journals Control of water content of non-metabolizing kidney slices by sodium chloride and polyethylene glycol (Peg 6000)

1971 ◽  
Vol 213 (1) ◽  
pp. 227-234 ◽  
Author(s):  
J. R. Robinson
Keyword(s):  
Polyethylene Glycol ◽  
Sodium Chloride ◽  
Water Content ◽  
Peg 6000 ◽  
Kidney Slices

Development, Evaluation and Optimization of Osmotic Controlled Tablets of Aceclofenac for Rheumatoid Arthritis Management

2019 ◽  
Vol 9 (1) ◽  
pp. 29-36
Author(s):  
Bijaya Ghosh ◽  
Niraj Mishra ◽  
Preeta Bose ◽  
Moumita D. Kirtania
Keyword(s):  
Rheumatoid Arthritis ◽  
Polyethylene Glycol ◽  
Sodium Chloride ◽  
Cellulose Acetate ◽  
Hydroxypropyl Methylcellulose ◽  
Release Profile ◽  
Polyethylene Glycol 400 ◽  
Permeable Membrane ◽  
Cumulative Release ◽  
The Core

Objective: Rheumatoid arthritis is a dreaded disease, characterized by pain, inflammation and stiffness of joints, leading to severe immobility problems. The disease shows circadian variation and usually gets aggravated in early morning hours. Aceclofenac, a BCS Class II compound is routinely used in the treatment of pain and inflammation associated with rheumatoid arthritis. The objective of this study was to develop an osmotic delivery system of Aceclofenac that after administration at bedtime would deliver the drug in the morning hours. </P><P> Methods: A series of osmotically controlled systems of aceclofenac was developed by using lactose, sodium chloride and hydroxypropyl methylcellulose K100M as osmogens. Cellulose acetate (2% w/v in acetone) with varying concentrations of polyethylene glycol-400 was used as the coating polymer to create semi permeable membrane and dissolution was carried out in 290 mOsm phosphate buffer. Formulation optimization was done from four considerations: cumulative release at the end of 6 hours (lag time), cumulative release at the end of 7 hours (burst time), steady state release rate and completeness of drug release. </P><P> Results: A formulation having swelling polymer hydroxypropyl methylcellulose in the core and lactose and sodium chloride as osmogens, polyethylene glycol-400 (16.39 %) as pore former, with a coating weight of 5% was a close fit to the target release profile and was chosen as the optimum formulation. Conclusion: Aceclofenac tablets containing lactose, HPMC and sodium chloride in the core, given a coating of cellulose acetate and PEG-400 (5% wt gain), generated a release profile for optimum management of rheumatoid arthritic pain.

scholarly journals Research on Electromagnetic Sensitivity Properties of Sodium Chloride during Microwave Heating

2020 ◽  
Vol 39 (1) ◽  
pp. 54-62
Author(s):  
Hua Chen ◽  
Junjiang Chen ◽  
Weijun Wang ◽  
Huan Lin
Keyword(s):  
Sodium Chloride ◽  
Electric Field ◽  
Water Content ◽  
Heating Rate ◽  
Microwave Heating ◽  
Resonant Cavity ◽  
Relative Dielectric Constant ◽  
Heating System ◽  
Heating Process ◽  
Heating Efficiency

AbstractThe multimode resonant cavity is the most common cavity. The material often shows on selective heating performance during the heating process due to the effect of microwave heating having a closely relationship with the electromagnetism parameters. This paper is based on finite difference time domain method (FDTD) to establish the electromagnetic-thermal model. The electromagnetic sensitivity property parameters of sodium chloride including relative dielectric constant, loss angle tangent and water content of sodium chloride is studied during the heating and drying process. The heating rate and the electric field distribution of sodium chloride, at the different water content, were simulated with the electromagnetic characteristic parameters changing. The results show that with the electromagnetic sensitivity property parameters varying, the electric field strength, heating rate and steady-state temperature of the heating material will all have a variety in the cavity. Some measures are proposed to improve the heating efficiency and ensure the stability of the microwave heating system in the industrial application.

scholarly journals Effect of Polyethylene Glycol (PEG) on Particle Distribution of Mn0.25Fe2.75O4-PEG 6000 Nanoparticles

2018 ◽  
Vol 1093 ◽  
pp. 012005
Author(s):  
Sunaryono ◽  
Kormil Saputra ◽  
Rosabiela Irfa Andina ◽  
Nurul Hidayat ◽  
Ahmad Taufiq ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Particle Distribution ◽  
Peg 6000

PATHOGENESIS OF SEIZURES OCCURRING DURING RESTORATION OF PLASMA TONICITY TO NORMAL IN ANIMALS PREVIOUSLY CHRONICALLY HYPERNATREMIC

PEDIATRICS ◽  
1969 ◽  
Vol 43 (1) ◽  
pp. 54-64
Author(s):  
Gwendolyn R. Hogan ◽  
Philip R. Dodge ◽  
Sheila R. Gill ◽  
Susan Master ◽  
Juan F. Sotos
Keyword(s):  
Sodium Chloride ◽  
Water Content ◽  
Nasogastric Tube ◽  
Chloride Solution ◽  
Sodium Chloride Solution ◽  
Sodium Level ◽  
Plasma Sodium ◽  
Plasma Sodium Level ◽  
The Mean ◽  
The Brain

The present study describes the results of rehydration of rabbits rendered chronically hypernatremic by the administration of one molar sodium chloride solution by nasogastric tube for 23½ to 5 days. When these animals were rehydrated intravenously over a 4-hour period with 2.5% dextrose in water, returning the plasma sodium level to normal, 55% of them developed focal or generalized convulsions. The mean water content of brain tissue of the group of animals who had seizures was significantly greater than that of a normal group of animals and comparable to that found in a water-intoxicated group of animals. This elevation of water content could be accounted for by both an elevated content of potassium and chloride in the brain. The potassium content of the brain was higher in the rehydrated group of animals without than those with seizures. Ways by which the observed changes may be related to the development of seizures are discussed.

scholarly journals Effect of Water Content on Sodium Chloride Sorption in Cross-Linked Cation Exchange Membranes

2019 ◽  
Vol 52 (6) ◽  
pp. 2569-2579
Author(s):  
Eui-Soung Jang ◽  
Jovan Kamcev ◽  
Kentaro Kobayashi ◽  
Ni Yan ◽  
Rahul Sujanani ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Cation Exchange ◽  
Water Content ◽  
Effect Of Water
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