scholarly journals The effect of adrenergic blocking agents on the guinea-pig uterusin vitro, and a study of the histology of the intrinsic myometrial nerves

1963 ◽  
Vol 169 (1) ◽  
pp. 73-90 ◽  
Author(s):  
P. Catherine Clegg
Keyword(s):  
Guinea Pig ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

Effect of adrenergic agents on responses of smooth muscle to angiotensin

1962 ◽  
Vol 202 (5) ◽  
pp. 841-844 ◽  
Author(s):  
Philip A. Khairallah ◽  
Irvine H. Page
Keyword(s):  
Smooth Muscle ◽  
Electrical Stimulation ◽  
Cell Membrane ◽  
Guinea Pig ◽  
Ganglion Cells ◽  
Adrenergic Nerves ◽  
Adrenergic Agents ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

Evidence has been presented previously indicating that angiotensin acts indirectly on guinea pig intestines by stimulating the ganglion cells of Auerbach's plexus. Further studies have shown that the adrenergic nerves are not directly involved in this mechanism, although adrenergic blocking agents suppress the response to angiotensin, probably by acting directly on the cell membrane. Epinephrine, and to a lesser extent norepinephrine and isoproterenol, inhibited the contraction of ileum and uterus to angiotensin, and to electrical stimulation, possibly by reversing or blocking sodium or potassium ion flux across the cell membrane resulting from the action of the peptide. Most of the adrenergic blocking agents studied, with the exception of Dibenamine, also inhibited the response to angiotensin. Reserpine, guanethidine, and bretylium block its action, possibly by releasing catecholamines from bound tissue stores, and phentolamine and piperoxane, by their sympathetic actions imitating the catecholamines.

Cardioselective .beta.-adrenergic blocking agents. 1. 1-[(3,4-Dimethoxyphenethyl)amino]-3-aryloxy-2-propanols

1975 ◽  
Vol 18 (2) ◽  
pp. 148-152 ◽  
Author(s):  
Milton L. Hoefle ◽  
Stephen G. Hastings ◽  
Robert F. Meyer ◽  
Ruth M. Corey ◽  
Ann Holmes ◽  
...  
Keyword(s):  
Beta Adrenergic ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Beta Adrenergic Blocking Agents ◽  
Adrenergic Blocking Agents
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