scholarly journals Influence of the ionic environment on the membrane potential of adrenal chromaffin cells and on the depolarizing effect of acetycholine

1967 ◽  
Vol 191 (1) ◽  
pp. 107-121 ◽  
Author(s):  
W. W. Douglas ◽  
T. Kanno ◽  
S. R. Sampson
Keyword(s):  
Membrane Potential ◽  
Chromaffin Cells ◽  
Adrenal Chromaffin Cells ◽  
Ionic Environment ◽  
Adrenal Chromaffin

scholarly journals Probes of transmembrane potentials in platelets: changes in cyanine dye fluorescence in response to aggregation stimuli

Blood ◽  
1978 ◽  
Vol 51 (4) ◽  
pp. 741-749
Author(s):  
WC Horne ◽  
ER Simons
Keyword(s):  
Membrane Potential ◽  
Platelet Aggregation ◽  
Chromaffin Cells ◽  
Transmembrane Potential ◽  
Human Platelets ◽  
Cyanine Dye ◽  
Adrenal Chromaffin Cells ◽  
Stimulus Response ◽  
Transmembrane Potentials ◽  
Adrenal Chromaffin

A noncovalent fluorescent probe that responded to changes in transmembrane potential was used to study the response of washed human platelets to aggregating agents. Concentration-dependent changes in the fluorescence were observed in response to ADP and to thrombin. No such changes were observed in response to collagen fibrils. Thus there was an indication that platelet membrane potential changed in response to aggregating stimuli, supporting the hypothesis that the mechanisms of platelet aggregation resembled the mechanisms of other systems that show stimulus-response coupling (e.g., muscle, adrenal chromaffin cells). The different responses to specific agents indicate that the agents may trigger platelet aggregation through different mechanisms.

scholarly journals Probes of transmembrane potentials in platelets: changes in cyanine dye fluorescence in response to aggregation stimuli

Blood ◽  
1978 ◽  
Vol 51 (4) ◽  
pp. 741-749 ◽  
Author(s):  
WC Horne ◽  
ER Simons
Keyword(s):  
Membrane Potential ◽  
Platelet Aggregation ◽  
Chromaffin Cells ◽  
Transmembrane Potential ◽  
Human Platelets ◽  
Cyanine Dye ◽  
Adrenal Chromaffin Cells ◽  
Stimulus Response ◽  
Transmembrane Potentials ◽  
Adrenal Chromaffin

Abstract A noncovalent fluorescent probe that responded to changes in transmembrane potential was used to study the response of washed human platelets to aggregating agents. Concentration-dependent changes in the fluorescence were observed in response to ADP and to thrombin. No such changes were observed in response to collagen fibrils. Thus there was an indication that platelet membrane potential changed in response to aggregating stimuli, supporting the hypothesis that the mechanisms of platelet aggregation resembled the mechanisms of other systems that show stimulus-response coupling (e.g., muscle, adrenal chromaffin cells). The different responses to specific agents indicate that the agents may trigger platelet aggregation through different mechanisms.

scholarly journals Effects of GABA on membrane potential and intracellular Ca2+ concentration of bovine adrenal chromaffin cells.

1989 ◽  
Vol 49 ◽  
pp. 101
Author(s):  
Shigeo Kitayama ◽  
Hiroshi Ohtsuki ◽  
Katsuya Morita ◽  
Toshihiro Dohi ◽  
Akira Tsujimoto
Keyword(s):  
Membrane Potential ◽  
Chromaffin Cells ◽  
Adrenal Chromaffin Cells ◽  
Adrenal Chromaffin

Morphological Observations on the Granule Types in Rabbit Extra-Adrenal Chromaffin Cells.

1975 ◽  
Vol 33 ◽  
pp. 318-319
Author(s):  
Joe A. Mascorro ◽  
Robert D. Yates
Keyword(s):  
Chromaffin Cells ◽  
Sodium Phosphate ◽  
Ganglion Cells ◽  
Ultrastructural Level ◽  
Osmic Acid ◽  
Adrenal Chromaffin Cells ◽  
Potassium Iodate ◽  
Perfusion Fluid ◽  
New Zealand White Rabbits ◽  
Adrenal Chromaffin

Extra-adrenal chromaffin organs (abdominal paraganglia) constitute rich sources of catecholamines. It is believed that these bodies contain norepinephrine exclusively. However, the present workers recently observed epinephrine type granules in para- ganglion cells. This report investigates catecholamine containing granules in rabbit paraganglia at the ultrastructural level.New Zealand white rabbits (150-170 grams) were anesthetized with 50 mg/kg Nembutal (IP) and perfused with 3% glutaraldehyde buffered with 0.2M sodium phosphate, pH 7.3. The retroperitoneal tissue blocks were removed and placed in perfusion fluid for 4 hours. The abdominal paraganglia were dissected from the blocks, diced, washed in phosphate buffer and fixed in 1% osmic acid buffered with phosphate. In other animals, the glutaraldehyde perfused tissue blocks were immersed for 1 hour in 3% glutaraldehyde/2.5% potassium iodate buffered as before. The paraganglia were then diced, separated into two vials and washed in the buffer. A portion of this tissue received osmic acid fixation.

scholarly journals Stimulatory effect of serotonin on Na+-dependent Ca2+ efflux from bovine adrenal chromaffin cells in culture

1997 ◽  
Vol 73 ◽  
pp. 226
Author(s):  
Kazuo Minakuchi ◽  
Hitoshi Houchi ◽  
Masanori Yoshizumi ◽  
Yasuko Ishimura ◽  
Kyoji Morita ◽  
...  
Keyword(s):  
Chromaffin Cells ◽  
Adrenal Chromaffin Cells ◽  
Cells In Culture ◽  
Adrenal Chromaffin
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